bak

Bz 423 是一种有效的免疫调节剂，通过激活 Bax 和 Bak 来诱导线粒体外膜通透和细胞色素 c 释放来诱导细胞凋亡。Bz 423 在狼疮小鼠模型中显示出部分活性。

MSN-125 effectively inhibits Bax Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons protect primary neurons against glutamate excitotoxicity. MSN-125 is an effective Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochond

BAK2-66 is a selective antagonist of the dopamine D3 receptor.

BakBH3 (72-87), TAMRA-labeled，是一种具有生物活性的肽类化合物。

This peptide, generated from the BH3 domain of Bak (Flu-BakBH3), has been shown to have high-affinity binding to a surface pocket of the Bcl-XL protein that is required for its death antagonist function.

CAY10526 (BTH) 是 mPGES-1 的选择性抑制剂，可抑制 NF-κB 信号通路。

TCS-PIM-1-4a (SMI-4a) 是一种泛-Pim 激酶抑制剂，可通过激活 AMPK 来阻断 mTORC1的活性。它可杀死多种髓样和淋巴样细胞系，IC50值为 0.8 μM 至 40 μM。

Bakuchiol 是一种从补骨脂种子中提取的植物雌激素，具有抗肿瘤和抗蠕虫特性，以及细胞毒活性和抗菌活性。

Bakuchalcone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124107。

12-Hydroxyisobakuchiol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125549。

Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K Akt-related signaling pathways.

Inbakicept 是一种 IL-15 受体α sushi 结构域与免疫球蛋白 G1（人 Fc 片段）融合蛋白二聚体，是一种 IL-15 超级激动剂蛋白复合物。 Inbakicept 与 IL-15 抗体 Nogapendekin alfa 可以结合形成复合物 Nogapendekin alfa inbakicept (ALT-803)，比例为1：2。ALT-803 具有潜在的抗癌抗肿瘤活性，可用于研究乳腺癌。

1-Oxobakkenolide S 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2562，CAS号为 18456-02-5。

3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3 Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, the opening of the mitochondrial perm

Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.

Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have obvious anti-histamine activities.

Bakkenolide Db may have cytotoxicity.

Bakkenolide III may have cytotoxicity.

Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1 2 activation and inactivated NF-κB signaling.

Bakankosin（compound 2a）是一种单萜糖苷，来源于马钱子。

Nogapendekin alfa inbakicept 是一种 IL-15 超级激动剂，能够激活 NK 细胞和 T 细胞，从而增强抗肿瘤免疫应答，目前正在用于非肌层浸润性膀胱癌 (NMIBC) 的研究。

Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物，是一种NF-κB 的抑制剂，能够抑制 p50 的 DNA 结合活性。

PUMA BH3 (TFA) 是一种 p53 正向凋亡调控因子 (PUMA) BH3 结构域多肽，作为Bak 的直接激活剂，Kd 值为 26 nM。

PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide that acts as a direct activator of Bak with a Kd of 26 nM. This peptide binds Bcl-2, localizes to mitochondria, and induces cytochrome C release.