brain membranes

L-701324 是一种 NMDA 受体，对甘氨酸位点具有高亲和力和选择性，用作口服活性和长效抗惊厥药。

DPCPX (PD 116948) 是一种黄嘌呤衍生物，是一种选择性腺苷 A1 受体的拮抗剂，Ki 值为 0.46 nM。

5-HT3 antagonist 3 是一种高亲和力的 5-HT3 受体拮抗剂。5-HT3 antagonist 3 结合到大鼠脑皮质膜中的 5-HT3 受体，Ki 为 0.25 nM。

(1R,2R)-2-PCCA hydrochloride 是一种具有有效性、选择性和可穿过血脑屏障的 GPR88 受体激动剂，在 WT 小鼠纹状体膜中 EC50 值为1140 n。(1R,2R)-2-PCCA hydrochloride 可用于研究中枢神经系统。

Z-Glycine (Carbobenzoxyglycine) 是一种药物-脂质结合物，旨在促进脑渗透，基于其亲脂性和与生物膜中脂质的相似性。

Phosphatidylethanolamines (bovine) 是从牛脑中分离出来的一种磷脂酰乙醇胺混合物，在 sn-1 和 sn-2 位置上带有不同的脂肪酰基。Phosphatidylethanolamines (bovine) 是在原核生物、哺乳动物、植物和酵母细胞膜中含量均很高的磷脂，约占哺乳动物磷脂总量的 25%。

JW 642 是一种高效的MAGL 抑制剂，对小鼠、大鼠和人源脑细胞膜上MAGL 的IC50值分别为7.6nM、14nM 和3.7nM。

SCH-37370 是一种有效且具有口服活性的血小板活化因子和组胺双重拮抗剂。 Sch 37370 阻断 [3H]pyrilamine 与大鼠脑膜中组胺-H1 受体的结合。 Sch 37370 选择性地抑制 PAF 诱导的人血小板聚集（IC50：0.6 mM），并且还与 PAF 竞争与人肺膜制剂中特定位点的结合（IC50：1.2 mM）。

SR 57227 hydrochloride(SR 57227A ) 是一种有效的、具有口服活性和选择性的 5-HT3 受体激动剂，具有穿越血脑屏障的能力和抗抑郁作用。它对大鼠皮质膜和整个 NG 108-15 细胞或其膜上的 5-HT3 受体结合位点的亲和力，IC50在 2.8 至 250 nM 之间。

GR 159897 is a competitive, brain-penetrated non-peptide NK2 receptor antagonist with anti-tumor effects. GR 159897 inhibits binding of [3H]GR100679 to human NK2-CHO cells and rat colon membranes (pKis: 9.51 and 10, respectively). It can antagonize bronch

Anxiolytic nonsedative agent-1 (TCS 1205) 是一种有效的选择性 GABAA 激动剂。Anxiolytic nonsedative agent-1 对牛脑膜中的 BzR 显示出明显的亲和力，对 α1β2γ2、α2β2γ2、α5β3γ2 的 Kis 分别为 14、121、239 nM。Anxiolytic nonsedative agent-1 在体外表现出 α2 选择性功效，在体内表现出抗焦虑选择性作用。

8-CSC is a dual agent endowed with good hMAO-B inhibitory activity (Ki: 235 nM in baboon liver mitochondria) and A2A affinity (Ki: 36 nM in rat brain striatal membranes receptor).

L-736380 is a CCK-B receptor antagonist. L-736,380 dose-dependently inhibited gastric acid secretion in anesthetized rats (ID(50), 0.064 mg kg) and ex vivo binding of [(125)I]CCK-8S in BKTO mice brain membranes (ED(50), 1.7 mg kg).

PD 122860 is a dihydropyridine with calcium channel blocking and sodium channel stimulating properties. In the rat heart, PD 122860 increased left ventricular contractility, decreased coronary resistance and altered the shape of the electrocardiogram T-wa

KS 5-2 has affinity to isolated synaptic membranes from rat brain.

Levomefolate magnesium is the magnesium salt of the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma. It is transported across th

Dizocilpine Maleate (MK 801) 是一种选择性和非竞争性的 NMDA 受体拮抗剂，Kd 值为 37.2 nM。它用于治疗 NMDA 受体可能发挥重要作用的多种神经退行性疾病或疾病。

N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM). It inhibits serotonin uptake in rat brain synaptosomes with an IC50 value of 22 nM. N-methyl Paroxetine has been used as a precursor in the synthesis of paroxetine and is a potential impurity in commercial preparations of paroxetine.

Ganglioside GM2 is a glycosphingolipid component of cellular membranes, primarily the plasma membrane. Levels of ganglioside GM2 are elevated in the brain of patients with Sandhoff disease, as well as feline and mouse models of the disease. Ganglioside GM2 accumulates in the lysosomes of individuals with Tay-Sachs disease and GM2-activator deficiency, as well as in the CNS of patients with and animal models of mucopolysaccharide storage disorders and Niemann-Pick disease types A, C1, and C2. Ganglioside GM2 mixture contains ganglioside GM2 molecular species with C18:1 and C20:1 sphingoid backbones.

Methylatropine is an antagonist of muscarinic acetylcholine receptors (IC50= <0.1 nM in a radioligand binding assay using isolated porcine brain membranes) and a derivative of atropine .1,2It reduces acetylcholine-induced decreases in blood pressure in rats when administered intravenously with an ED50value of 5.5 μg/kg.2Methylatropine reduces salivation, induces mydriasis, and increases heart rate in dogs.3 1.Schmeller, T., Sporer, F., Sauerwein, M., et al.Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptorsPharmazie50(7)493-495(1995) 2.Brezenoff, H.E., Xiao, Y.-F., and Vargas, H.A comparison of the central and peripheral antimuscarinic effects of atropine and methylatropine injected systemically and into the cerebral ventriclesLife Sci.42(8)905-911(1988) 3.Albanus, L.Central and peripheral effects of anticholinergic compoundsActa Pharmacol. Toxicol. (Copenh)28(4)305-326(1970)

Ganglioside GD1b is an acidic glycosphingolipid that contains two sialic acid residues linked to an inner galactose unit. It is a component of plasma membranes where it packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events. The concentration of ganglioside GD1b in human brain increases with age, constituting 7.85% of total sialic acid in the brain of 0- to 10-year-old subjects and 20.29% in 11- to 30-year-old subjects. Ganglioside GD1b mixture contains ganglioside GD1b molecular species with C18:1 and C20:1 fatty acyl chains.

BTCP 与豚鼠脑膜一起预孵育可增加 [3H]TCP 从 PCP 位点的解离速率。

CCK (26-30) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. The sulfated form of CCK (26-30) inhibits binding of [125I]CCK-33 to guinea pig cortical membranes by 10% when used at a concentration of 0.1 mM.

CCK (26-31) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. The sulfated form of CCK (26-31) inhibits binding of [125I]CCK-33 to guinea pig cortical membranes by 21% when used at a concentration of 0.1 mM.