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Anti-CXCL1 Antibody (2U261)
还可以产品编号 TMAY-01273
Anti-CXCL1 Antibody (2U261) 是一种 Mouse 抗体，靶向 CXCL1。Anti-CXCL1 Antibody (2U261) 可用于 ELISA(Det)。
Anti-CXCL1 Antibody (2U261)
Anti-CXCL1 Antibody (2U261)
还可以产品编号 TMAY-01273
Anti-CXCL1 Antibody (2U261) 是一种 Mouse 抗体，靶向 CXCL1。Anti-CXCL1 Antibody (2U261) 可用于 ELISA(Det)。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-CXCL1 Antibody (2U261) is a Mouse antibody targeting CXCL1. Anti-CXCL1 Antibody (2U261) can be used in ELISA(Det). |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 2U261 |
| 交叉反应 | Human |
| 应用 | ELISA(Det) |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CXCL1 (rh CXCL1; TMPY-02868; P09341-1; Ala35-Asn107). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions through CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CXCL1 Protein (TMPY-02868) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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