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TargetMol产品目录中 "

retina

"的结果
  • 抑制剂&激动剂
    45
    TargetMol | Inhibitors_Agonists
  • 化合物库
    1
    TargetMol | Compound_Libraries
  • 重组蛋白
    39
    TargetMol | Recombinant_Protein
  • 多肽产品
    4
    TargetMol | Peptide_Products
  • 天然产物
    10
    TargetMol | Natural_Products
  • 同位素
    1
    TargetMol | Isotope_Products
  • 检测抗体
    5
    TargetMol | Antibody_Products
  • DL-AP5
    DL-2-氨基-5-膦酰基缬草酸
    T2273376326-31-3
    DL-AP5 是选择性 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂的外消旋形式,具有抗惊厥作用。
    • ¥ 296
    In stock
    规格
    数量
  • All-trans-retinal
    视黄醛, Vitamin A aldehyde, Retinaldehyde, All trans-Retinal
    T5256116-31-4
    All-trans-retinal (Vitamin A aldehyde) 是视网膜中维生素A 代谢物之一。 生理条件下,它再生为视觉发色团,11-顺式-视黄醛。
    • ¥ 198
    In stock
    规格
    数量
  • 11-cis Retinal
    T38219564-87-4In house
    11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. When 11-cis retinal absorbs a photon of light, it isomerizes to form all-trans retinal beginning the phototransduction cycle, which is the basis for mammalian vision. A G121L mutation in opsin allows 11-cis retinal to bind as a partial agonist and activate rhodopsin in the absence of light. In a moth model of carotenoid deficiency-induced low visual sensitivity, 11-cis retinal application to compound eyes restored visual sensitivity almost completely.
    • ¥ 117550
    3-6月
    规格
    数量
  • 9-cis-Retinal
    9-顺式视黄醛
    T19169514-85-2
    9-cis-Retinal 是一种类视黄醇,对细胞视黄醇结合蛋白-I (CRBP-1) 和 CRBP-II 的 Kd 分别为 8 nM 和 5 nM。9-cis-Retinal 加快了视网膜类器官中杆感光细胞的分化和成熟,可降低无配体视蛋白的毒性,可用于研究由G90D视紫红质引起的先天性静止性夜盲症。
    • ¥ 1230
    In stock
    规格
    数量
  • 3-Diazirinophenylretinal
    T2939583374-72-5
    3-Diazirinophenylretinal is a bioactive chemical.
    • 待询
    规格
    数量
  • Retinaloxime
    trans-Retinaloxime
    T3429917672-05-8
    Retinaloxime is a retinoid.
    • ¥ 10600
    待询
    规格
    数量
  • Etretinate
    依曲替酯, Tegison, Ro 10-9359, Retinoid, Etretinato, Ethyl etrinoate
    T683154350-48-0
    Etretinate (Ro 10-9359) 是一种口服芳香族维甲酸,对牛皮癣和其他皮肤病综合征有效。 它激活类视黄醇受体,引起细胞分化的诱导、细胞增殖的抑制和炎症细胞对组织浸润的抑制。
    • ¥ 163
    In stock
    规格
    数量
  • NKP608
    NKP-608, NKP 608
    TQ0087177707-12-9In house
    NKP608 是一种具有选择性和高效性的神经激肽-1(NK-1)受体拮抗剂,具有抗癌抗焦虑活性,通过 Wnt 信号通路抑制人结直肠癌细胞的增殖。
    • ¥ 1170
    In stock
    规格
    数量
  • CYM5442
    T20261094042-01-9
    CYM5442 是高选择性和口服活性的鞘氨醇 1-磷酸受体激动剂,EC50为 1.35 nM。它激活依赖 S1P1的 p42 p44-MAPK 磷酸化,具有视网膜神经保护作用,可轻松穿过中枢神经系统。
    • ¥ 343
    In stock
    规格
    数量
  • Fenretinide
    芬维A胺, MK-4016, 4-hydroxy(phenyl)retinamide, 4-HPR
    T187265646-68-6
    Fenretinide (4-HPR) 是一种可口服的合成类维生素 A 衍生物,具有潜在的抗肿瘤和化学预防活性。
    • ¥ 229
    5日内发货
    规格
    数量
  • WS3
    T20551421227-52-2
    WS3 是一种可促进鼠和人原代胰岛的胰腺 β 细胞增殖的增殖分子。它可用于研究 I 型糖尿病。
    • ¥ 169
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Isoforretin A
    IsoA
    T898982231757-68-7
    Isoforretin A 作为一种高效的硫氧还蛋白-1 (Trx1) 抑制剂,具备显著的生物活性。它通过与Trx1活化位点的Cys32 Cys35残基共价结合,抑制Trx1功能并促进活性氧的积累,进而引发癌细胞的DNA损伤与凋亡(Apoptosis)。此外,Isoforretin A在小鼠肝细胞癌异种移植模型中,有效阻止了HepG2肿瘤细胞的增长。
    • 待询
    10-14周
    规格
    数量
  • Montbretin A
    TN8197115712-92-0
    Montbretin A, 一种存在于C. crocosmiiflora中的酰化黄酮醇糖苷,具备抗糖尿病的生物活性。
    • 待询
    规格
    数量
  • Docosahexaenoic Acid
    二十二碳六烯酸, DHA, Cervonic acid
    T53696217-54-5
    Docosahexaenoic Acid 属于天然产物,是一种 ω-3 脂肪酸,在脑和视网膜中较为丰富。Docosahexaenoic Acid 对大脑的生长和功能发育至关重要。
    • ¥ 198
    In stock
    规格
    数量
    TargetMol | Inhibitor Hot
  • 6-Chloromelatonin
    6-羟基褪黑素
    T2253063762-74-3In house
    6-Chloromelatonin 是一种有效的褪黑素受体 (melatonin receptor) 激动剂,是一种5-甲氧基吲哚化合物,可竞争兔视网膜中相同的突触前褪黑激素受体位点 ,可抑制[3H]多巴胺的钙依赖性释放 具有比褪黑素更高的代谢稳定性。6-Chloromelatonin 竞争 [3H] 褪黑素 与 MT2 受体结合 (pKi=9.77),可能用于研究与抑郁症相关的失眠和睡眠障碍。
    • ¥ 2350
    In stock
    规格
    数量
  • Retinol
    维生素A, 视黄醇, Vitamin A1, Alphalin, all-trans-Retinol
    T118368-26-8
    Retinol (Vitamin A) 属于天然维生素,具有脂溶性。Retinol 在视网膜的代谢功能、上皮组织的生长和分化、骨骼的生长、生殖和免疫反应中起重要作用。
    • ¥ 185
    In stock
    规格
    数量
  • Cidofovir dihydrate
    HPMPC, (S)-HPMPC, 西多福韦二水合物, GS 0504
    T8736149394-66-1
    Cidofovir dihydrate (HPMPC) 是注射型巨细胞病毒 DNA 聚合酶抑制剂,通过选择性抑制病毒 DNA 聚合酶来抑制 CMV 复制,从而阻止病毒复制和转录。
    • ¥ 142
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • DL-AP5 lithium
    DL-2-Amino-5-phosphonovaleric acid lithium, DL -2-氨基-5-磷戊酸锂盐, 2-APV lithium
    T201724125229-62-1
    DL-AP5 (2-APV) lithium, 作为一种竞争性的NMDA (N-methyl-D-aspartate)受体拮抗剂,具有显著的镇痛效果。此外,DL-AP5 lithium 还能特异性地阻断兔视网膜中的通道。
    • 待询
    10-14周
    规格
    数量
  • meso-Zeaxanthin
    T20457231272-50-1
    meso-Zeaxanthin 积聚在视网膜中央,与叶黄素和玉米黄质共同构成黄斑色素,具有滤光功能。meso-Zeaxanthin 能淬灭ROS,发挥抗氧化作用。
    • 待询
    10-14周
    规格
    数量
  • Timosaponin BII
    知母皂苷BII, Prototimosaponin A III
    T3394136656-07-0
    Timosaponin BII (Prototimosaponin A III) 是一种甾体皂苷,发现于知母根茎中,具有神经保护、抗炎和抗氧化作用。
    • ¥ 248
    In stock
    规格
    数量
  • (±)7(8)-EpDPA
    T35497895127-66-9
    Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenases. It is naturally occurring in plasma and brain and spinal cord tissues and is increased following dietary supplementation with ω-3 fatty acids. (±)7(8)-EpDPA and other epoxy metabolites of DHA modulate receptor and channel activities to evoke diverse effects, such as promoting vasodilation, inhibiting angiogenesis, and decreasing inflammatory and neuropathic pain. (±)7(8)-EpDPA is a substrate of soluble epoxide hydrolase (KM = 15 μM), which converts it to the corresponding diol.
    • 待估
    35日内发货
    规格
    数量
  • (±)10-HDHA
    T3550490780-50-0
    (±)10-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.[1][2] It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.[3][4][5] (±)10-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. Reference:[1]. VanRollins, M., and Murphy, R.C. Autooxidation of docosahexaenoic acid: Analysis of ten isomers of hydroxydocosahexaenoate. J. Lipid Res. 25(5), 507-517 (1984).[2]. Reynaud, D., Thickitt, C.P., and Pace-Asciak, C.R. Facile preparation and structural determination of monohydroxy derivatives of docosahexaenoic acid (HDoHE) by α-tocopherol-directed autoxidation. Anal. Biochem. 214(1), 165-170 (1993).[3]. VanRollins, M., Baker, R.C., Sprecher, H., et al. Oxidation of docosahexaenoic acid by rat liver microsomes. J. Biol. Chem. 259(9), 5776-5783 (1984).[4]. Yamane, M., Abe, A., and Yamane, S. High-performance liquid chromatography-thermospray mass spectrometry of epoxy polyunsaturated fatty acids and epoxyhydroxy polyunsaturated fatty acids from an incubation mixture of rat tissue homogenate. J. Chromatogr. 652(2), 123-136 (1994).[5]. Kim, H.Y., Karanian, J.W., Shingu, T., et al. Sterochemical analysis of hydroxylated docosahexaenoates produced by human platelets and rat brain homogenate. Prostaglandins 40(5), 473-490 (1990).
    • 待估
    35日内发货
    规格
    数量
  • (±)11-HDHA
    T3550587018-59-5
    (±)11-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelets and canine retina. In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets. 11(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 50, 4.7, and 7.5 μM, respectively. (±)11-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
    • 待估
    35日内发货
    规格
    数量
  • (±)13-HDHA
    T3550890780-53-3
    (±)13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra was shown to metabolize DHA to 13(R)-HDHA, presumably via the 11R-lipoxygenase activity. (±)13-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
    • 待估
    35日内发货
    规格
    数量