trafficking

Ceapin-A7 是内质网应激 ATF6α信号的选择性阻断剂(IC50:0.59 μM)，可用于探讨 ATF6α 促细胞活化的机制及其在病理环境中的作用。

Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) 是一种植物毒素蓖麻毒素抑制剂，它保护 HeLa 细胞免受蓖麻毒素、Stx1 和 Stx2 的侵害，选择性地阻断早期内体蛋白质-高尔基体界面处的逆行毒素运输。

PD 128042 (CI 976) 是口服有效的ACAT (酰基辅酶 A: 胆固醇酰基转移酶)选择性抑制剂。它也是LPAT(溶血磷脂酰基转移酶) 抑制剂。它抑制高尔基体相关 LPAT 活性 (IC50=15 μM)。它抑制多种膜运输步骤，包括在内吞和分泌途径中发现的步骤。

Elexacaftor (VX-445) 是一种囊性纤维化跨膜电导调节因子 (CFTR) 校正剂。它促进CFTR 的加工和转运，增加细胞表面CFTR 的数量,改善 Phe508del CFTR 蛋白加工和运输。

UNC10217938A HCl (UNC7938 HCl) 是具有寡核苷酸 (oligonucleotides) 增强作用的 3-deazapteridine 类似物， 通过调节寡核苷酸在细胞内的运输和从内体中的释放来增强寡核苷酸的作用。UNC10217938A HCl 还增强了 siRN 和反义寡核苷酸的作用。

LKM38是一种新型的重氮烷基胆固醇探针，是一种有前途的胆固醇模拟物。LKM38既能维持抗胆固醇细胞的生长，又能适当地调节关键的胆固醇平衡途径。LKM38可以作为研究胆固醇蛋白相互作用和贩运的有力工具。

Lumacaftor (VRT 826809) 是一种 CFTR 调节剂，可纠正 CFTR 蛋白的折叠和运输。它增强了 FRT 细胞中 F508del-CFTR 蛋白的成熟，EC50为100 nM。

Endosidin 7(内苷 7)是一种特异性的胼胝质（Callose）合成酶抑制剂，在植物细胞质分裂期间组织胼胝质沉积，不影响间期或细胞骨架组织期间的内膜运输，阻止细胞后期分裂。

(E)-KPT330 是一种 CRM1 选择性核输出抑制剂。它抑制细胞核中的蛋白质运输并诱导间皮瘤细胞中的细胞周期停滞和凋亡。

Navarixin (MK-7123) 是一种可口服的 CXCR1和 CXCR2变构拮抗剂，对猕猴 CXCR1的 Kd 值为 41 nM，对大小鼠和猕猴 CXCR2的 Kd 值分别为 0.20、0.20 和 0.08 nM。

CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively.

G0507 is a pyrrolopyrimidinedione compound that serves as a potent inhibitor of Escherichia coli growth, effectively inducing the extracytoplasmic σE stress response. It acts as a valuable chemical probe, specifically designed to dissect lipoprotein trafficking in Gram-negative bacteria. Notably, G0507 demonstrates strong inhibitory activity against the LolCDE ABC Transporter.

Retro-2 cycl 是一种抗病毒剂，是一种逆行运输抑制剂，抑制 JCPyV（IC50s：54 μM）和 HPV16 假病毒（IC50s：160 μM）。

DHQZ 36 is a potent retrograde trafficking inhibitor. It has potent anti-parasite activity. DHQZ 36 inhibits Leishmania amazonensis infection in macrophages (EC50: 13.63 μM).

TRV045 是一种选择性激活鞘氨醇-1-磷酸 (sphingosine-1-phosphate) 亚型 1 受体的激动剂，并且不会影响淋巴细胞运输。TRV045 显示出抗癫痫活性。

biotinylated anandamide analog acts as a probe for visualizing the accumulation and intracellular trafficking of anandamide

CESTRIN is a cellulose synthase trafficking probe that acts by inhibiting cellulose deposition and interferes with the trafficking of cellulose synthase complexes and their associated proteins KORRIGAN1 and POM2/CSI1.

D011-2120 is an agent of antiviral that acts by blocking microtubule polymerization, disrupting the Golgi complex and inhibiting viral trafficking to the plasma membrane during virus egress.

EGA 抑制致命毒素的中毒，并阻止多种其他酸依赖性细菌毒素和病毒进入哺乳动物细胞。EGA 是研究膜运输的有力工具，可用于治疗传染病。

Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.

PPQ-581 is an anti-influenza agent. PPQ-581 interrupts the crucial RNP trafficking, resulting in influenza replication inhibition, preventing virus-induced cytopathic effects.

SPM-242 is an orthosteric agonist of Sphingosine 1-phosphate (S1P) and a bitopic antagonist. S1P is a lysophospholipid signaling molecule that regulates important biological functions, including vascular development and lymphocyte trafficking, by activat

KM11060 是 F508del-CFTR 运输缺陷的新型校正剂，可纠正 F508del-CFTR 运输，增加质膜上功能性 CFTR 的数量。它可用于 F508del-CFTR 加工缺陷的研究和囊性纤维化治疗剂的开发。

PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer. 3,5-dimethyl PIT-1 is a dimethyl analog of PIT-1, the selective inhibitor of PIP3 Akt PH domain binding, that is designed for more favorable solubility in vivo. 3,5-dimethyl PIT-1 inhibits PI3K Akt signaling (IC50 = 27 μM), suppressing PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 36 μM). 4T1 breast cancer growth is significantly attenuated in BALB c mice with a dose of 1 mg kg of 3,5-dimethyl PIT-1 per day.