store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CP-66948 是一种有效的 histamine H2 受体拮抗剂,对胃酸分泌有抑制作用,可用于保护胃黏膜和肠粘膜。
产品描述 | CP-66948 is a potent histamine H2 receptor antagonist with inhibitory effect on gastric acid secretion and can be used to protect gastric and intestinal mucosa. |
体内活性 | CP-66,948 exhibits an affinity for the guinea pig atria histamine H2-receptor that is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED50 value for the inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally. In histamine or pentagastrin-stimulated Heidenhain pouch dogs, the antisecretory ED50 values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also demonstrates inhibition of ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration, with ED50 values of 12 mg/kg per os and 6 mg/kg subcutaneously[1]. |
分子量 | 292.4 |
分子式 | C13H20N6S |
CAS No. | 101189-47-3 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CP-66948 101189-47-3 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor CP 66948 CP66948 Inhibitor inhibitor inhibit