Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KH7 是腺苷酸环化酶 (sAC) 特异性的可溶性抑制剂,也是一种 cAMP 抑制剂。它对重组纯化的人类 sACt 蛋白和细胞试验中异源表达的 sACt 的 IC50 为 3 到 10 μM 之间。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 793 | 现货 | ||
2 mg | ¥ 1,190 | 现货 | ||
5 mg | ¥ 1,970 | 现货 | ||
10 mg | ¥ 3,180 | 现货 | ||
25 mg | ¥ 5,220 | 现货 | ||
50 mg | ¥ 7,380 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,990 | 现货 |
产品描述 | KH7 is a soluble inhibitor of adenylyl cyclase (sAC)-specific. It has IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibitor. |
靶点活性 | sAC:3-10 μM |
体外活性 | KH7 prevents the generation of CaSF. KH7 (10 μM) blocks this capacitation-induced cAMP increase. At higher concentrations (50 μM), 5- to 10-fold above its IC50 but still selective for sAC relative to tmACs, KH7 resulted in a significant decrease in the basal cAMP accumulation in sperm regardless of the incubation medium. The myocytes exert a negative inotropic effect (NIE) of approximately 20%, in the presence of KH7. This suggesting that sAC is involved in the normal generation of basal cardiac contractility [1,2]. |
分子量 | 419.3 |
分子式 | C17H15BrN4O2S |
CAS No. | 330676-02-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 0.1 mg/mL (insoluble)
DMSO: 100 mg/mL (238.49 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3849 mL | 11.9246 mL | 23.8493 mL | 59.6232 mL |
5 mM | 0.477 mL | 2.3849 mL | 4.7699 mL | 11.9246 mL | |
10 mM | 0.2385 mL | 1.1925 mL | 2.3849 mL | 5.9623 mL | |
20 mM | 0.1192 mL | 0.5962 mL | 1.1925 mL | 2.9812 mL | |
50 mM | 0.0477 mL | 0.2385 mL | 0.477 mL | 1.1925 mL | |
100 mM | 0.0238 mL | 0.1192 mL | 0.2385 mL | 0.5962 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
KH7 330676-02-3 GPCR/G Protein Neuroscience cAMP AChR inhibit KH-7 Adenylate Cyclase Adenylyl cyclase Inhibitor KH 7 inhibitor