Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Nigericin sodium salt 是来自吸水链霉菌的抗生素，是一种 NLRP3 激活剂。Nigericin sodium 是一种阳离子离子载体，可抑制高尔基体功能并抑制革兰氏阳性菌的生长。 它还可以防止病毒激活并触发 NALP3 炎性体的激活。
| 产品描述 | Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus and is a NLRP3 activator.Nigericin sodium is a cationic ionophore that inhibits Golgi function and suppresses growth of gram positive bacteria. It also prevents viral activation and triggers activation of the NALP3 inflammasome. |
| 体内活性 | A 48-hr exposure of human erythrocytes to nigericin significantly increased the percentage of annexin-V-binding cells (0.1-10 nM), significantly decreased forward scatter (0.1-1 nM), significantly decreased cytosolic pH (0.1-1 nM) and significantly increased Fluo3 fluorescence (0.1-10 nM).?Nigericin (1 nM) slightly, but significantly, increased ROS, but did not significantly modify ceramide abundance.?The effect of nigericin on annexin V binding was significantly blunted, but not abolished by removal of extracellular Ca(2+).?The nigericin-induced increase in [Ca(2+)]i and annexin V binding was again significantly blunted but not abolished by the Na(+)/H(+) exchanger inhibitor cariporide (10 μM).?Nigericin triggers eryptosis, an effect paralleled by ROS formation, in part dependent on stimulation of Ca(2+) entry, and involving the cariporide-sensitive Na(+)/H(+) exchanger[1]. |
| 别名 | 尼日利亚菌素, 尼日利亚菌素钠盐 |
| 分子量 | 746.94 |
| 分子式 | C40H67NaO11 |
| CAS No. | 28643-80-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 3mg/mL(4.02 mM), Need ultrasonic
Methanol: 122 mg/mL (163.33mM)
Ethanol: 47 mg/mL (62.92mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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剂量换算对于不同动物的给药剂量换算，您也可以参考 更多...
体内实验配液计算器请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法： 比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)， 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300， 混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。
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您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。
Nigericin sodium salt 28643-80-3 Immunology/Inflammation Membrane transporter/Ion channel Microbiology/Virology NF-Κb NOD-like Receptor (NLR) NOD Antibiotic Potassium Channel Antibacterial Inhibitor Nigericin Bacterial 尼日利亚菌素 尼日利亚菌素钠盐 inhibit KcsA inhibitor
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