ASK

Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion in response to an array of stresses such as oxidative stress, endoplasmic reticulum stress and calcium influx. ASK1 has been found to be involved in cancer, diabetes, rheumatoid arthritis, cardiovascular and neurodegenerative diseases.

Cat. No.	Product Name	CAS No.	Purity
T5190	GS-444217 化合物GS-444217	1262041-49-5	99.58%
T5190	GS-444217 是一种可口服的选择性 ATP 竞争性凋亡信号调节激酶 1 抑制剂，IC50为 2.87 nM。
T3350	Selonsertib 化合物Selonsertib	1448428-04-3	99.53%
T3350	Selonsertib 是一种选择性的，具有生物口服可利用的凋亡信号调节激酶1 抑制剂，pIC50为 8.3。它具有潜在的抗炎、抗肿瘤和抗纤维化活性。
T3101	NQDI-1 化合物NQDI1	175026-96-7	97.19%
T3101	NQDI-1 是一种凋亡信号调节激酶 1 抑制剂，Ki为 500 nM，IC50为 3 μM。
T33514	MSC 2032964A 化合物MSC 2032964A	1124381-43-6	100%
T33514	MSC 2032964A 是一种有效的选择性 ASK1 抑制剂 (IC50 = 93 nM)，具有口服生物利用度和脑渗透性。它在小鼠 EAE 模型中抑制神经炎症，并在培养的小鼠星形胶质细胞中阻断 LPS 诱导的 ASK1 和 p38 磷酸化。
T9377	ASK1-IN-2 化合物ASK1-IN-2	2541792-70-3
T9377	ASK1-IN-2 是一种口服有活性的凋亡信号调节激酶 1 抑制剂(IC50:32.8 nM)。它可用于研究溃疡性结肠炎。
T9697	ASK1-IN-1 化合物ASK1-IN-1	2411382-24-4	98%
T9697	ASK1-IN-1 是一种凋亡信号调节激酶 1（SK1）抑制剂，具有良好的效价 (细胞IC50=138 nM; BiochemicalIC50=21 nM)。ASK1-IN-1具有中枢神经系统渗透性。
T13099	TC ASK 10 化合物TC ASK 10	1005775-56-3	98%
T13099	TC ASK 10 是选择性的，口服有效的细胞凋亡信号调节激酶 1 抑制剂，IC50为 14 nM。它对其他代表性激酶的抑制活性低于 50％，除ASK2之外 (IC50为 0.51 μM)。
T67857	(Z)-4-(5-((5-(4-bromophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid 化合物T67857	1427538-26-8	98%
T67857	(Z)-4-(5-((5-(4-bromophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid是一种ASK1抑制剂，IC50 = 0.2 μM。
TN4635	Neoechinulin A 化合物 TN4635	51551-29-2	98%
TN4635	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the ...