mers-cov

MERS-CoV-IN-1 对冠状病毒的活性具有优异的抑制作用，可用作预防冠状病毒引起疾病的药物组合物。

Anti-MERS-CoV Spike Antibody (3I167) 是一种靶向MERS-CoV MERS-CoV Spike 的单克隆抗体，是一种 Rabbit IgG 抗体。

Remdesivir (GS-5734) 是一种核苷类似物，一种广谱的抗病毒化合物，通过抑制病毒的 RNA 依赖性 RNA 聚合酶发挥活性。Remdesivir 对埃博拉病毒、SARS 病毒、MERS病毒等均有活性，对 COVID-19 有潜在治疗价值。

Bonducellpin D may show inhibitory activities on the Para3 virus. It also exhibits moderate activity against four tested human cancer cell lines, HepG-2, K562, HeLa, and Du145.

Molnupiravir (EIDD-2801) 是核糖核苷类似物 EIDD-1931 的异丙酯前体药物，具有口服生物利用度。Molnupiravir 可用于 COVID-19 ，季节性和流行性流感的研究，对多种冠状病毒和流感病毒具有广谱的抗病毒活性，例如，SARS-CoV-2，MERS-CoV，SARS-CoV。

EIDD-1931 (Beta-d-N4-hydroxycytidine) 是一种核苷类抗病毒试剂 ，可抑制丙型肝炎病毒、基孔肯亚病毒和委内瑞拉马脑炎病毒的复制活性。

SARS-CoV-2-IN-1 is a potent inhibitor of Mpro(SARS-CoV-2 Mpro, SARS-CoV Mpro and MERS-CoV Mpro with IC50s of 0.67, 0.90 and 0.58 μM, respectively).

PLpro-IN-5 (compound 21) 作为一种PLPro蛋白酶抑制剂，其IC50值达到91.14 nM。此化合物展现了广谱的抗病毒活性，特别是对SARS-CoV、MERS-CoV和SARS-CoV-2有显著的效果。

PAMAM dendrimer G1.5 carboxylate (PAMAM G1.5 carboxylate) sodium 是一种多聚阴离子树枝状聚合物，由端基羧酸钠组成。在MERS‐CoV斑块抑制试验中，PAMAM dendrimer G1.5 carboxylate 显示出40.5%的抗病毒活性。

TDI-015051 是一种口服有效的 SARS-CoV-2 非结构蛋白 14 (SARS-CoV-2 NSP14) 抑制剂，IC50≤0.15 nM。在 Huh-7.5 细胞 (EC50=11.4 nM) 和表达 ACE2-TMPRSS2 的 A549 细胞 (EC50=64.7 nM) 中能够抑制 SARS-CoV-2 NSP14。此外，TDI-015051 对其他冠状病毒，如 α-hCoV-NL63、α-hCoV-229E 和 β-hCoV-MERS，也有抑制作用，IC50分别为 1.7、2.6 和 3.6 nM。通过与SAH稳定的cap口袋结合，TDI-015051 可抑制病毒 RNA 甲基化和病毒复制，并在小鼠模型中显示出抗感染活性。

SARS-CoV-2 Mpro-IN-37 (compound 8r) 是一类抑制 SARS-CoV-2 主蛋白酶 (Mpro) 的物质，其IC50值为 0.0199 μM。对于 SARS-CoV-1 Mpro 和 MERS-CoV Mpro，其IC50值分别为 0.00945 μM 和 0.111 μM。在纳摩尔浓度范围内，SARS-CoV-2 Mpro-IN-37 展示了显著的抗病毒活性，并且不具细胞毒性。

Dihydrotanshinone I (DHTS) 是从丹参中分离到的一种天然产物，可抑制 MERS-CoV，可研究心血管疾病。

Anti-MERS-3A1 mAb (MERS-3A1) is a high-affinity human monoclonal IgG1 antibody derived from CHO cells. It effectively inhibits the interaction between the MERS-CoV spike protein and the DPP4 receptor[1].

Mpro inhibitor N3 hemihydrate is a potent inhibitor of SARS-CoV-2 Mpro with an EC50 of 16.77 μM for SARS-CoV-2. Mpro inhibitor N3 hemihydrate specifically inhibits Mpro from multiple coronaviruses, including SARS-CoV and MERS-CoV. Mpro inhibitor N3 hemihydrate displays inhibition against HCoV-229E, FIPV, and MHV-A59 with individual IC50 of 4.0 μM, 8.8 μM, and 2.7 μM, respectively[1][2]. Mpro inhibitor N3 hemihydrate (0-0.64 μM) is able to penetrate cells to inhibit the replication of IBV viruses, probably at the beginning of infection in embryos[3]. [1]. Jin Z, et al. Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 2020;582(7811):289-293.[2]. Yang H, et al. Design of wide-spectrum inhibitors targeting coronavirus main proteases [published correction appears in PLoS Biol. 2005 Nov;3(11):e428]. PLoS Biol. 2005;3(10):e324.[3]. Wang F, et al. Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design. Sci Rep. 2016;6:22677. Published 2016 Mar 7.

Remdesivir nucleoside monophosphate, a metabolite of Remdesivir, is a potent antiviral compound with nucleoside analogue characteristics. It exhibits effective antiviral activity against both SARS-CoV and MERS-CoV.

MM3122 (MM-3122) 是一种选择性的 II 型跨膜丝氨酸蛋白酶 (TMPRSS2) 抑制剂，IC50为 0.34 nM。MM3122 可以有效阻断 TMPRSS2，从而抑制 SARS-CoV-2 和 MERS-CoV 进入人类细胞。

E 64c (EP 475) 是一种不可逆且可透过膜的半胱氨酸蛋白酶抑制剂，是 E-64 的衍生物。它也是钙离子激活中性蛋白酶抑制剂和组织蛋白酶 C 弱不可逆抑制剂，可抑制 MERS-CoV。

Vincapusine is a natural inhibitor of 3C-like protease (3CLpro), targeting SARS-CoV-2 3CLpro, SARS-CoV 3CLpro and MERS-CoV 3CLpro.

UAWJ9-36-3 is a SARS-CoV-2 Protease inhibitor (IC50 = 54 nM). UAWJ9-36-3 showed potent binding and enzymatic inhibition against the Mpro's from SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-OC43, HCoV-NL63, HCoV-229E, and HCoV-HKU1. UAWJ9-36-3 is a promising candidate to be further developed as a broad-spectrum coronavirus antiviral.

UAWJ9-36-1 is a SARS-CoV-2 Protease inhibitor (IC50 = 51 nM). UAWJ9-36-1 showed potent binding and enzymatic inhibition against the Mpro's from SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-OC43, HCoV-NL63, HCoV-229E, and HCoV-HKU1. UAWJ9-36-1 is a promising candidate to be further developed as a broad-spectrum coronavirus antiviral.

Blancoxanthone is a molecule isolated from plants could also be potential drug candidates against COVID-19. Moreover, these could also show promising inhibitory effects against influenza-parainfluenza viruses, respiratory syncytial virus, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome coronavirus (MERS-CoV).

SARS-CoV-2 MERS Mpro-IN-1 是一种有效的SARS-CoV-2和MERS 主要蛋白酶抑制剂，IC50值分别为 0.10、0.06 µM。

SARS-CoV-2 MERS Mpro-IN-2 是一种有效的 SARS-CoV-2和MERS 主要蛋白酶抑制剂，IC50值分别为 0.21, 0.07 µM。

SARS-CoV-2 3CLpro-IN-10(5d)为一种有效的抗 SARS-CoV-2 3CL 蛋白酶抑制剂，其IC50值仅为190 nM，同时对SARS-CoV-1的IC50值为790 nM，对MERS-CoV的IC50值则为70 nM，显示出广谱的抗病毒活性。