Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AFMK (Formyl-N-acetyl-5-methoxykynurenamine) 是褪黑激素的活性代谢物,具有抗氧化和自由基清除活性。 AFMK 是一种凋亡调节剂,可提高吉西他滨在 PANC-1 细胞中的抗肿瘤作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 397 | 现货 | ||
2 mg | ¥ 598 | 现货 | ||
5 mg | ¥ 873 | 现货 | ||
10 mg | ¥ 1,320 | 现货 | ||
25 mg | ¥ 2,160 | 现货 | ||
50 mg | ¥ 3,220 | 现货 | ||
100 mg | ¥ 4,690 | 现货 | ||
500 mg | ¥ 9,830 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 795 | 现货 |
产品描述 | AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine in PANC-1 cells. |
体外活性 | In PANC-1 cell, AFMK in combination with Gemcitabine increases the inhibition of the production of HSP70 from 0.47 (Gemcitabine alone) to 0.13 (10 nM AFMK), 0.08 (0.1 nM AFMK) and 0.01 (0.001 nM AFMK)[1]. AFMK pretreatment significantly inhibits DNA damage and shows a very high hydroxyl radical scavenging potential with an IC50 of 338.08 nM[3]. |
体内活性 | In male C57BL mice, AFMK (10 mg/kg; i.p.) significantly reverses radiation-induced decline in the total antioxidant capacity of plasma. Pretreatment of AFMK shows a significantly lower value of comet tail length and % DNA in tail[3]. |
别名 | Formyl-N-acetyl-5-methoxykynurenamine, Acetyl-N-formyl-5-methoxykynurenamine |
分子量 | 264.28 |
分子式 | C13H16N2O4 |
CAS No. | 52450-38-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (189.19 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.7839 mL | 18.9193 mL | 37.8387 mL | 94.5966 mL |
5 mM | 0.7568 mL | 3.7839 mL | 7.5677 mL | 18.9193 mL | |
10 mM | 0.3784 mL | 1.8919 mL | 3.7839 mL | 9.4597 mL | |
20 mM | 0.1892 mL | 0.946 mL | 1.8919 mL | 4.7298 mL | |
50 mM | 0.0757 mL | 0.3784 mL | 0.7568 mL | 1.8919 mL | |
100 mM | 0.0378 mL | 0.1892 mL | 0.3784 mL | 0.946 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
AFMK 52450-38-1 Apoptosis Metabolism oxidation-reduction Free radical scavengers Antioxidant Endogenous Metabolite Formyl-N-acetyl-5-methoxykynurenamine Acetyl-N-formyl-5-methoxykynurenamine Inhibitor inhibitor inhibit