MELK

Maternal embryonic leucine zipper kinase (MELK) is an enzyme that in humans is encoded by the MELK gene. MELK is a serine/threonine kinase belonging to the family of AMPK/Snf1 protein kinases. MELK was first identified present as maternal mRNA in mouse embryos. MELK expression is elevated in a number of cancers and is an active research target for pharmacological inhibition.

Cat. No.	Product Name	CAS No.	Purity
T11732	JTV-519 hemifumarate 化合物 T11732	1435938-25-2	98%
T11732	JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a p...
T35342	MELK-8a Dihydrochloride MELK-8a Dihydrochloride		98%
T35342	MELK-8a Dihydrochloride 是一种新型的母体胚胎亮氨酸拉链激酶（MELK）抑制剂，其 IC50值为2 nM。
T21559	OTSSP167 hydrochloride OTSSP 167 盐酸盐	1431698-10-0	98%
T21559	OTSSP167 hydrochloride 是一种高效的，ATP 竞争性的MELK 抑制剂，其 IC50=0.41 nM。
T11996	MELK-8a hydrochloride 化合物MELK-8a hydrochloride	2096992-20-8	98%
T11996	MELK-8a hydrochloride 是一种有效的母体胚胎亮氨酸拉链激酶抑制剂，IC50 为 2 nM。
T11997	MELK-IN-1 尼达尼布杂质L	2095596-44-2	98%
T11997	MELK-IN-1是一种母体胚胎亮氨酸拉链激酶的有效抑制剂，IC50=3 nM，Ki=0.39 nM。
T24152	HTH-01-091 化合物HTH-01-091	2000209-42-5	98%
T24152	HTH-01-091 是一种强效且选择性的 maternal embryonic leucine zipper kinase (MELK) 抑制剂（IC50 ：10.5 nM）。HTH-01-091 对PIM1/2/3、RIPK2、DYRK3、smMLCK 和 CLK2有抑制作用。HTH-01-091 可用于研究乳腺癌。...
T1759	OTSSP167 化合物OTSSP167	1431697-89-0	98%
T1759	OTSSP167 是一种高效的，ATP 竞争性的 MELK 抑制剂，其 IC50=0.41 nM。
T12237	NMS-P715 化合物NMS-P715	1202055-32-0	98%
T12237	NMS-P715 是一种 ATP 竞争性MPS1选择性抑制剂，IC50值为 182 nM。