nap a

NAP-1 is a compound with anesthetic activity.1 It increases paired-pulse inhibition in the CA1 region of rat hippocampal brain slices when used at a concentration of 100 μM. NAP-1 also induces loss of righting reflex in tadpoles (EC50 = 0.53 μM).References NAP-1 is a compound with anesthetic activity.1 It increases paired-pulse inhibition in the CA1 region of rat hippocampal brain slices when used at a concentration of 100 μM. NAP-1 also induces loss of righting reflex in tadpoles (EC50 = 0.53 μM). References

25N-N1-Nap (compound 16) 作为一种偏向β-抑制蛋白的5-HT2A激动剂，能有效拮抗苯环利定在雄性C57BL 6j小鼠中引发的亢进现象。

Nap-FF 是一种具备细胞穿透性的二肽，用于研究水凝胶化学传感器的制备以及靶向药物递送。

N-Acetylprocainamide (NAPA) 是K+通道抑制剂，是第三代抗心律失常剂。

Acecainide hydrochloride (NAPA) 是 Procainamide 的肝脏主要代谢物，其抗心律失常作用可能导致肾衰竭时的心脏毒性。

NAP1051，一种仿生脂素 A4 类似物，专门针对炎症性肿瘤微环境，发挥抗肿瘤作用。该化合物能够有效抑制中性粒细胞对 fMLP 的趋化反应，并通过AKT激活促进巨噬细胞的胞葬作用 (efferocytosis)。NAP1051 主要应用于结直肠癌的相关研究。

Lonapalene (RS4317) 是一种 5-脂氧合酶 (5-LO) 抑制剂，具有抗银屑病的功效。Lonapalene 可局部阻断皮肤炎症。

Mebhydrolin napadisylate (Incidal) 是一种抗组胺药，用于缓解组胺释放引起的过敏症状，如鼻过敏和过敏性皮肤病。

Napabucasin (BBI608) 是一种口服的 Stat3 和 Y 干细胞活性抑制剂。

Birinapant (TL32711) 是一种二价 Smac 模拟物，是 XIAP 和 cIAP1的强效拮抗剂，Kd 值分别为 45 nM 和小于 1 nM。它靶向与 TRAF2 相关的 cIAP，并消除 TNF 诱导的 NF-κB 活化。

Tenapanor (RDX 5791) 是钠氢离子交换NHE3的有效抑制剂, 对人和大鼠NHE3的IC50分别是5和10 nM。

methyl (E)-sinapate 从 Polygala sibirica L.var. megalopha Fr 中分离得到。

Fanapanel hydrate is a highly selective antagonist of AMPA kainate with little activity against NMDA(Ki of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively).

Fanapanel（ZK200775,法那帕奈）是一种喹草胺二酮衍生物和高效的AMPAR的竞争性拮抗剂，可用于脑血管相关研究。

ASTX660是一种新型非肽模拟拮抗剂，针对cIAP1 2和XIAP，能有效诱导癌细胞系中TNFα-依赖的凋亡，并抑制肿瘤生长。

Phencarbamide napadisilate 是一种在分娩期间使用的抗痉挛和抗胆碱能化合物。

Abediterol napadisylate is a novel long-acting β2-agonist in persistent asthma that is efficacy, safe, and tolerable.

Aclatonium Napadisilate, a cholinergic agonist, has been shown to stimulates endocrine and exocrine pancreatic secretion.

Napamezole is an α2 adrenergic receptor antagonist. Napamezole antagonizes methoxamine-induced contractions (alpha-1) of the rat vas deferens with a Kb of 135 nM. Napamezole reverses clonidine-induced decreased in twitch height in the electrically stimula

L-Napamp is a bioactive chemical.

Xevinapant hydrochloride (AT-406 HCl) 是口服生物可利用的 Smac 模拟物，也是细胞凋亡蛋白抑制剂的拮抗剂。它在无细胞功能测定中有效拮抗 XIAP BIR3 蛋白，诱导细胞 cIAP1 蛋白的快速降解，并抑制各种人类癌细胞系中的癌细胞生长。它在诱导异种移植肿瘤细胞凋亡方面非常有效。

Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 µM) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 µM), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 µM, respectively). [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2 M phase. Darinaparsin decreases transcription of Gli-2, a transcription factor that mediates Sonic hedgehog signaling, when used at a concentration of 1.5 but not 3 µM. It decreases SHP1 phosphatase activity and increases ERK phosphorylation. [2] Darinaparsin reduces tumor growth in DU145 and PC3 prostate cancer mouse xenograft models when administered at a dose of 100 mg kg every other day.[1]

9-cis-Vitamin A palmitate (9-cis-Retinyl palmitate) is a 9-cis isomer resulting from the interaction of vitamin A palmitate in corn flakes. It exhibits a biological activity of 26% compared to all-trans-vitamin A palmitate, which is known to be the most biologically active form of vitamin A.

Lesogaberan (AZD-3355) napadisylate is a potent and selective agonist of GABA B receptors, with an EC 50 of 8.6 nM for human recombinant GABA B receptors. It demonstrates an affinity (Ki) of 5.1 nM for rat GABA B receptors and 1.4 μM for GABA A receptors, as determined by its displacement of [3H]GABA binding in brain membranes. Notably, Lesogaberan napadisylate exerts a peripheral mode of action, inhibiting transient lower esophageal sphincter relaxation.