(R)-(+)-Dimethindene maleate possesses membrane-stabilising effect [1].

(R)-(+)-Dimethindene maleate (10 mL/kg; i.g.; once) shows antihistaminic activity with an ED 50 of 2.73 mg/kg in pigs [1]. Animal Model: Male guinea-pigs [1] Dosage: 10 mL/kg Administration: Oral gavage, once Result: The ED 50 -value for a protection from a fatal histamine shock was calculated as 2.73 mg/kg when administered orally 1 h before the injection of histamine. The calculated oral anti-anaphylactic ED 50 -value was found to be >31.6mg/kg. The oral LD 50 -values was found to be 988 mg/kg.