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抑制剂&激动剂
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  • 抑制剂&激动剂
    15
    TargetMol | Inhibitors_Agonists
  • 化合物库
    2
    TargetMol | Compound_Libraries
  • 重组蛋白
    6
    TargetMol | Recombinant_Protein
  • 天然产物
    5
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    TargetMol | Isotope_Products
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    TargetMol | Antibody_Products
  • Maslinic acid
    山楂酸, Crategolic acid, 2α-Hydroxyoleanolic acid, 2α-Hydroxyoleanoic Acid
    T37724373-41-5
    Maslinic acid (Crategolic acid) 是一种 DNA 聚合酶 B 抑制剂,抑制 NF-κB p65的 DNA 结合活性并消除 IκB-α磷酸化。
    • ¥ 229
    In stock
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  • GS-9191
    GS 9191
    T25466859209-84-0In house
    GS-9191是一种DNA 聚合酶α和ß 的强效抑制剂 ,是一种新型核苷类似物9-(2-膦酰甲氧基乙基)鸟嘌呤(PMEG)的原药 ,可渗透皮肤并在上皮层代谢为活性核苷三磷酸类似物。GS-9191具有抗增殖活性,以剂量相关的方式减少乳头瘤的大小。GS-9191可能对治疗HPV 引起的病变有作用。
    • ¥ 756
    In stock
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    TargetMol | Inhibitor Sale
  • Dacarbazine
    达卡巴嗪, Imidazole Carboxamide, DTIC-Dome
    T11204342-03-4
    Dacarbazine (DTIC-Dome) 是一种抗肿瘤剂,对黑色素瘤具有显着的活性。
    • ¥ 232
    In stock
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  • Vidarabine
    阿糖腺苷, Vira-A, Arabinosyladenine, Ara-A, Adenine Arabinoside, 9-β-D-Arabinofuranosyladenine
    T15065536-17-4
    Vidarabine (Adenine Arabinoside) 是从链霉菌分离的核苷类抗生素,能抗单纯性疱疹和水痘-带状疱疹病毒。它对 HSV-1 和 HSV-2 的 IC50值分别为 9.3 μg ml 和 11.3 μg ml。
    • ¥ 298
    In stock
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  • Fidaxomicin
    非达米星, Tiacumicin B, PAR-101, OPT-80, Clostomicin B1
    T6194873857-62-6
    Fidaxomicin (Tiacumicin B) 是一种大环RNA 聚合酶抑制剂,具有窄谱活性。它选择性地根除致病性艰难梭菌,对构成正常健康肠道菌群的多种细菌影响很小。
    • ¥ 163
    In stock
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  • Famciclovir
    泛昔洛韦, BRL 42810
    T1646104227-87-4
    Famciclovir (BRL 42810) 是一种单纯疱疹病毒核苷类似物 DNA 聚合酶抑制剂。
    • ¥ 289
    In stock
    规格
    数量
  • LB80317
    LB-80317, LB 80317, ANA-317, ANA317, ANA 317
    T27801441785-24-6
    LB-80317, a DNA polymerase inhibitor, is used potentially for the potential treatment of hepatitis B virus infection.
    • 待询
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  • Cynaroside
    木犀草苷, 朝蓟糖甙, Luteoloside, Luteolin 7-β-D-Glucopyranoside, Luteolin 7-O-β-D-glucoside, Luteolin 7-O-Glucoside, Luteolin 7-glucoside
    T33765373-11-5
    Cynaroside (Luteolin 7-O-Glucoside) 是一个抗氧化类黄酮。它还是一种流感依赖 RNA 的RNA 聚合酶抑制剂,IC50为 32 nM。
    • ¥ 311
    In stock
    规格
    数量
  • Thiocoraline
    T36096173046-02-1
    Thiocoraline is a depsipeptide and DNAbis-intercalator originally isolated fromMicromonosporawith antibacterial and anticancer activities.1,2It is active against the Gram-positive bacteriaS. aureus,B. subtilis, andM. luteus(MICs = 0.05, 0.05, and 0.03 μg ml, respectively) but not Gram-negativeE. coli,K. pneumoniae, orP. aeruginosa(MICs = >100 μg ml for all).1Thiocoraline inhibits RNA and DNA polymerase and thymidylate synthase (IC50s = 6, 6, and 15 μg ml, respectively), as well as RNA and DNA synthesisin vitro(IC50s = 0.008 and 0.4 μg ml, respectively). It is cytotoxic to P388, A549, HT-29, and MEL-28 cancer cells (IC50s = 0.002, 0.002, 0.01, and 0.002 μg ml, respectively). 1.Romero, F., Espilego, F., Pérez Baz, J., et al.Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activitiesJ. Antibiot. (Tokyo)50(9)734-737(1997) 2.Negri, A., Marco, E., García-Hernández, V., et al.Antitumor activity, X-ray crystal structure, and DNA binding properties of thiocoraline A, a natural bisintercalating thiodepsipeptideJ. Med. Chem.50(14)3322-3333(2007)
    • ¥ 2900
    35日内发货
    规格
    数量
  • AZT triphosphate TEA
    T36490
    AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3]. Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts[1]. [1]. Ryosuke Nomura, et al. Azidothymidine-triphosphate Impairs Mitochondrial Dynamics by Disrupting the Quality Control System. Redox Biol. 2017 Oct;13:407-417. [2]. Takeya Sato, et al. Engineered Human tmpk/AZT as a Novel Enzyme/Prodrug Axis for Suicide Gene Therapy. Mol Ther. 2007 May;15(5):962-70. [3]. K Y Hostetler, et al. Enhanced Oral Absorption and Antiviral Activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and Related Compounds in Hepatitis B Virus Infection, in Vitro. Biochem Pharmacol. 1997 Jun 15;53(12):1815-22.
    • ¥ 5232
    待询
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  • Tenofovir diphosphate (sodium salt)
    T37523
    Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase (Kis = 0.022 and 1.55 μM for RNA and DNA, respectively) and hepatitis B virus (HBV) polymerase (Ki = 0.18 μM). It is selective for these enzymes over DNA polymerase α and β, as well as mitochondrial DNA polymerase γ (Kis = 5.2, 81.7, and 59.5 μM, respectively). Tenofovir diphosphate is formed intracellularly through phosphorylation of the prodrugs tenofovir and tenofovir disoproxil by nucleotide kinases. Increased levels of tenofovir diphosphate in isolated peripheral blood mononuclear cells (PBMCs) correlate with a decrease in the risk of simian HIV (SHIV) acquisition in a macaque model of rectal SHIV transmission.
    • 待估
    35日内发货
    规格
    数量
  • Ribavirin-13C5
    Ribavirin-13C5
    T382971646818-35-0
    Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50= 109.5 μM).4Aerosol administration of ribavirin (30 mg/kg) reduces mortality in a mouse model of influenza A infection.5Formulations containing ribavirin have been used in the treatment of respiratory syncytial virus (RSV), hepatitis C virus (HCV), and viral hemorrhagic fevers. 1.Gilbert, B.E., and Knight, V.Biochemistry and clinical applications of ribavirinAntimicrob. Agents Chemother.30(2)201-205(1986) 2.Gordon, C.J., Tchesnokov, E.P., Woolner, E., et al.Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potencyJ. Biol. Chem.295(20)6785-6797(2020) 3.Kirsi, J.J., North, J.A., McKernan, P.A., et al.Broad-spectrum antiviral activity of 2-β-D-ribofuranosylselenazole-4-carboxamide, a new antiviral agentAntimicrob. Agents Chemother.24(3)353-361(1983) 4.Wang, M., Cao, R., Zhang, L., et al.Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitroCell Res.30(3)269-271(2020) 5.Wilson, S.Z., Knight, V., Wyde, P.R., et al.Amantadine and ribavirin aerosol treatment of influenza A and B infection in miceAntimicrob. Agents Chemother.17(4)642-648(1980)
    • ¥ 7880
    35日内发货
    规格
    数量
  • Clevudine
    克拉夫定, L-FMAU, Levovir
    T6446163252-36-6
    Clevudine (Levovir) 是一种非自然 L-构型的核苷类似物,是一种与聚合酶结合的非竞争性抑制剂,具有较强的抗 HBV 活性,半衰期长,毒性低的特点。
    • ¥ 118
    In stock
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  • Fialuridine
    非阿尿苷, FIAU, DRG-0098
    T765569123-98-4
    Fialuridine (DRG-0098) 是一种 DNA 导向的 DNA 聚合酶抑制剂,可能用于治疗 HBV 感染,在体外和体内对乙型肝炎病毒具有有效的活性。
    • ¥ 247
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • 3-O-trans-p-Coumaroylmaslinic acid
    3-O-反式对香豆酰基山楂酸
    TN614835482-91-8
    3-beta-O-(trans-p-Coumaroyl)maslinic acid is a DNA polymerase B inhibitor. It shows antimicrobial activity on Gram-positive bacteria and yeasts.
    • ¥ 13800
    5日内发货
    规格
    数量
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