taste receptor

Aspartame (SC-18862) 是一种二肽的甲酯，由苯丙氨酸 (50%)，天门冬氨酸 (40%) 和甲醇 (10%) 组成。它可用作合成的非营养性甜味剂。

Lactisole (na-PMP) 是葡萄糖感应受体的抑制剂。

Alitame (hydrate) (Standard) is the standard substance of Alitame (hydrate), and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Alitame hydrate is a non-nutritive sweetener that is 2000 times sweeter than sucrose. It is formed from aspartic acid, alanine & an amide.

Denatonium benzoate (THS-839) 是一种已知的最苦的化合物，可作为厌恶剂(苦味剂)，加入到工业酒精、防冻液、咬指甲癖预防、呼吸器面罩配合测试、动物驱虫剂、液体皂和洗发水中，防止不适当的摄取。

Neotame (HSDB 7965) 是阿斯巴甜的衍生物，是低热量、高效的人造甜味剂，非营养性甜味剂和增味剂，其甜度是糖的 7000-13,000 倍，可用于多种食品。

6-Methoxyflavanone（6-MeOF）是人重组GABA A受体GABA反应的正变构调节剂，具有抗焦虑活性和抗炎活性，可用于减轻顺铂诱导的神经性疼痛。

Adenosine 5'-succinate is a compound closely related to adenosine monophosphate (AMP) that demonstrates strong inhibitory properties against taste receptor activation of transducin caused by Denatonium benzoate.

GIV3727 是 hTAS2R 苦味受体的拮抗剂，能够抑制糖精与安赛蜜对 hTAS2R31 的活化作用，有效改善食品、饮料和药品的苦味特性。

Alitame hydrate is a non-nutritive sweetener that is 2000 times sweeter than sucrose. It is formed from aspartic acid, alanine & an amide.

Epiquinidine, a quinine analogue, can be used as the ggTas2r1 agonist. Epiquinidine activates ggTas2r1 at or beyond 10 μM.

S6821 is a TAS2R8 antagonist. S6821 was not found to be mutagenic or clastogenic in vitro, and did not induce micronuclei in bone marrow polychromatic erythrocytes in vivo.

Lysine-N,N-diacetic acid （BCML） 是一种高效性的苦味受体4 （TAS2R4 ）抑制剂，阻断对人 TAS2R4 介导的奎宁的反应。

TAS2R14 agonist-2 (compound 28.1) 作为选择性TAS2R14抑制剂，其EC50为72 nM。

TAS2R14 agonist为一种TAS2R14受体的部分激活分子，其EC50值确定为116.6±23.6 nM。

FEMA 4774 (S9632) 是 T1R2/T1R3 的正变构调节剂。 FEMA 4774 在感官评价测试中表现出明显增强蔗糖的甜度。

Dulcoside A 是从甜叶菊中分离得到的。 Dulcoside A 是一种甜味剂，具有抗氧化活性。

Perillartine (DL-Perillartine) 是甜味剂，能够激活味觉受体 1 型成员 2 。

P2X3 antagonist 34 是一种对P2X3同型三聚体受体具有高效性、选择性和口服活性的拮抗剂，其IC50值针对人类P2X3、大鼠P2X3及豚鼠P2X3分别为25 nM、92 nM和126 nM。相比之下，该化合物对人类、大鼠和豚鼠的P2X2/3异三聚体受体展现低活性。P2X3 antagonist 34 显著具有抗咳功效，同时不会影响味觉。

RO5166017 是一种具有口服活性、高效性和选择性的痕量胺相关受体 1（TAAR1）激动剂，可用于研究条件性味觉厌恶额神经障碍。

Lactisole free acid 作为一种选择性的甜味味觉受体拮抗剂,其作用机制主要是靶向T1R3亚基,一种关键的葡萄糖感应受体.该化合物能有效抑制小鼠胰岛葡萄糖诱导的胰岛素分泌.

Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite initially derived from Penicillium, exhibiting antibacterial (MICs = 125-1000 µg/ml) and antifungal activities (MICs = 8-64 µg/ml). It also demonstrates antioxidant properties by reducing the production of hydroxy radicals, as evidenced in an electron spin resonance (ESR) spectroscopy assay (IC50 = 1.8 µM). Additionally, Cyclo(L-Leu-L-Trp) has been identified as a bitter compound capable of quickly crossing rat taste cell membranes ex vivo at a 1 mM concentration. Furthermore, it acts as a melatonin receptor agonist in X. laevis melanophores, suppressing cAMP accumulation at a 20 µM concentration, with this effect being negated by the melatonin receptor antagonist luzindole.