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Targets Recommended: Protease-activated Receptor

24

抑制剂 & 化合物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T38836L	Protease-Activated Receptor-1, PAR-1 Agonist acetate	Protease-activated Receptor	GPCR/G Protein
	Protease-Activated Receptor-1, PAR-1 Agonist acetate 是一种选择性蛋白酶激活受体 1 (PAR-1) 激动剂肽。它对应于 PAR1 栓系配体，可以选择性地模拟凝血酶通过该受体的作用。
T12870	SCH79797 dihydrochloride	Apoptosis; Others; Protease-activated Receptor	Apoptosis; GPCR/G Protein; Others
	SCH79797 dihydrochloride 是一种有效的特异性蛋白酶激活受体 1 (PAR1) 拮抗剂，IC50 为 70 nM，Ki 为 35 nM。SCH79797 dihydrochloride 具有抗增殖和促凋亡作用。
T1893	Parmodulin 2 ML 161	Protease-activated Receptor	GPCR/G Protein
	Parmodulin 2 (ML 161) 是一种蛋白酶激活受体 1(PAR1) 变构抑制剂，IC50为 0.26 μM。它是蛋白酶激活受体 1 (PAR1) 介导的血小板活化的抑制剂，可以抑制体外血小板聚集和体内血小板血栓形成。
T38836	Protease-Activated Receptor-1, PAR-1 Agonist
	Protease-Activated Receptor-1 (PAR-1) Agonist, a selective peptide, activates the PAR-1 receptor by mimicking the specific actions of thrombin. It corresponds to the PAR1 tethered ligand, facilitating selective activation of this receptor.
T7625	TRAP-6 PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA)	Protease-activated Receptor	GPCR/G Protein
	TRAP-6 (Thrombin Receptor Activator Peptide 6) 是一种多肽片段，是选择性的蛋白酶激活受体 1 (PAR1) 激动剂，通过凝血酶受体激活人血小板。
T36288	Protease-Activated Receptor-1, PAR-1 Agonist TFA
	Protease-Activated Receptor-1 (PAR-1) Agonist TFA is a selective peptide that acts as an agonist for the proteinase-activated receptor-1 (PAR-1). Corresponding to the tethered ligand of PAR-1, this compound mimics the actions of thrombin through the PAR-1 receptor[1][2].
T7573L	TFLLR-NH2 2TFA(197794-83-5(free base))	Protease-activated Receptor	GPCR/G Protein
	TFLLR-NH2 2TFA(197794-83-5(free base)) 是 PAR1 (EC50 :1.9 μM) 的激动剂。
T3098	Vorapaxar sulfate SCH 530348 sulfate,Zontivity,vorapaxar monosulfate,沃拉帕沙	Protease-activated Receptor	GPCR/G Protein
	Vorapaxar sulfate (Zontivity) 是一种选择性、口服活性和竞争性的凝血酶受体蛋白酶激活受体(PAR-1)拮抗剂，Ki 值为 8.1 nM。它剂量依赖性抑制凝血酶受体激活肽 (TRAP) 诱导的血小板聚集，是抗血小板药物。
T7573	TFLLR-NH2 TFLLR-NH2(2TFA)	Protease-activated Receptor	GPCR/G Protein
	TFLLR-NH2 是选择性的一种PAR1激动剂，EC50值为1.9 μM。
T23282	RWJ-56110	Others	Others
	protease-activated receptor-1 (PAR1) antagonist
T7013	Vorapaxar SCH 530348,MK-5348,沃拉帕沙	Protease-activated Receptor	GPCR/G Protein
	Vorapaxar (MK-5348) 是抗血小板药物，是一种选择性、口服活性和竞争性的凝血酶受体蛋白酶激活受体(PAR-1)拮抗剂，Ki 值为 8.1 nM。它靠剂量依赖性抑制凝血酶受体激活肽 (TRAP) 诱导的血小板聚集。
T71109	BAY-386
	BAY-386 is a PAR1 receptor inhibitor which suppresses activation of thrombin and platelet activity.
T23208	Q94 hydrochloride	Others	Others
	PAR1 negative allosteric modulator
T28734	SCH79797 SCH 79797,SCH-79797
	SCH-79797 is a potent and selective PAR1 antagonist.
T28477	PZ-128 PZ 128
	PZ-128, a PAR1 antagonist, is used potentially for the treatment of thrombosis.
TP1334	TFLLR-NH2(TFA)
	TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. EC50: 1.9 μM (PAR1)
T78545	FLLRN TRAP-6 (2-6)
	FLLRN是一种具有生物活性的(PAR1特异性拮抗肽)。
T35867	TRAP-6 Peptide (trifluoroacetate salt)
	TRAP-6 peptide is a hexapeptide corresponding to residues 42-47 of protease-activated receptor 1 (PAR1). It acts as an agonist of PAR1, inducing platelet aggregation in human platelet-rich plasma ex vivo (EC50 = 0.8 μM). TRAP-6 (0.3 and 0.6 mg/kg) has a triphasic effect on mean arterial blood pressure (MAP) in anesthetized rats with a short decrease, an increase, and then a longer decrease in MAP following intravenous administration.
T26744	BAY-598 R-isomer BAY598 R-isomer,BAY 598 R-isomer
	BAY-598 R-异构体是BAY589的R-异构体，它可用作参考化合物。它是是赖氨酸N-甲基转移酶（SMYD2）的抑制剂，对SMYD2比蛋白酶激活的受体1（PAR1）具有选择性。
T23237	RLLFT-NH2	Others	Others
	TFLLR-NH2, reversed amino acid sequence control peptide, is a PAR1 selective agonist that significantly increases the nociceptive threshold.
TP1965	Parstatin(human) Parstatin (human)
	Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 3 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apop
TP1966	Parstatin(mouse) Parstatin (mouse)
	Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 20 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apo
T80111	TRAP-5 amide
	TRAP-5 amide为蛋白酶激活受体1（PAR1）特异性的激动剂肽。
T36717	RWJ-56110 dihydrochloride
	RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 . RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell ap...

化合物

Protease-Activated Receptor-1, PAR-1 Agonist acetate

Cat.No: T38836L

Target: Protease-activated Receptor

SCH79797 dihydrochloride

Cat.No: T12870

Target: Apoptosis, Others, Protease-activated Receptor

Cat.No: T1893

Synonym: ML 161

Target: Protease-activated Receptor

Protease-Activated Receptor-1, PAR-1 Agonist

Cat.No: T38836

Cat.No: T7625

Synonym: PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA)

Target: Protease-activated Receptor

Protease-Activated Receptor-1, PAR-1 Agonist TFA

Cat.No: T36288

TFLLR-NH2 2TFA(197794-83-5(free base))

Cat.No: T7573L

Target: Protease-activated Receptor

Vorapaxar sulfate

Cat.No: T3098

Synonym: SCH 530348 sulfate,Zontivity,vorapaxar monosulfate,沃拉帕沙

Target: Protease-activated Receptor

Cat.No: T7573

Synonym: TFLLR-NH2(2TFA)

Target: Protease-activated Receptor

Cat.No: T23282

Target: Others

Cat.No: T7013

Synonym: SCH 530348,MK-5348,沃拉帕沙

Target: Protease-activated Receptor

Cat.No: T71109

Q94 hydrochloride

Cat.No: T23208

Target: Others

Cat.No: T28734

Synonym: SCH 79797,SCH-79797

Cat.No: T28477

Synonym: PZ 128

Cat.No: TP1334

Cat.No: T78545

Synonym: TRAP-6 (2-6)

TRAP-6 Peptide (trifluoroacetate salt)

Cat.No: T35867

BAY-598 R-isomer

Cat.No: T26744

Synonym: BAY598 R-isomer,BAY 598 R-isomer

Cat.No: T23237

Target: Others

Parstatin(human)

Cat.No: TP1965

Synonym: Parstatin (human)

Parstatin(mouse)

Cat.No: TP1966

Synonym: Parstatin (mouse)

Cat.No: T80111

RWJ-56110 dihydrochloride

Cat.No: T36717

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05025	Thrombin Receptor Protein, Human, Recombinant (His) TR,PAR1,HTR,coagulation factor II (thrombi...	Human	HEK293 Cells
	Thrombin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 10.2 kDa and the accession number is A0A024RAP7.

重组蛋白

Thrombin Receptor Protein, Human, Recombinant (His)

Cat.No: TMPY-05025

Species: Human

Expression System: HEK293 Cells

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