neuropeptide y , human

Neuropeptide Y (13-36), amide, human is a neuropeptide Y receptor agonist.

Neuropeptide Y (29-64), amide, human acetate 参与阿尔茨海默病 (AD) 并保护大鼠皮质神经元免受 β-淀粉样蛋白毒性。

Neuropeptide Y (NPY) (3-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion. NPY (3-36) is an endogenous peptide produced by cleavage of NPY by dipeptidyl peptidase 4 (DPP-4). It binds selectively to the NPY receptor Y2 (Ki = 0.41 nM in CHP 234 cells) over the Y1 receptor, where it does not bind at concentrations up to 1 μM. NPY (3-36) (0.1 nM) increases migration of human umbilical vein endothelial cells (HUVECs) by 80% after 12 hours in an in vitro wound closure assay. NPY (3-36) corresponds to residues 3-36 of the human and rat protein sequence.

Neuropeptide Y (3-36) (human, rat) is a metabolite of neuropeptide Y (NPY) generated by dipeptidyl peptidase-4 (DPP4). Known as a selective Y2 receptor agonist, Neuropeptide Y (3-36) (human, rat) effectively reduces the release of norepinephrine via the Y2 receptor[1][2].

Neuropeptide Y (human) TFA, a compound implicated in Alzheimer's disease (AD), exhibits protective effects against β-Amyloid toxicity in rat cortical neurons.

[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) 是Y1受体的选择性激动剂。与阿尔茨海默病相关，该化合物能够保护老鼠皮质神经元免受淀粉样蛋白毒性的损害。

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA 是一种针对神经肽 YY1受体的特定激动剂，并亦能够激活Y4和Y5受体。该化合物能提高麻醉大鼠的血压并增加食物摄入。

Neuropeptide Y (1-24) (human) 是一种神经肽，它能够抑制大鼠输精管电刺激引发的抽搐反应，同时在体内刺激 N-methyl-D-aspartate (NMDA) 促使大鼠海马背侧 CA3 区神经元激活。

Neuropeptide Y (29-64), amide, human is a biologically active 36-amino acid peptide.

Neuropeptide Y (29-64), amide, human (TFA) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.It is showed that Neuropeptide Y (29-64), amide, human (TFA) is able to protect cortical neurons from Aβ25-35 t

High affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors.

Pancreatic Polypeptide (human) acetate 是一种 C 末端酰胺化的 36 个氨基酸肽，可作为神经肽 Y (NPY) Y4/Y5 受体激动剂。

RFRP3(human) acetate(311309-27-0 free base) 是一种人类 GnIH 肽同源物，是一种有效的促性腺激素分泌抑制剂，可抑制 Ca2+ 动员。它是一种 NPFF1 受体激动剂，它抑制毛喉素诱导的 cAMP 产生，IC50 为 0.7 nM。

α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2α-MSH (100 pM) reducesS. aureuscolony formation andC. albicansgerm tube formationin vitro.3It inhibits endotoxin-, ceramide-, TNF-α-, or okadaic acid-induced activation of NF-κB in U937 cells.1α-MSH reduces IL-6- or TNF-α-induced ear edema in mice.4It also prevents the development of adjuvant-induced arthritis in rats and increases survival in a mouse model of septic shock. Increased plasma levels of α-MSH are positively correlated with delayed disease progression and reduced death in patients with HIV.1 1.Catania, A., Airaghi, L., Colombo, G., et al.α-melanocyte-stimulating hormone in normal human physiology and disease statesTrends Endocrinol. Metab.11(8)304-308(2000) 2.Miwa, H., Gantz, I., Konda, Y., et al.Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptorsJ. Pharmacol. Exp. Ther.273(1)367-372(1995) 3.Cutuli, M., Cristiani, S., Lipton, J.M., et al.Antimicrobial effects of a-MSH peptidesJ. Leukoc. Biol.67(2)233-239(2000) 4.Lipton, J.M., Ceriani, G., Macaluso, A., et al.Antiiinflammatory effect of the neuropeptide a-MSH in acute, chronic, and systemic inflammationAnn. N.Y. Acad. Sci.25(741)137-148(1994)

CART(55-102)(human) TFA，一种与瘦素和神经肽 Y 密切相关的人源饱腹感因子，具有显著的抑制食欲作用。

GR231118是神经肽Y的C末端类似物，作为人神经肽YY受体的高竞争性和相对选择性的拮抗剂（pKi=10.4），并对人类神经肽Y4受体显示出拮抗效果（pEC50=8.6；pKi=9.6），同时是对人及大鼠神经肽YY2与Y5受体的弱激动剂。此外，GR231118对小鼠神经肽YY6受体具有较高亲和力（pKi=8.8）。

Neuropeptide Y (2-36) (porcine) 是一种具有 97.14% 与大鼠/人类同源性的猪源性神经肽。作为一种大鼠神经肽受体激动剂，其对Y5、Y2和Y1受体的EC50值为1.2, 1.6 和 3.4 nM，能显著增加食物摄入量，适用于肥胖和饮食失调研究。

CART (1-39), Human, Rat, 是一种由其1至39个残基构成的神经肽, 具有明显的减少食欲作用, 被认为是鼠类的饱腹因子, 并与瘦素及神经肽Y有着紧密的联系。它能有效抑制正常及饥饿状态下的摄食行为, 同时也能引发焦虑与压力相关的反应。

(Pro34)-Peptide YY (human) 是 Peptide YY/neuropeptide Y 受体的高度 Y1选择性全激动剂。

Peptide YY (PYY) (3-36), human (Peptide YY (3-36)) 是一种肠胃激素肽，可以激动Y2受体，具有降低食欲的功效。

Peptide YY (PYY) (3-36), human acetate（126339-09-1 Free base）是一种NPY(neuropeptide Y) Y2受体激动剂，能够抑制肠道液体分泌和减缓结肠运输来抑制小鼠腹泻。

RFRP-1 (human) acetate(311309-25-8 free base) 是一种有效的内源性 NPFF 受体激动剂（NPFF2 和 NPFF1 的 EC50 值分别为 0.0011 和 29 nM）。它减弱离体大鼠和兔心肌细胞的收缩功能。降低心率、每搏输出量、射血分数和心输出量，并增加大鼠的血浆催乳素水平。 GnIH 同系物。

Potent, selective peptide agonist for the neuropeptide Y Y5 receptor (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki at Y5 = 0.1 - 0.15 nM). Stimulates food intake in vivo.