dominant

Methyl 2-hydroxy-4-methylvalerate 是一种镇江芳香醋中主要的挥发性化合物，可用于绘制醋菌群的风味生物合成网络图。

2-Methylcinnamic acid, predominantly trans 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65873，CAS号为 2373-76-4。

3-Bromocinnamic acid, predominantly trans 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T67378。

3,5-Dimethoxycinnamic acid, predominantly trans 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67479，CAS号为 16909-11-8。

EMD57033是一种心脏肌钙蛋白C（cTnC）激活剂，是一种显性的Ca2+增敏剂。EMD57033通过与心脏/慢速骨骼肌钙蛋白C 异构体结合从而发挥促进心脏收缩的功能。

4-Hydroxyphenylpyruvic acid 是一种苯丙氨酸代谢的中间产物，是一种酶抑制剂。

DM-4107 是 Tolvaptan 的主要代谢产物，通过肝脏中的 CYP3A4 酶代谢。在 SCHH 细胞中，DM-4107 抑制人类肝脏转运蛋白 NTCP、BSEP、MRP3、MRP4，其 IC50 分别为 95.6、119、61.2、37.9 μM，并影响胆汁酸的转运能力。DM-4107 可用于常染色体显性多囊肾病（ADPKD）的研究。

HDAC6-IN-43 (compound 26) 为一种高效的HDAC抑制剂，可显著抑制多种HDAC，尤其是HDAC1、HDAC2和HDAC6（IC50< 150 nM），并对HDAC6显示出特别高的敏感性（IC50= 11 nM）。HDAC6-IN-43 可用于常染色体显性多囊肾病（ADPKD）的研究。

TBK1degrader-4 (Compound 30) 是一种靶向TBK1的分子胶 (molecular glue) 降解剂，能够有效抑制囊肿生长，降低炎症，并减少 Ccl2、IFNβ 和 IL-6 等促炎因子的水平。该化合物有望用于常染色体显性多囊肾病 (ADPKD) 的研究。

DM-4103是Tolvaptan的主要代谢物，通过肝脏的CYP3A4酶进行代谢。在SCHH细胞中，DM-4103能够抑制肝脏转运蛋白NTCP、BSEP、MRP2、MRP3、MRP4，其IC50值分别为16.3、4.15、51.0、44.6、4.26 μM，并影响胆汁酸的转运。DM-4103可用于研究常染色体显性多囊肾病 (ADPKD)。

AXT-914 是一种钙敏感受体 (CaSR) 抑制剂，具有对冠状病毒 HCoV 229E 和 SARS-CoV2 的抗病毒活性。它可以降低 CaSR 突变引起的细胞质钙信号传导活性。AXT-914 可用于 Bartter 综合征 5 型、常染色体显性低钙血症 (ADH) 以及冠状病毒感染的研究。

Brr2-IN-3 (Brr2 Inhibitor C9) 是选择性 Brr2解旋酶变构抑制剂。它呈剂量依赖性地抑制解旋酶(IC50:1.3 μM)。

Photoregulin1 is a modulator of Nr2e3. Photoregulin1 slows the progression of photoreceptor degeneration in two common mouse models of autosomal dominant RP, the RhoP23H and the Pde6brd1 mutations.

Hexyl decanoate, the first trail pheromone compound identified in a stingless bee, Trigona recursa. Hexyl decanoate is dominant component of gland secretions.

Nanangenine B is a drimane sesquiterpene that has been found inAspergillus.1It is active againstB. subtilis(IC50= 62 μg/ml) and cytotoxic to NS-1 mouse myeloma cells (IC50= 38 μg/ml). 1.Lacey, H.J., Gilchrist, C.L.M., Crombie, A., et al.Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensisBeilstein J. Org. Chem.152631-2643(2019)

Nanangenine F is a drimane sesquiterpene fungal metabolite that has been found inA. nanangensis.1It is active againstB. subtilis(IC50= 78 μg/ml) and cytotoxic to NS-1, DU145, and MCF-7 cancer and NFF non-cancerous cells (IC50s = 49, 95, 49, and 84 μg/ml, respectively). 1.Lacey, H.J., Gilchrist, C.L.M., Crombie, A., et al.Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensisBeilstein J. Org. Chem.152631-2643(2019)

Nanangenine G is a drimane sesquiterpene that has been found inAspergillus.1It is cytotoxic to NS-1 mouse myeloma cells (IC50= 47 μg/ml). 1.Lacey, H.J., Gilchrist, C.L.M., Crombie, A., et al.Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensisBeilstein J. Org. Chem.152631-2643(2019)

Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo. Brown et al (1999) A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 48 1415 PMID:10389847 |Nugent et al (2001) Potentiation of glucose uptake in 3T3-L1 adipocytes by PPARγ agonists is maintained in cells expressing a PPARγ dominant-negative mutant: evidence for selectivity in the downstream responses to PPARγ activation. Mol.Endocrinol. 15 1729 PMID:11579205 |Way et al (2001) Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor γ agonists. J.Biol.Chem. 276 25651 PMID:11373275

Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant inhibitor of glucosylceramide synthase (GCS). It is utilized in the investigation of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.

GFB-12811 是一种具有口服活性、选择性和高效性的 CDK5 抑制剂，可用于研究常染色体显性遗传性多囊肾病。

Vasopressin V2 receptor antagonist 1 (Compound 4g) 是一种 vasopressin V2receptor (V2R) 拮抗剂 (Ki: 3.8 nM)。Vasopressin V2 receptor antagonist 1 可以用于研究常染色体显性多囊肾病 (ADPKD)。

Dicetrorelix pamoate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently luteinization as indicated by rising progesterone levels. Cetrorelix competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner. Cetrorelix binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion. It competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner......

CDK7-IN-20 是一种有效的、选择性的、不可逆的 CDK7(CDK) 抑制剂，IC50值为 4 nM。CDK7-IN-20 对 CDK7的选择性超过 CDK1、CDK2、CDK3、CDK5、CDK6、CDK9 和 CDK12的 206 倍以上。CDK7-IN-20 具有用于常染色体显性多囊肾病 (ADPKD) 研究的潜力。

mHTT-IN-1 (Example 1) 为针对突变亨廷顿蛋白 (mHTT) 的高效抑制剂，该蛋白具毒性，主导遗传性常染色体显性神经退行性疾病—亨廷顿氏病 (HD) 的发生。mHTT-IN-1 能有效降低 mHTT 水平，其 EC50 值为 0.46 nM。