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Oxacillin sodium salt

Name: Oxacillin sodium salt
Brand: TargetMol
SKU: T0985
Price: 153 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 苯唑西林, Oxacillin sodium, Oxabel sodium salt

货号 T0985Cas号 1173-88-2 一键复制产品信息纯度: 99.93%

很棒

Oxacillin sodium salt (Oxabel) 是一种青霉素类的窄谱β-内酰胺抗生素，用于耐药葡萄球菌感染。

Oxacillin sodium salt

一键复制产品信息

很棒

纯度: 99.93%

货号 T0985Cas号 1173-88-2

别名 苯唑西林, Oxacillin sodium, Oxabel sodium salt

Oxacillin sodium salt (Oxabel) 是一种青霉素类的窄谱β-内酰胺抗生素，用于耐药葡萄球菌感染。

规格	价格	库存
50 mg	¥ 231	现货
100 mg	¥ 413	现货
200 mg	¥ 588	现货
500 mg	¥ 980	现货
1 mL x 10 mM (in DMSO)	¥ 153	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.93%

颜色: 白色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Oxacillin sodium salt AI Summary

Oxacillin sodium salt exhibits a broad range of bioactivities, including significant antibacterial and antiviral properties. It demonstrates potent activity as an inhibitor of beta-lactamase in Enterobacter aerogenes, with a high relative inhibition value of 5000.0 compared to oxacillin sulfoxide, and shows efficacy against methicillin-resistant Staphylococcus aureus (MRSA) with MIC values as low as 0.25 ug/mL. Additionally, MIC values against other bacterial strains vary widely, from highly potent (≤ 0.39 ug/mL against Staphylococcus aureus) to less effective (> 128.0 ug/mL against certain penicillin-resistant strains). In pharmacokinetic studies, the compound reaches a concentration of 41.1 ug/mL in rat blood within 3 minutes and displays varied absorption rates in rabbit blood (15.3 ug/mL after 5 minutes and 9.1 ug/mL after 10 minutes). It also possesses a calculated lipophilicity with a Log k value of 1.868. In terms of antiviral activity, Oxacillin sodium salt shows inhibition of SARS-CoV-2 induced cytotoxicity in several cell lines, including VERO-6 and Caco-2 cells, although the inhibition rates are relatively low (0.08% and 3.58% respectively, at 10 uM). Furthermore, it inhibits the SARS-CoV-2 3CL-Pro protease with an inhibition percentage of 33.68% at 20µM. Oxacillin sodium salt also impacts various biochemical pathways and targets, such as enhancing SMN2 splice variant expression with a potency of 501.2 nM, and inhibiting Aldehyde Dehydrogenase 1 (ALDH1A1) and AmpC Beta-Lactamase with potencies of 44668.4 nM and 5623.4 nM respectively. It exhibits a potent inhibitory effect on sodium fluorescein uptake in OATP1B1-transfected and OATP1B3-transfected CHO cells, with inhibition rates of 76.67% and 90.07% at 10 uM. Lastly, Oxacillin sodium salt shows low inhibitory effects on human BSEP, MRP2, MRP3, and MRP4, with IC50 values greater than 133,000.0 nM, and demonstrates minimal impact on cell viability in Vero E6 cells infected with SARS-CoV-2. It also exhibits differential inhibition of human HDAC6 activity, with various effects depending on the peptide substrates used in enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Oxacillin sodium salt (Oxabel) is an antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.
别名	苯唑西林, Oxacillin sodium, Oxabel sodium salt

化学信息

分子量	423.43
分子式	C₁₉H₁₈N₃NaO₅S
CAS No.	1173-88-2
Smiles	[Na+].Cc1onc(c1C(=O)N[C@H]1[C@H]2SC(C)(C)[C@@H](N2C1=O)C([O-])=O)-c1ccccc1
密度	1.49g/cm3

储存&溶解度

存储

溶解度信息

DMSO: 128 mg/mL (302.29 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.81 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3617 mL	11.8083 mL	23.6167 mL	118.0833 mL
5 mM	0.4723 mL	2.3617 mL	4.7233 mL	23.6167 mL
10 mM	0.2362 mL	1.1808 mL	2.3617 mL	11.8083 mL
20 mM	0.1181 mL	0.5904 mL	1.1808 mL	5.9042 mL
50 mM	0.0472 mL	0.2362 mL	0.4723 mL	2.3617 mL
100 mM	0.0236 mL	0.1181 mL	0.2362 mL	1.1808 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Oxacillin sodium salt Oxacillin Oxabel Bacterial antibiotic

Oxacillin sodium salt

Oxacillin sodium salt