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| Cat. No. | Product Name | ||
|---|---|---|---|
| L1710 | 抗COVID-19化合物库 | 1160 compounds | |
| 1160 种对SARS-CoV-2有抑制作用或潜在抑制作用的化合物集合，可用于高通量和高内涵筛选； | |||
| Cat. No. | Product Name | Target | Signaling Pathways |
|---|---|---|---|
| T12839 | SARS-CoV-IN-3 | Others | Others |
| SARS-CoV-IN-3 is an effective SARS-CoV replication inhibitor. | |||
| T63679 | SARS-CoV-2 3CLpro-IN-3 | ||
| SARS-CoV-2 3CLpro-IN-3 是 SARS CoV-2 3CLpro 抑制剂，表现出抗病毒（antiviral）、抗细菌（antibacterial）、抗真菌（antifungal）效果。 | |||
| T62375 | SARS-CoV-2 nsp13-IN-3 | ||
| SARS-CoV-2 nsp13-IN-3 (Compound C3) 是一种 SARS-CoV-2 非结构蛋白 13（nsp13）小分子抑制剂，能够作用于 nsp13 ssDNA+ATPase (IC50: 32 μM)。 | |||
| T8498 |
EIDD-1931
Beta-d-N4-hydroxycytidine |
HCV Protease; SARS-CoV; Topoisomerase; Virus Protease | DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome |
| EiDD1931 是一种核苷类抗病毒试剂 ，可抑制丙型肝炎病毒、基孔肯亚病毒和委内瑞拉马脑炎病毒的复制活性。 | |||
| T60686 | SARS-CoV-2 Mpro-IN-1 | ||
| SARS-CoV-2 Mpro-IN-1 (化合物 16b-3) 是SARS-CoV-2主要蛋白酶 (Mpro) 的选择性不可逆抑制剂（IC50 = 116 nM）。 | |||
| T72451 | SARS-CoV-2 Mpro-IN-6 | ||
| SARS-CoV-2 Mpro-IN-6 是一种共价、不可逆和选择性的SARS-CoV-2 Mpro 抑制剂，IC50为 0.18 μM。SARS-CoV-2 Mpro-IN-6 不抑制人组织蛋白酶 B、F、K 和 L，以及半胱天冬酶 3。 | |||
| T63694 | SARS-CoV-2-IN-33 | ||
| SARS-CoV-2-IN-33 是 COVID-19 抑制剂。ARS-CoV-2-IN-3 对 COVID-19 主要蛋白酶 (Mpro) (PDB ID：6LU7) 表现出较好的结合亲和力 (-8.0 Kcal/mole)。SARS-CoV-2-IN-33 对癌细胞表现出较好的抗增殖效果。SSARS-CoV-2-IN-33 能够用于研究癌症和 COVID-19。 | |||
| T62829 | SARS-CoV-2 nsp14-IN-1 | ||
| SARS-CoV-2 nsp14-IN-1 (Compound 3) 是一种典型的 SARS-CoV-2Nsp14 Mtase 双底物抑制剂 (IC50: 0.061 μM)。SARS-CoV-2 nsp14-IN-1 对人类甲基转移酶表现出良好的选择性，可拮抗 10 种人甲基转移酶（如组蛋白赖氨酸、蛋白精氨酸、DNA 和 RNA 等）。 | |||
| T38174 | Mpro inhibitor N3 hemihydrate | ||
| Mpro inhibitor N3 hemihydrate is a potent inhibitor of SARS-CoV-2 Mpro with an EC50 of 16.77 μM for SARS-CoV-2. Mpro inhibitor N3 hemihydrate specifically inhibits Mpro from multiple coronaviruses, including SARS-CoV and MERS-CoV. Mpro inhibitor N3 hemihydrate displays inhibition against HCoV-229E, FIPV, and MHV-A59 with individual IC50 of 4.0 μM, 8.8 μM, and 2.7 μM, respectively[1][2]. Mpro inhibitor N3 hemihydrate (0-0.64 μM) is able to penetrate cells to inhibit the replication of IBV viruses... | |||
| T73963 | Hydroxychloroquine Impurity E | ||
| Hydroxychloroquine Impurity E 是 Hydroxychloroquine 的杂质。Hydroxychloroquine 是一种合成的抗疟疾剂，也可以抑制 Toll 样受体 7/9 (TLR7/9) 信号传导。Hydroxychloroquine 有效抑制SARS-CoV-2感染。 | |||
| T69035 | Camostat free base | ||
| Camostat, also known as FOY 305, is a serine protease inhibitor. Camostat is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease or pancreatitis. It is an inhibitor of the enzyme transmembrane protease, serine 2 (TMPRSS2). Inhibition of TMPRSS2 partially blocked infection by SARS-CoV and Human coronavirus NL63 in HeLa cell cultures. In vitro study showed that camostat significantly reduces... | |||
| T63760 | 3CPLro-IN-2 | ||
| 3CPLro-IN-2 是有效的、口服具有活力的 SARS-CoV-2 3CLpro 抑制剂 (IC50: 1.55 μM, Ki: 6.09 μM)。3-糜蛋白酶样半胱氨酸蛋白酶 (3CLpro) 是病毒复制中不可或缺的蛋白质，是有潜力的对抗 COVID-19 的药物靶点。 | |||
| T73964 | Hydroxychloroquine Impurity F | ||
| Hydroxychloroquine Impurity F 是 Hydroxychloroquine 的杂质。Hydroxychloroquine 是一种合成的抗疟疾剂，也可以抑制 Toll 样受体 7/9 (TLR7/9) 信号传导。Hydroxychloroquine 有效抑制SARS-CoV-2感染。 | |||
| T62479 | 3CPLro-IN-1 | ||
| 3CPLro-IN-1 (compound A17) 是一种有效的、口服具有活力的 SARS-CoV-2 3CLpro 抑制剂 (IC50: 5.65 μM)。3-糜蛋白酶样半胱氨酸蛋白酶 (3CLpro) 是一种病毒复制中不可或缺的蛋白质，是一种有吸引力的、对抗 COVID-19 的药物靶点。 | |||
| T73973 | Imatinib Impurity E | ||
| Imatinib Impurity E 是 Imatinib 的杂质。Imatinib 是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL，v-Abl，PDGFR，c-kit 激酶活性。Imatinib (STI571) 靠近 ATP 结合位点结合，将其锁定在封闭或自我抑制的构象中，因此半竞争性抑制蛋白质的酶活性。Imatinib 还抑制 SARS-CoV 和MERS-CoV。 | |||
| T74583 | Desmethylazelastine | ||
| Desmethylazelastine 是 Azelastine 通过细胞色素 P450 酶系统氧化代谢的主要活性代谢物，其蛋白结合率为 97%，消除半衰期为 54 小时。Azelastine 是一种具有口服活性、选择性和高亲和力的组胺H1受体拮抗剂。Azelastine 可用于过敏性鼻炎、哮喘、糖尿病高脂血症以及 SARS-CoV-2 的研究。 | |||
| T7911 | Arbidol | ||
| Umifenovir 是一种有效的口服活性广谱抗病毒药物，对许多包膜病毒和非包膜病毒具有活性。Umifenovir 既能抑制病毒繁殖又能调节炎性细胞因子的表达，可用作抗流感病毒剂 (anti-influenza virus)，并具有抗炎活性。Umifenovir 有效抑制病毒与宿主细胞的融合。 Umifenovir 是体外有效的 SARS-CoV-2的抑制剂。 | |||
| T73341 |
Quipazine
2-(1-哌嗪基)喹啉 |
||
| Quipazine 是一种5-HT 激动剂，取代大鼠内皮层中 5-HT3R 的 [3H]GR65630 的Ki 值为 1.4 nM。Quipazine 对SARS-CoV-2具有抗病毒活性，EC50值为 31.64 μM。Quipazine 在外周模型中表现为 5-HT3R 的激动剂，可用于神经疾病研究。 | |||
| T36762 | KW-8232 | ||
| KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2[1]. KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE2 in mouse osteoblastic cells[1].KW-8232 possesses anti-viral activity against SARS-CoV-2 (EC50 ~1.2 μM )[2]. KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary ca... | |||
| T73336 |
Ketotifen
酮替芬 ; HC 20-511 |
||
| Ketotifen (HC 20-511) 是一种具有口服活性的第二代非竞争性组胺 1 (H1) 受体阻滞剂和肥大细胞稳定剂。Ketotifen 可在体外阻断 6-磷酸葡萄糖酸脱氢酶 (6-PGD)。Ketotifen 还对 SARS-CoV-2和流感病毒 (Influenza virus) 具有抗病毒活性。Ketotifen 可用于自身免疫性脑脊髓炎 (EAE) 和预防哮喘发作的研究。 | |||
| T38297 |
Ribavirin-13C5
Ribavirin-13C5 |
||
| Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro... | |||
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