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CD45 Protein, Human, Recombinant (hFc)

CD45 Protein, Human, Recombinant (hFc)

产品编号 TMPY-00711
别名: GP180, L-CA, LY5, T200, protein tyrosine phosphatase, receptor type, C, LCA, CD45R, CD45, B220

The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. CD45 is found expression specifically in hemotopietic cells. CD45 consists of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It serves as an essential regulator of T-cell and B-cell antigen receptor signaling through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling and it also can suppress JAK kinases.

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CD45 Protein, Human, Recombinant (hFc) Chemical Structure
CD45 Protein, Human, Recombinant (hFc), CAS N/A
规格 价格/CNY 货期 数量
100 μg ¥ 3,820 5日内发货
1 mg ¥ 24,900 5日内发货

CD45 Protein, Human, Recombinant (hFc) 的其他形式现货产品:

B220 CD45 Protein, Human, Recombinant (aa 1-529, His) CD45 Protein, Human, Recombinant (aa 26-577, His)
产品目录号及名称: CD45 Protein, Human, Recombinant (hFc) (TMPY-00711)
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参考文献
产品描述 The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. CD45 is found expression specifically in hemotopietic cells. CD45 consists of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It serves as an essential regulator of T-cell and B-cell antigen receptor signaling through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling and it also can suppress JAK kinases.
别名 GP180, L-CA, LY5, T200, protein tyrosine phosphatase, receptor type, C, LCA, CD45R, CD45, B220
分子量 71.1 kDa (predicted)

存储

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

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TargetMol Library Books参考文献

1. Zola H,et al.(2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5. 2. Ho IC,et al.(2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35. 3. Matesanz-Isabel J,et al.(2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12. 4. Irie-Sasaki J,et al.(2001) CD45 is a JAK phosphatase and negatively regulates cytokine receptor signaling. Nature. 409: 349-54.

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Keywords

CD45 Protein, Human, Recombinant (hFc) T-200 GP180 B-220 CD 45 LY 5 B 220 GP-180 L-CA LY5 T200 protein tyrosine phosphatase, receptor type, C GP 180 CD-45 T 200 LY-5 LCA CD45R CD45 B220 Inhibitor inhibitor inhibit

 

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