Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hypromellose (HPMC) 是一种水溶性的亲水性非离子纤维素醚。
产品描述 | Hypromellose (HPMC) is a water-soluble hydrophilic, non-ionic cellulose ether. |
体外活性 | Hypromellose (hydroxypropylmethylcellulose) has been used in sustained-release pharmaceutical products for many years. These polymers hydrate on contact with water to produce a viscous gel barrier within and surrounding the tablet when used in matrix tablets. The properties of hypromellose that affect the rate of drug release include the rate of diffusion of water into the dry polymer, the rate of hypromellose hydration and gel formation, the viscosity of the hydrated hypromellose, and rate of hypromellose gel erosion [2]. Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect [1]. |
体内活性 | Punctal occlusion using hypromellose 2% is a low-cost and safe additional treatment for dry eye. Fluorescein and rose bengal staining tests show that there was a significant reduction in signs after occlusion using hypromellose [3]. Hypromellose is effective in improving blood glucose metabolism and suppressing oxidative stress in mice fed with a high-fat diet. The antihyperglycemic and antioxidative effects of hypromellose could be partly attributed to the regulation of hepatic glucose-regulating enzyme activities and activation of the hepatic and erythrocyte antioxidant enzymes [4]. |
别名 | Celacol HPM 5000, HPMC, 羟丙甲纤维素, (Hydroxypropyl)methyl cellulose |
分子量 | 1261.44 |
分子式 | C56H108O30 |
CAS No. | 9004-65-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12.61 mg/mL (10 mM), Sonication is recommended.
H2O: 9 mg/mL, Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.7927 mL | 3.9637 mL | 7.9274 mL | 19.8186 mL |
5 mM | 0.1585 mL | 0.7927 mL | 1.5855 mL | 3.9637 mL | |
10 mM | 0.0793 mL | 0.3964 mL | 0.7927 mL | 1.9819 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Hypromellose 9004-65-3 Others Celacol HPM 5000 Celacol HPM5000 HPMC inhibit 羟丙甲纤维素 (Hydroxypropyl)methyl cellulose Inhibitor Celacol HPM-5000 inhibitor