11
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14342 |
Atorvastatin lactone
|
HMG-CoA Reductase | Metabolism |
Atorvastatin lactone 是一种 Atorvastatin 的前药。其中 Atorvastatin 是口服具有活力的 3- 羟基 -3- 甲基戊二酰辅酶 A 还原酶抑制剂。 | |||
T28009 |
ME-3221
ME3221 |
||
Apomine is an inhibitor of HMG-CoA-reductase. It promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo. Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-meth | |||
T26644 |
Apomine
SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A |
HMG-CoA Reductase | Metabolism |
Apomine (SR-9223i) 是一种 HMG-CoA-还原酶抑制剂,可在体外促进骨髓瘤细胞的凋亡,并与体内骨髓瘤的调节有关。 Apomine 加速 3-羟基-3-甲基戊二酰-CoA 还原酶的降解并刺激低密度脂蛋白受体活性。 Apomine 通过下调 3-羟基-3-甲基戊二酰-CoA 还原酶来增强洛伐他汀对骨髓瘤细胞的抗肿瘤作用。 | |||
T10132 |
(3S,5S)-Pitavastatin calcium
|
Others | Others |
(3S,5S)-Pitavastatin calcium is the 3-epimer of Pitavastatin which is a potent HMG-CoA reductase inhibitor. | |||
T72155 |
(Rac)-3′-Hydroxy simvastatin
|
||
(Rac)-3′-Hydroxy simvastatin 是一种 Simvastatin 代谢物。Simvastatin 是一种竞争性的 HMG-CoA 还原酶抑制剂,Ki 值为 0.2 nM。 | |||
T10120 |
3-Oxo Atorvastatin
|
Others | Others |
3-Oxo Atorvastatin is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids. | |||
T12283 |
O-Methyl Atorvastatin hemicalcium
|
Others | Others |
O-Methyl Atorvastatin is an impurity of Atorvastatin that is an orally active inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, has the ability to effectively decrease blood lipids. | |||
T10399 |
Atorvastatin 3-Deoxyhept-2E-Enoic Acid
(2E)-2,3-Dehydroxy Atorvastatin |
Others | Others |
Atorvastatin 3-Deoxyhept-2E-Enoic Acid is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids. | |||
T36827 |
Acetoacetyl Coenzyme A (sodium salt hydrate)
Acetoacetyl-CoA |
||
Acetoacetyl-coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.[1],[2] It is reversibly converted to acetyl-CoA by acetoacetyl-CoA thiolase in the mitochondria. Acetoacetyl-CoA thiolase (T2) deficiency results in a build-up of ketone bodies leading to intermittent ketoacidosis.[3],[4] Acetoacetyl-CoA is also an intermediate in the microbial biosynthesis of polyhydroxybutyrate.[5] | |||
T36863 |
Geranylgeranyl Pyrophosphate (ammonium salt)
Geranylgeranyl Pyrophosphate (ammonium salt),GGPP |
||
Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.[1] It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.[2] This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug disco... | |||
T35718 |
N-desmethyl Rosuvastatin (sodium salt hydrate)
|
||
N-desmethyl Rosuvastatin is an active metabolite of the HMG-CoA reductase inhibitor rosuvastatin .1,2N-desmethyl Rosuvastatin is formed when rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) isoform CYP2C9 and to a lesser extent by CYP2C19 and CYP3A4.1 1.Macwan, J.S., Ionita, I.A., and Akhlaghi, F.A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tand... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1664 |
Meglutol
Dicrotalic acid,3-Hydroxy-3-methylglutaric acid,美格鲁托 |
Endogenous Metabolite; HMG-CoA Reductase; Autophagy | Autophagy; Metabolism |
Meglutol (3-Hydroxy-3-methylglutaric acid) 是一种抗血脂剂,可降低胆固醇、甘油三酯、血清 β-脂蛋白和磷脂。它抑制胆固醇生物合成中的限速酶羟甲基戊二酰辅酶 A 还原酶的活性。 | |||
T35400 |
β-Muricholic Acid
β-MCA,5β-Cholanic Acid-3α,6β,7β-triol,β-Muricholic Acid |
||
β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.[4] |