hdm2

Serdemetan (JNJ-26854165) 是一种 HDM2泛素连接酶拮抗剂，能诱导 p53野生型细胞的早期凋亡。

p53-HDM2-IN-1 是一种有效的 p53-HDM2蛋白-蛋白相互作用抑制剂，IC50值为 0.103 μM。p53-HDM2-IN-1 可用于癌症研究。

HDM-201 succinate is an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity.

Siremadlin (NVP-HDM 201) 是一种有效的、可口服的、高度特异性的 p53-MDM2 相互作用抑制剂。

OD38 is a novel potent and selective receptor-interacting protein kinase 2 (ripk2) inhibitor

EAPB-0503，一种imidazoquinoxaline类及Imiquimod类似物，针对表达NPM1c的细胞选择性降低HDM2表达并激活p53途径，从而引发细胞凋亡。

HLI373 是一种有效的 Hdm2抑制剂, Hdm2 是一种泛素连接酶(E3)。HLI373 可有效诱导肿瘤细胞 (对 DNA 破坏剂敏感的) 凋亡 (apoptosis)，并且具有抗疟疾 (antimalarial) 活性。

TDP665759 is an inhibitor of the Hdm2:p53 complex that acts by suppressing human tumor cell proliferation in vitro.

HLI98C is a HDM2 ubiquitin ligase inhibitor with anti-tumor activity.

HLI98D is a HDM2 ubiquitin ligase inhibitor with anti-tumor activity.

HLI98E is a HDM2 ubiquitin ligase inhibitor with anti-tumor activity.

HLI373 dihydrochloride is a potent Hdm2 inhibitor, efficiently restraining the ubiquitin ligase activity of Hdm2 and effectively prompting apoptosis in DNA-damaging agent-sensitive tumor cells[1]. Additionally, HLI373 dihydrochloride exhibits antimalarial activity[2].

SCH529074 是 p53 的选择性激活剂 (Ki = 1 μM)，可用于非小细胞肺癌的研究。 SCH529074 恢复突变 p53 功能并中断 HDM2 介导的野生型 p53 泛素化。

MK-4688 is an efficient inhibitor of the HDM2-p53 protein-protein interaction.

MI-219 is a human double minute 2 (HDM2) inhibitor.

XL-188 is a highly potent and selective inhibitor of USP7. XL188 inhibited USP7 catalytic domain and full-length enzyme with IC50 values of 193 and 90 nM, respectively. XL188 Promotes USP7-Dependent Loss of HDM2 and Increase of p53 and p21. XL188 represents one of only a small set of mammalian DUB inhibitors with low nanomolar potency and a high degree of selectivity relative to other DUBs

NVP-CFC218 is a novel potent and selective p53-HDM2 inhibitor.