Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CMS-121 是喹诺酮衍生物,对乙酰辅酶 A 羧化酶 1 具有抑制作用,具有口服活性。CMS-121具有保护 HT22 细胞免受缺血和氧化损伤的活性,EC50分别为7 nM 和200 nM。CMS-121具有强大的抗炎,抗氧化,神经保护和肾保护作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 367 | 现货 | ||
5 mg | ¥ 618 | 现货 | ||
10 mg | ¥ 925 | 现货 | ||
25 mg | ¥ 1,740 | 现货 | ||
50 mg | ¥ 2,600 | 现货 | ||
100 mg | ¥ 3,910 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 678 | 现货 |
产品描述 | CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activities. |
体外活性 | CMS-121 can increase acetyl-CoA in cells. CMS-121 (1 μM; 4 hours; HT22 cells) treatment also increases the phosphorylation of ACC1 at serine 79.[1]. |
体内活性 | CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism. CMS-121 (~20 mg/kg; p.o; daily; for 4 months; female SAMP8 mice) treatment decreases cognitive decline and metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. [1]. |
别名 | CMS121 |
分子量 | 321.37 |
分子式 | C20H19NO3 |
CAS No. | 1353224-53-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (155.58 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.1117 mL | 15.5584 mL | 31.1168 mL | 77.792 mL |
5 mM | 0.6223 mL | 3.1117 mL | 6.2234 mL | 15.5584 mL | |
10 mM | 0.3112 mL | 1.5558 mL | 3.1117 mL | 7.7792 mL | |
20 mM | 0.1556 mL | 0.7779 mL | 1.5558 mL | 3.8896 mL | |
50 mM | 0.0622 mL | 0.3112 mL | 0.6223 mL | 1.5558 mL | |
100 mM | 0.0311 mL | 0.1556 mL | 0.3112 mL | 0.7779 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CMS-121 1353224-53-9 Metabolism Acetyl-CoA Carboxylase ACC, Acetyl Coenzyme A Carboxylase CMS 121 disease neuroprotective inhibit anti-inflammatory mitochondrial Alzheimer's antioxidative acetylation Inhibitor H3K9 CMS121 dementia ACC1 inhibitor