Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) 具有用于1型糖尿病的研究潜力,它是 12/15 脂氧合酶的有效抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 598 | 5日内发货 | ||
5 mg | ¥ 987 | 6-8周 | ||
10 mg | ¥ 1,550 | 6-8周 | ||
100 mg | ¥ 6,990 | 6-8周 |
产品描述 | Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) has the potential in the type 1 diabetes mellitus research that is a potent inhibitor of 12/15-Lipoxygenases (LO) [1]. |
体外活性 | High glucose or 12(S)-HETE remarkably increased transendothelial dextran transport, and in combination it was increased further. Addition of the 12/15-LO inhibitor, CDC, partially suppressed dextran transport [1]. |
体内活性 | The high glucose and 12(S)-hydroxyeicosatetraenoic acid (HETE) could alter vascular endothelial (VE)-cadherin and β‐catenin phosphorylation levels, but did not alter total protein expression. However, the 12/15-LO inhibitor, Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), antagonized the effect of high glucose on protein phosphorylation to mitigate destruction of the endothelial cell barrier, and the mouse diabetes mellitus model further confirmed these conclusions [1]. |
分子量 | 321.33 |
分子式 | C19H15NO4 |
CAS No. | 132465-11-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate 132465-11-3 Others Inhibitor inhibitor inhibit