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抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
T60426 HIV-IN-4

HIV-IN-4 (Compound 12) 是有效的HIV 抑制剂,具有良好的抗 HIV 病毒活性。
T74488 HIV-1 protease-IN-4

HIV-1protease-IN-4 (Compound II-22) 是一种有效的HIV-1蛋白酶抑制剂。HIV-1protease-IN-4 是阿扎那韦的前体。HIV-1蛋白酶-IN-4 作为前体,与口服母体活性分子相比,将母体 1 输送到大鼠血浆中的 AUC 高 5 倍,C24 高 67 倍[1]。
TQ0174 Mavorixafor

AMD-070

CXCR Autophagy; GPCR/G Protein; Immunology/Inflammation
Mavorixafor (AMD-070) 是一种有效的特异性 CXCR4 拮抗剂,对 CXCR4 125I-SDF 结合的 IC50 值为 13 nM。 Mavorixafor 在 MT-4 细胞 (IC50 = 1 nM) 和 PBMC (IC50 = 9 nM) 中抑制 T-tropic HIV-1 (NL4.3 株) 的复制。
T67833 HIV-1 inhibitor-54

HIV Protease Microbiology/Virology; Proteases/Proteasome
HIV-1 inhibitor-54 是一种有效的 HIV-1 抑制剂,在 MT-4 细胞中对 WT HIV-1 (菌株 IIIB) x 显示出抗 HIV 活性(EC50 : 32 nM)。HIV-1 inhibitor-54 可用于研究病毒感染。
T11465 Lenacapavir

GS-6207

Others; HIV Protease Microbiology/Virology; Others; Proteases/Proteasome
Lenacapavir (GS-6207) 是一种有效的靶向衣壳的 HIV 复制抑制剂。 Lenacapavir 在 MT-4 细胞中显示出抗 HIV 活性,EC50 为 100 pM。
T0028 Gamibetal

3-Hydroxy-GABA,4-氨基-3-羟基丁酸,4-Amino-3-hydroxybutyric Acid

HIV Protease Microbiology/Virology; Proteases/Proteasome
Gamibetal (4-Amino-3-hydroxybutyric Acid) 是 γ-氨基-β-羟基丁酸,对癫痫具有潜在的研究价值。
T14313 Apricitabine

AVX754,SPD754

HIV Protease; DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
Apricitabine (SPD754) 是一种具有高选择性和口服活性的HIV-1逆转录酶抑制剂(Ki=0.08μM),是2′-脱氧-3′-氧-4′-硫代胞苷(dOTC)的(-)对映体 。 Apricitabine 对DNA 聚合酶α、β和γ具有抑制作用,Ki 值分别为300μM、12μM 和112.25μM。Apricitabine 在抗逆转录病毒HIV 感染者中显示出良好的抗逆转录病毒治疗效果,具有良好的耐受性和较低的选择性抗性。
T3360 ZK 756326

ZK756326 2HCl

CCR Immunology/Inflammation; Microbiology/Virology
ZK 756326 是一种选择性的非肽 CCR8 趋化因子受体激动剂(IC50:1.8 μM,在人体内;2.6 μM,在小鼠体内)。对 CCR4/5 和 CXCR3/4 没有活性,比其他 26 种 GPCR 的选择性高 28 倍(对 α2A 和 5-HT 受体的选择性较低)。诱导趋化性并抑制 Env 介导的 (HIV) 细胞-细胞融合。
T7208 AMD 3465 hexahydrobromide

GENZ-644494 (hexahydrobromide)

HIV Protease; CXCR Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) 是一种 CXCR4受体拮抗剂,具有潜在的抗癌和抗 HIV 活性。
T11693L IT1t dihydrochloride

CXCR Autophagy; GPCR/G Protein; Immunology/Inflammation
IT1t dihydrochloride 抑制 CXCL12/CXCR4 相互作用,IC50 为 2.1 nM。 IT1t dihydrochloride 是 CXCR4 的拮抗剂。
T10296 Mavorixafor trihydrochloride

AMD-070 trihydrochloride

HIV Protease Microbiology/Virology; Proteases/Proteasome
Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (IC50s: 1 and 9 nM).
T10141 4'-Ethynyl-2'-deoxyadenosine

Others Others
4'-Ethynyl-2'-deoxyadenosine (4'-E-dA) is a nucleoside reverse transcriptase (RT) inhibitor. It is potent against drug-resistant HIV variants (EC50: 98 nM in MT-4 cells for anti-HIV-1 activity).
T15776 Loviride

R 89439

Others Others
Loviride is a non-nucleoside reverse transcriptase inhibitor (IC50: 0.3 µM). Loviride inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells. It is used for reverse transcriptase from HIV-1.
T62070 HIV-1 inhibitor-31

HIV-1 inhibitor-31 (compound 4) 是一种 HIV-1 的有效抑制剂。HIV-1 inhibitor-31 能够用于研究艾滋病。
T29393 3'-Deoxy-4-thiothymidine

Thymidine, 3'-deoxy-4-thio-,Ddthds

3'-Deoxy-4-thiothymidine can moderately active in protecting HIV-induced cytopathogenicity of MT-2 and CEM cells.
T15045 D77

Others Others
D77 is anti-HIV-1 inhibitor. D77 inhibits HIV-1(IIIB) replication by EC50 value of 23.8 μg/ml in MT-4 cell (5.03 μg/ml for C8166 cells).
T62353 HIV-1 inhibitor-33

HIV-1 inhibitor-33 (compound 5n) 是一种有效的、选择性的 HIV-1 抑制剂,作用于 HIV-1 (EC50: 8.6 nM)、MT-4 细胞 (CC50: 18 μM)。HIV-1 inhibitor-33 能够用于研究艾滋病。
T62782 HIV-1 inhibitor-34

HIV-1 inhibitor-34 (compound 5q) 是一种有效的、选择性的 HIV-1 抑制剂,作用于 HIV-1 (EC50: 6.4 nM)、MT-4 细胞 (CC50: 16 μM)。HIV-1 inhibitor-34 能够用于研究艾滋病。
T72206 Reverse transcriptase-IN-4

Reverse transcriptase-IN-4 是一种有效的选择性非核苷类逆转录酶 (NNRT) 抑制剂,作用于野生型HIV-1的EC50值为 0.053 μM,作用于HIV-1突变株 E138K 的EC50值为 0.26 μM。
T63499 HIV-1 inhibitor-28

HIV-1 inhibitor-28 是高效的、选择性的HIV-1抑制剂,对野生型 HIV-1 的EC50=58 nM,对野生型 HIV-1 逆转录的IC50=3.37 μM,对 MT-4 细胞有相对较低的毒性,其CC50= 38.6 μM。HIV-1 inhibitor-28 能够用于研究艾滋病。
T61797 HIV-1 inhibitor-15

HIV-1 inhibitor-15 (compound 9d) is a potent and broad-spectrum inhibitor targeting HIV-1. It exhibits inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, and E138K with respective EC50 values of 1.7 nM, 4 nM, 2 nM, 6 nM, and 9 nM. In addition to its high efficacy, HIV-1 inhibitor-15 possesses favorable solubility, safety profiles, and oral bioavailability [1].
T71009 Dolutegravir SR Isomer

Dolutegravir SR Isomer is an isomeric derivative of Dolutegravir -- a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
T70881 Dolutegravir RR Isomer

Dolutegravir RR Isomer is an isomer of Dolutegravir -- a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
T63962 HIV-1 inhibitor-29

HIV-1 inhibitor-29 是 HIV-1 的有效抑制剂,能够作用于 HIV-1 IIIB (EC50: 2.18 μM)。HIV-1 inhibitor-29 对 F227L/V106A 株表现出较高的抗耐药性,其 EC50 值为 0.974 μM。HIV-1 inhibitor-29 对 MT-4 细胞显示出较低的细胞毒性,其 CC50 值为 211 μM。HIV-1 inhibitor-29 能够用于研究艾滋病。
T69081 KRH-1636

KRH-1636 is an orally active, selective and extremely potent CXC chemokine receptor 4 antagonist. KRH-1636 exhibits a potent and selective anti-HIV-1 activity. KRH-1636 efficiently blocked replication of various T cell line-tropic (X4) HIV type 1 (HIV-1) in MT-4 cells and peripheral blood mononuclear cells through the inhibition of viral entry and membrane fusion via the CXC chemokine receptor (CXCR)4 coreceptor but not via CC chemokine receptor 5. KRH-1636 also inhibits binding of the CXC chem...
T62430 HIV-1 inhibitor-24

HIV-1 inhibitor-24 (compound S-12a) 是一种 HIV-1 逆转录 (HIV-1 RT) 的高效抑制剂 (IC50: 9.5 nM)。HIV-1 inhibitor-24 对野生型 HIV-1 表现出较高的抗病毒效果,其 EC50 值为 1.6 nM,且细胞毒性较低 (对 MT-4 细胞的 CC50 值为 9.07 μM)。HIV-1 inhibitor-24 在小鼠中 2 g/kg 剂量下具有良好的耐受性,并具有明显的心血管安全性。
T78925 HIV-1 inhibitor-58

HIV-1inhibitor-58(Compound 10c)是一款抗逆转录病毒活性的广谱非核苷逆转录酶抑制剂,有效抑制MT-4细胞中的HIV-1 WT株IIIB以及NNRTI耐药菌株,如K103N和E138K(EC50 < 50 nM)。此外,HIV-1inhibitor-58对CYP2C9与CYP2C19也表现出抑制作用(IC50分别为2.06 μM与1.91 μM),适用于HIV感染研究。
T36659 Boromycin

Boromycin is a boron-containing macrolide antibiotic that has been found in Streptomyces. Boromycin inhibits growth of B. subtilis (MIC = 0.05 μg/ml) and induces efflux of potassium ions from B. subtilis without affecting Na+/K+-ATPase activity. It decreases the synthesis of protein, RNA, and DNA in B. subtilis when used at a concentration of 0.05 μg/ml. It inhibits the growth of B. halodurans (MIC = 10 ng/ml) and inhibits the futalosine pathway of menaquinone synthesis in B. halodurans. Boromyc...
T75783 Apelin-36(human) TFA

Apelin-36(human) TFA 是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂,EC50为 20 nM。Apelin-36(human) TFA 对 HEK 293 细胞表达的人 APJ 受体有很高的亲和力 (pIC50=8.61)。Apelin-36(human) TFA 与两种主要的生物活性有关:心血管和代谢。Apelin-36(human) TFA 抑制 HIV-1和 HIV-2进入表达 APJ 的 NP2/CD4细胞。
T73987 Pradimicin A

Pradimicin A (PRM-A) 是一种有效的抗真菌剂,对褶假丝酵母的 MIC 为 4 μg/mL。Pradimicin A 对 SARS-CoV 病毒,人类免疫缺陷病毒 (HIV) 和其他包膜病毒具有抗病毒活性。Pradimicin A 具有聚集性,在 Ca2+离子存在时能够识别 d-Man。
T83769 TC 14012 hydrochloride

H-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2

TC 14012是一种化学肽模拟的拮抗剂,针对趋化因子(C-X-C motif)受体4(CXCR4;IC50 = 2.9 nM)和CXCR7激动剂。它能在表达CXCR7的HEK293T细胞中诱导β-arrestin招募(EC50 = 350 nM)。TC 14012可减少HIV在MT-4细胞中的细胞病理效应(EC50 = 0.4 nM),并以CXCR4依赖的方式抑制HIV在体外进入(IC50 = 19.3 nM)。它还能抑制由趋化因子(C-X-C motif)配体12(CXCL12)在MDA-MB-231乳腺癌细胞和人脐静脉内皮细胞(HUVECs)中诱导的迁移,当使用浓度范围从10到1,000 nM时。在通过左前降(LAD)冠状动脉结扎诱导的急性心肌梗死小鼠模型中,TC 14012(10 mg/kg)能减少梗死面积。
T37750 Benanomicin B (formate)

Benanomicin B is a microbial metabolite that has been found inActinomycetesand has antifungal, fungicidal, and antiviral activities.1,2It is active against a variety of mammalian and plant pathogenic fungi, includingC. albicans,T. mentagrophytes,C. neoformans, andP. oryzae(MICs = 1.56-50 μg/ml).1Benanomicin B inhibits HIV-1 viral infection in MT-4 cells in a concentration-dependent manner.2 1.Takeuchi, T., Hara, T., Naganawa, H., et al.New antifungal antibiotics, benanomicins A and B from an act...
T37749 Benanomicin A

Benanomicin A is a microbial metabolite that has been found inActinomycetesand has antifungal, fungicidal, and antiviral activities.1,2It is active against a variety of mammalian and plant pathogenic fungi, includingC. albicans,T. mentagrophytes,C. neoformans,P. oryzae, andA. niger(MICs = 3.13-50 μg/ml).1Benanomicin A inhibits HIV-1 viral infection in MT-4 cells in a concentration-dependent manner.2 1.Takeuchi, T., Hara, T., Naganawa, H., et al.New antifungal antibiotics, benanomicins A and B fr...
T37344 5,6-dimethyl-2-Thiouracil

5,6-dimethyl-2-Thiouracil is a heterocyclic building block that has been used in the synthesis of anti-HIV-1 pyrimidinones.1 It has also been used as an internal standard for the quantification of thyreostats, including 2-thiouracil, in bovine plasma.2 |1. Navrotskii, M.B. Synthesis and anti-HIV-1 activity of new 2-[(2-phthalimidoethyl)thio]-4(3H)-pyrimidinone derivatives. Pharm. Chem. J. 39(9), 466-467 (2005).|2. Schmidt, K.S. In-house validation and factorial effect analysis of a liquid chroma...
T14208 AMD 3465

GENZ-644494

HIV Protease Microbiology/Virology; Proteases/Proteasome
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC
T37347 6'-Sialyllactose Sodium Salt

6'-Sialyllactose Sodium Salt,6'-N-Acetylneuraminyl-D-lactose

6'-Sialyllactose consists of the monosaccharide N-acetylneuraminic acid linked to the galactosyl subunit of lactose at the 6 position. This connection is at the 3 position in the related compound, 3’-sialyllactose. Both are major milk oligosaccharides that avidly bind several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus.[1],[2],[3],[4],[5],[6] These compounds can be used to differentiate and characterize the binding domains of viruses that recognize N-acetylne...
T38103 Defensin HNP-3 (human) (trifluoroacetate salt)

Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties. It induces lysis of mammalian cells when used at a concentration of 25 μg/mL. It also inhibits growth of E. faecalis (ED50 = 100 nM) and clinical isolates of P. aeruginosa (MIC90 = 4 μM). HNP-3 binds to recombinant HIV-1 envelope glycoprotein (gp120) and human CD4 (Kds = 52.8 and 34.9 nM, respectively). It also binds to recombinant, immobilized human surfactant protein D (SP-D; Kd...
T11693 IT1t

Others Others
IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist.
T16973 TAK-220

HIV Protease Microbiology/Virology; Proteases/Proteasome
TAK-220 is a selective and orally bioavailable CCR5 antagonist (IC50s: 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively).
T35406 α-MSH TFA

α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2α-MSH (100 pM) reducesS. aureuscolony formation andC. albicansgerm tube fo...
T36574 GW841819X

GW841819X

GW841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomains. GW841819X was a single enantiomer but of undefined chirality at the 4-position of the benzodiazepine ring3. GW841819X and JQ1 were recently discovered that bind to the acetyl-lysine binding pocket of BET bromodomains with Kd ranges from 50 to 370 nM [1]. GW841819X bounded to both the individual BD1 and BD2 domains with affinities of 46 and 52.5 nM, respectively. GW841819X-Brd3 interaction was estimated to be around 70...
T35904 O-11

O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface gl...

化合物

HIV-IN-4
Cat.No: T60426
Synonym:
Target:
HIV-1 protease-IN-4
Cat.No: T74488
Synonym:
Target:
Mavorixafor
Cat.No: TQ0174
Synonym: AMD-070
Target: CXCR
HIV-1 inhibitor-54
Cat.No: T67833
Synonym:
Target: HIV Protease
Lenacapavir
Cat.No: T11465
Synonym: GS-6207
Target: Others, HIV Protease
Gamibetal
Cat.No: T0028
Synonym: 3-Hydroxy-GABA,4-氨基-3-羟基丁酸,4-Amino-3-hydroxybutyric Acid
Target: HIV Protease
Apricitabine
Cat.No: T14313
Synonym: AVX754,SPD754
Target: HIV Protease, DNA/RNA Synthesis
ZK 756326
Cat.No: T3360
Synonym: ZK756326 2HCl
Target: CCR
AMD 3465 hexahydrobromide
Cat.No: T7208
Synonym: GENZ-644494 (hexahydrobromide)
Target: HIV Protease, CXCR
IT1t dihydrochloride
Cat.No: T11693L
Synonym:
Target: CXCR
Mavorixafor trihydrochloride
Cat.No: T10296
Synonym: AMD-070 trihydrochloride
Target: HIV Protease
4'-Ethynyl-2'-deoxyadenosine
Cat.No: T10141
Synonym:
Target: Others
Loviride
Cat.No: T15776
Synonym: R 89439
Target: Others
HIV-1 inhibitor-31
Cat.No: T62070
Synonym:
Target:
3'-Deoxy-4-thiothymidine
Cat.No: T29393
Synonym: Thymidine, 3'-deoxy-4-thio-,Ddthds
Target:
D77
Cat.No: T15045
Synonym:
Target: Others
HIV-1 inhibitor-33
Cat.No: T62353
Synonym:
Target:
HIV-1 inhibitor-34
Cat.No: T62782
Synonym:
Target:
Reverse transcriptase-IN-4
Cat.No: T72206
Synonym:
Target:
HIV-1 inhibitor-28
Cat.No: T63499
Synonym:
Target:
HIV-1 inhibitor-15
Cat.No: T61797
Synonym:
Target:
Dolutegravir SR Isomer
Cat.No: T71009
Synonym:
Target:
Dolutegravir RR Isomer
Cat.No: T70881
Synonym:
Target:
HIV-1 inhibitor-29
Cat.No: T63962
Synonym:
Target:
KRH-1636
Cat.No: T69081
Synonym:
Target:
HIV-1 inhibitor-24
Cat.No: T62430
Synonym:
Target:
HIV-1 inhibitor-58
Cat.No: T78925
Synonym:
Target:
Boromycin
Cat.No: T36659
Synonym:
Target:
Apelin-36(human) TFA
Cat.No: T75783
Synonym:
Target:
Pradimicin A
Cat.No: T73987
Synonym:
Target:
TC 14012 hydrochloride
Cat.No: T83769
Synonym: H-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2
Target:
Benanomicin B (formate)
Cat.No: T37750
Synonym:
Target:
Benanomicin A
Cat.No: T37749
Synonym:
Target:
5,6-dimethyl-2-Thiouracil
Cat.No: T37344
Synonym:
Target:
AMD 3465
Cat.No: T14208
Synonym: GENZ-644494
Target: HIV Protease
6'-Sialyllactose Sodium Salt
Cat.No: T37347
Synonym: 6'-Sialyllactose Sodium Salt,6'-N-Acetylneuraminyl-D-lactose
Target:
Defensin HNP-3 (human) (trifluoroacetate salt)
Cat.No: T38103
Synonym:
Target:
IT1t
Cat.No: T11693
Synonym:
Target: Others
TAK-220
Cat.No: T16973
Synonym:
Target: HIV Protease
α-MSH TFA
Cat.No: T35406
Synonym:
Target:
GW841819X
Cat.No: T36574
Synonym: GW841819X
Target:
O-11
Cat.No: T35904
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T4S0797 Berberine

小檗碱,Berberin,Umbellatine,黄连素

Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶,具有抗肿瘤特性。
T72533 4-Deoxy-4α-phorbol

4-Deoxy-4α-phorbol 是在 E. desmondi 中发现的一种四环二萜类物质。4-Deoxy-4α-phorbol 可用于半合成 HIV-1诱导的 MT-4 细胞的细胞病理学效应抑制剂和 4α-山梨醇酯。
T36438 Sporogen-AO 1

Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3 1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(...
T72429 α-Lipoic Acid sodium

Thioctic acid sodium,DL-α-Lipoic acid sodium,Thioctic acid sodium ; (±)-α-Lipoic acid sodium ; DL-α-Lipoic acid sodium,(±)-α-Lipoic acid sodium

α-Lipoic Acid (Thioctic acid) sodium 是一种抗氧化剂,是线粒体酶复合物的重要辅助因子。α-Lipoic Acid sodium 可抑制NF-κB 依赖性的HIV-1LTR 活化。α-Lipoic Acid sodium 诱导内质网应激 (ERS) 介导的肝癌细胞凋亡 (apoptosis)。α-Lipoic Acid sodium 可与CPUL1 合成自组装的纳米聚合体 CPUL1-LA NA,其抗肿瘤效果优于 CPUL1。
T36000 3-Hydroxyterphenyllin

3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi...

天然产物

Berberine
Cat.No: T4S0797
Synonym: 小檗碱,Berberin,Umbellatine,黄连素
Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy
4-Deoxy-4α-phorbol
Cat.No: T72533
Synonym:
Target:
Sporogen-AO 1
Cat.No: T36438
Synonym:
Target:
α-Lipoic Acid sodium
Cat.No: T72429
Synonym: Thioctic acid sodium,DL-α-Lipoic acid sodium,Thioctic acid sodium ; (±)-α-Lipoic acid sodium ; DL-α-Lipoic acid sodium,(±)-α-Lipoic acid sodium
Target:
3-Hydroxyterphenyllin
Cat.No: T36000
Synonym:
Target:
TargetMol Loading
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