lc 6

LC 6 is an orally active antiallergic agent.

SPOP-IN-6lc 是一种有效的 SPOP 抑制剂，在癌症中有多种作用，在多种肿瘤中有抑癌作用，在肾癌中却发挥着癌基因功能。SPOP-IN-6lc 可用于研究细胞信号传送和细胞凋亡。

Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) 是一种有效的基于聚乙二醇的 PROTAC 连接剂，常被用于 PROTAC 合成氯烷(HaloPROTACs)。

Diclofensine (Ro 8-4650) 是一种单胺再摄取抑制剂，在大鼠脑突触体中能够阻断多巴胺 (IC50=0.74 nM)、去甲肾上腺素 (IC50=2.3 nM) 和 5-羟色胺 (IC50=3.7 nM)。

Fluoxetine (LY-110140) 是一种高度特异性的血清素摄取抑制剂，是选择性 5-羟色胺 (5-HT) 再吸收抑制剂。Fluoxetine 具有抗抑郁活性。

Amitriptyline hydrochloride (Annoyltin) 是血清素再摄取转运体和去甲肾上腺素再摄取转运体抑制剂，还与多巴胺再摄取转运体结合，其Ki 为 2.58 μM。它也抑制肾上腺素能受体、毒蕈碱受体、组胺受体、5-羟色胺受体。它是TrkA 和TrkA 受体的激动剂，具有强神经营养活性和有抗抑郁作用。

Escitalopram (Seroplex) 是一种外消旋 Citalopram 的 S-对映体，是一种选择性 5-羟色胺再摄取抑制剂，Ki=0.89 nM，比 R(-)-enantiomer 结合亲和力高 30 倍。它对多巴胺转运体和去甲肾上腺素转运体均有选择性，是一种研究抑郁症的抗抑郁药。

DOV-216,303 Free Base (DOV-216303) 是血清素、去甲肾上腺素和多巴胺再摄取的抑制剂，IC50 为 14、20 和 78 nM。 DOV-216,303 Free Base 具有抗抑郁作用。

Mal-C6-amine (TFA) is an alkyl chain-based linker employed in the synthesis of PROTACs[1].

Cl-C6-PEG4-C3-COOH, a PROTAC linker, is a suitable component for synthesizing chloroalkane-containing PROTACs (HaloPROTACs).

Mal-C6-α-Amanitin is a drug-linker conjugate for ADC with potent antitumor activity by using α-Amanitin (an RNA polymerase II inhibitor), linked via the ADC linker Mal-C6.

VH032-thiol-C6-NH2, also known as VHL Ligand-Linker Conjugates 14, is a synthesized compound that functions as an E3 ligase ligand-linker conjugate. This compound combines the VH032 based VHL ligand with a linker commonly utilized in PROTAC technology.

SLC6A8 corrector 1 为一种能够穿透血脑屏障的口服活性突变型SLC6A8变体校正剂。该化合物主要用于研究肌酸转运蛋白缺乏症（CTD）。

ALC67 has a promising anticancer activity that results in the recent discovery of a series of 3-propionyl thiazolidine-4-carboxylic acid ethyl esters as a family of novel antiproliferative agents. It is an activator of the caspase-9 involved apoptotic pat

Functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 phenol - linker 2 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC6 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Duloxetine 是一种 5 羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂，Ki=4.6 nM，可作用于广泛性焦虑症的研究。

Azaphen (Pipofezin hydrochloride) 是一种 5-羟色胺重吸收抑制剂。

Thalidomide 5'-amine-alkylC6-amine是用于PROTAC研究与开发的功能化cereblon配体；包含一个E3连接酶配体和一个带有末端胺基的alkylC6连接器，用于与目标蛋白配体的结合。这是一系列用于PROTAC研发的功能化工具分子之一。

Pomalidomide 4'-alkylC6-azide，一种Pomalidomide基础上的E3泛素连接酶cereblon(CRBN)配体，其作用为募集cereblon蛋白。通过linker连接至蛋白质配体，Pomalidomide 4'-alkylC6-azide能够形成PROTAC。

AChE-IN-73 (compound 6)，作为一种高效的杀虫剂，对C. pipiens的半致死浓度（LC50）为78.0 mg L。该化合物对乙酰胆碱酯酶（AChE）和烟碱乙酰胆碱受体（nAChR）显示出高亲和力，其结合能力分别达到-8.11 kcal mol 和 -6.27 kcal mol，表明AChE-IN-73是一个潜在的有效抗蚊化合物。

Sulfo-NHS-LC-Biotin, or Sulfosuccinimidyl 6-(biotinamido) Hexanoate, is a long-chain water-soluble biotinylating agent that targets cell surface proteins and is reactive to primary amine groups.

β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils. β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes. It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 μg/ml, respectively. β-Defensin-4 induces IL-31 production by human peripheral blood-derived mast cells in vitro when used at a concentration of 10 μg/ml and by rat mast cells in vivo following a 500 ng intradermal dose. It also inhibits growth of E. coli, P. aeruginosa, and S. aureus with lethal concentration (LC) values of 5, 12, and 15 μM, respectively, of S. carnosus (MIC = 4.5 μg/ml), and of C. albicans with a minimum fungicidal concentration (MFC) value of 7.5 μM.

13C15-Nivalenol is intended for use as an internal standard for the quantification of nivalenol by GC- or LC-MS. Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It is lethal to mice (LD50= 6.9 mg kg).2Nivalenol (5, 10, and 15 mg kg) also induces thymic, splenic, and Peyer's patch cell apoptosis in mice.3 1.Yang, Z., Concannon, J., Ng, K.S., et al.Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulationSci. Rep.630263(2016) 2.Yoshizawa, T., and Morooka, N.Studies on the toxic substances in the infected cereals (part 3): Acute toxicities of new trichothecene mycotoxins: Deoxynivalenol and its monoacetateJ. Food Hyg.15(4)261-269(1974) 3.Poapolathep, A., Ohtsuka, R., Kiatipattanasakul, W., et al.Nivalenol-induced apoptosis in thymus, spleen and Peyer's patches of miceExp. Toxicol. Pathol.53(6)441-446(2002)