aminopeptidase n

Betulinic acid (ALS-357) 是从白桦树皮中分离出来的一种五环三萜类天然产物，是真核细胞拓扑异构酶 I 的抑制剂，IC50值为 5 μM，具有抗逆转录病毒、抗疟疾、抗癌和抗炎特性。

Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].

Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N CD13 (IC50 = 25 μM). It is selective for AP-N CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM.

AminopeptidaseN Ligand (CD13) NGR peptide 是靶向CD13的多肽，常见于癌症研究中，用作细胞内传递的载体介质。

Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N) APN 和 leukotriene A4 hydrolase 抑制剂，可用于癌症研究。

Bestatin hydrochloride (Ubenimex hydrochloride) 是CD13(Aminopeptidase N) APN 和leukotriene A4 hydrolase 抑制剂，可研究癌症。

SC-57461A 是一种口服有活力的非肽类白三烯 A4 (LTA4) 水解酶选择性抑制剂，它能够抑制重组人 (IC50: 2.5 nM) 、小鼠 (IC50: 3 nM) 和小鼠LTA4水解酶 (IC50: 23 nM) 。

Matlystatin A is an inhibitor of aminopeptidase. It shows multiple inhibitory activities against both aminopeptidase N and matrix metalloproteinases.

Phebestin is an aminopeptidase N inhibitor, produced by Streptomyces sp. MJ716-m3.

RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase.

Ebelactone A（依贝内酯A）是一种来自Streptomyces sp.的霉菌酸β-内酯（mycolic acid β-lactone），是有效的酯酶（esterase）抑制剂，能够抑制酯酶、脂肪酶、N-甲酰甲硫氨酸氨肽酶活性，常用作低毒性的抗生素。

APN AKT-IN-1 is a potent dual inhibitor of aminopeptidase N (APN) and protein kinase B (AKT), exhibiting IC50 values of 0.21 μM and 0.27 μM for APN and AKT inhibition, respectively. This compound effectively suppresses the phosphorylation of glycogen synthase kinase 3 beta (GSK3β), which serves as an intracellular substrate of AKT [1].

Bestatin trifluoroacetate (Ubenimex trifluoroacetate) 是一种 CD13 (Aminopeptidase N) APN 和 leukotriene A4 hydrolase 抑制剂，经常用于研究癌症。

NGR peptide Trifluoroacetate containing the asparagine-glycine-arginine (NGR) motif is recognized by CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in tumor neovasculature.