| Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
|---|---|---|---|---|
| T9948 | NecroX-7
化合物 NecroX-7
|
1120332-55-9 | 98% |
|
| NecroX-7 是一种有效的自由基清除剂和HMGB1(高迁移率族蛋白 1) 抑制剂。NecroX-7 可以作为对乙酰氨基酚毒性的解毒剂。NecroX-7 通过抑制缺血/再灌注损伤中 HMGB1 的释放发挥保护作用。NecroX-7 抑制 HMGB1 诱导的TNF和IL-6的释放，以及TLR-4和晚期糖基化终产物受体的表... | ||||
| TN3112 | 5-Heneicosylresorcinol
5-二十一烷基间苯二酚
|
70110-59-7 | 98% |
|
| 5-Heneicosylresorcinol 对 RBL-2H3 细胞中 β-己糖胺酶的释放具有抑制作用，它还可以防止 3T3-L1 细胞中甘油三酯的积累。它对红线虫、秀丽隐杆线虫和松材线虫具有杀线虫活性，ED50 值分别为 80、30 和 180 ug/mL。 | ||||
| T8107 | GLX351322
化合物GLX351322
|
835598-94-2 | 99.7% |
|
| GLX351322 抑制 NADPH 氧化酶 4 (Nox4) 。在 NOX4 过表达的细胞中，抑制过氧化氢的产生，IC50值为 5 μM。 | ||||
| T0679 | Ketoconazole
酮康唑
|
65277-42-1 | 99.62% |
|
| Ketoconazole 是一种咪唑类抗真菌剂，也是一种 CYP3A4 抑制剂。 | ||||
| T10353 | APX-115 free base
化合物APX-115 free base
|
1270084-92-8 | 99.03% |
|
| APX-115 free base 是口服具有活性的、非选择性的Nox抑制剂，对Nox1，Nox2和Nox4的Ki分别为 1.08 μM，0.57 μM 和 0.63 μM。它能够有效预防糖尿病小鼠的肾损伤。 | ||||
| T8408 | GKT136901
化合物GKT136901
|
955272-06-7 | 98.29% |
|
| GKT136901 是选择性的和具有口服活性的NADPH氧化酶NOX-1/4抑制剂，Ki分别为 160 和 165 nM。它具有抗炎症活性。它也是一种选择性和直接的过氧亚硝酸清除剂。它可用于糖尿病肾病，中风和神经退行性疾病的研究。 | ||||
| TN2126 | Quercetin-3-O-glucose-6''-acetate
槲皮素-3-O-葡萄糖苷-6′′-乙酯
|
54542-51-7 | 97.48% |
|
| Quercetin-3-O-glucose-6''-acetate 是 NADPH 氧化酶的抑制剂。 Quercetin-3-O-glucose-6''-acetate 具有抗氧化活性。 | ||||
| TP1886L1 | NoxA1ds acetate(1435893-78-9 free base)
化合物NoxA1ds acetate
|
TP1886L1 | 96.92% |
|
| NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxida... | ||||
| T6099 | Setanaxib
化合物GKT137831
|
1218942-37-0 | 96.72% |
|
| GKT137831是一种有效的特异性双重 NADPH 氧化酶 (NOX1/4) 抑制剂，Ki分别为140和110nM。 | ||||
| T22990 | ML-090
化合物ML-090
|
531-46-4 | 98% |
|
| ML-090 是 NOX1 特异性抑制剂 (IC50 = 90 nM)，对 NOX1 的特异性高于 NOX2、NOX3、NOX4（所有 IC50 > 10 μM）100倍。 | ||||
| TJS1779 | Protosappanin A
原苏木素A
|
102036-28-2 | 98% |
|
| Protosappanin A是从苏木中分离得到的免疫抑制成分和主要联苯化合物，通过下调JAK2和STAT3的磷酸化，抑制JAK2/STAT3依赖的炎症通路。 | ||||
| TN4800 | Pisatin
化合物 TN4800
|
20186-22-5 | 98% |
|
| Pisatin is an isoflavonoid phytoalexin synthesized by pea (Pisum sativum L.). | ||||
| TMA1570 | Sappanone A
化合物 TMA1570
|
102067-84-5 | 98% |
|
| Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ... | ||||
| TN5278 | Zederone
化合物 TN5278
|
7727-79-9 | 98% |
|
| Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads t... | ||||
| TN3300 | 8alpha-Tigloyloxyhirsutinolide 13-O-acetate
化合物 TN3300
|
83182-58-5 | 98% |
|
| 8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has ... | ||||
| TN1542 | Cycloheterophyllin
异叶波罗蜜环黄酮素
|
36545-53-6 | 98% |
|
| Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be u... | ||||
| T25952 | Phox-I2
化合物Phox-I2
|
353495-22-4 | 98% |
|
| Phox-I2 is an NOX2-specific inhibitor. Phox-I2 reverts ROS-accumulation and leads to refusion of mitochondrial networks. | ||||
| TN1645 | Flavokawain C
2',4-二羟基-4',6'-二甲氧基查耳酮
|
56798-34-6 | 98% |
|
| Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle... | ||||
| TN5156 | Totaradiol
化合物 TN5156
|
3772-56-3 | 98% |
|
| Totaradiol shows antioxidant activity, it can inhibit linoleic acid autoxidation but not generation of superoxide anion. Totaradiol exhibits cytotoxic activity a... | ||||
| TN2036 | Paeonilactone B
(3AR,6S,7AR)-四氢-6-羟基-6-甲基-3-亚甲基-2,5(3H,4H)-苯并呋喃二酮
|
98751-78-1 | 98% |
|
| Paeonilactone B is a natural product from Paeonia albiflora. | ||||
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