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VDAC

Voltage-dependent anion channels, or mitochondrial porins, are a class of porin ion channel located on the outer mitochondrial membrane. There is debate as to whether or not this channel is expressed in the cell surface membrane. This major protein of the outer mitochondrial membrane of eukaryotes forms a voltage-dependent anion-selective channel (VDAC) that behaves as a general diffusion pore for small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30–40 mV. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules.

Cat. No.	Product Name	CAS No.	Purity
T13287	VBIT-4 化合物VBIT-4	2086257-77-2	99.93%
T13287	VBIT-4 是一种电压依赖性阴离子通道 1 (VDAC1) 寡聚化抑制剂（Kd：17 μM）。 VBIT-4 可用于治疗凋亡相关疾病（如神经退行性疾病和心血管疾病）。
T1765	Erastin 化合物Erastin	571203-78-6	99.75%
T1765	Erastin 是一种作用于线粒体 VDAC 的铁死亡激活剂。它在体外诱导铁死亡细胞死亡。
T8215	VBIT-12 化合物VBIT-12	2089227-65-4	99.45%
T8215	VBIT-12 是一种有效的 VDAC1 抑制剂。
T18975	DIDS sodium salt 化合物DIDS sodium salt	67483-13-0	99.34%
T18975	DIDS sodium salt 是有效的ABCA1和VDAC1双抑制剂。
T3572	NSC 15364 化合物1,3-Bis(4-aminophenyl)urea	4550-72-5	97.22%
T3572	NSC 15364 是一种VDAC1寡聚化和细胞凋亡抑制剂。