positron emission tomography

HG-10-102-01 是富含亮氨酸重复激酶 2 和突变型G2019S 抑制剂，IC50分别为20.3 nM 和3.2 nM。

Benperidol (Anquil)是一种具有抗精神病和安定作用的丁酮类化合物，在阻断 D2 受体方面具有很好的疗效。Benperidol可用于正电子发射断层扫描(PET)测量体内 D(2)类多巴胺受体的结合情况。

DPA-714 是高亲和力的移位蛋白配体 (Ki=7 nM)，它结构中有一个氟原子，能够被氟 -18 进行标记，并可通过正电子发射断层成像进行活体成像。它可在各种神经炎症模型及脑肿瘤模型中成功评估炎症的特异性成像。

PK14105 has been evaluated biologically as a potential radioligand for positron emission tomography (PET) studies targeting peripheral benzodiazepine binding sites (PBBS) receptors. When administered to rats with unilaterally lesioned striata, PK14105 was observed to quickly cross the blood-brain barrier, displaying significant radioactivity retention in the lesioned striatum, in contrast to the unlesioned striatum or cerebellar vermis. Additionally, PK14105 has the capability to inhibit receptor ligands, calcium channel ligands, and co-transporters in all salivary glands.

Verubulin (MPC 6827) 是一种高效的微管阻断剂，具有细胞毒活性和潜在的抗癌活性，可破坏异种移植物中新形成的血管，可用于使用正电子发射断层扫描（PET）对微管（MT）进行成像。

DOTA-NHS-ester 是 affibody 分子的接头，应用于小动物 PET、SPECT 和 CT。 它可用于标记放射治疗剂或成像探针以检测肿瘤。

MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs). MK-6240 exhibits high specificity and selectivity for binding to NFTs.

T807 (AV-1451) 是新型的tau 正电子发射断层扫描示踪剂。

DOTA-NHS-ester (TFA) 是 affibody 分子的一种交联剂，适用于小型动物的正电子发射断层扫描 (PET)、单光子发射计算机断层扫描 (SPECT) 和 CT 扫描。此化合物主要用于标记放射性研究试剂和成像探针，以便于肿瘤的检测。

PARP1-IN-29, 一种口服活性的PARP-1抑制剂，其IC50为6.3 nM。经[18F]标记的PARP1-IN-29 可用于通过正电子发射断层扫描 (PET) 成像，特异性地靶向肿瘤中的PARP-1。此化合物广泛应用于肿瘤学和成像研究，尤其适用于检测癌症中PARP-1的活性。

MeS-IMPY在与来自阿尔茨海默病（AD）患者大脑或AD脑匀浆中提取的β-amyloid plaques结合时展现出较IMPY更高的亲和力（Ki分别为7.93和8.95 nM）。[11C]MeS-IMPY作为一种潜在的放射性配体，适用于正电子发射断层扫描（PET）成像，用于探测β-淀粉样斑块。

PXT-012253 作为一种专一针对mGluR4的正电子发射断层显像 (PET) 配体，能特异性地结合到该受体的变构位点。该化合物主要应用于研究帕金森病及左旋多巴诱导的运动障碍。

N-Methylspiroperidol 是一种 D2 受体拮抗剂。可将 N-Methylspiroperidol 标记为 [18F]N-Methylspiroperidol，通过 PET (正电子发射断层扫描) 研究其与 5-HT2C 受体的结合情况，以及多巴胺等神经递质对这些受体的竞争与影响。

Lissamine rhodamine B, a new Radiotracer, is used for Imaging Tumors by Positron Emission Tomography.

L-FMAC F-18 has potential diagnostic activity during positron emission tomography (PET) imaging. After phosphorylation by DCK, the 18F moiety can be visualized by PET imaging.

(18F)LBT 999 is a positron emission tomography (PET) tracer, used for the quantification of the dopamine transporter (DAT) in the healthy rat brain.

DCFBC F-18 is a radioconjugate containing a low molecular weight tracer, DCFBC, specific for prostate-specific membrane antigen (PSMA) and labeled with the positron-emitting isotope F 18 with potential prostate tumor imaging upon positron emission tomogra

GSK931145 is a positron emission tomography (PET) radioligand, it is suitable for quantifying glycine transporter (GlyT1) availability in the living brain.

LMI-1195 is a 18F-labeled ligand for the norepinephrine transporter. LMI-1195 is used for mapping cardiac nerve terminals in vivo using positron emission tomography (PET).

PSMA-11 (HBED-CC-PSMA)通过与前列腺特异性膜抗原(PSMA)的细胞外结构域结合来检测前列腺癌的复发和转移。PSMA-11常被用作正电子发射断层扫描(PET)中用作表达PSMA 的肿瘤的示踪剂，通过静脉注射镓Ga 68标记的PSMA-11，Glu-urea-Lys(Ahx)分子靶向并结合表达PSMA 的肿瘤细胞。内化后，PSMA 表达的肿瘤细胞可在PET 成像中被检测到。

Altanserin can binds to the 5-HT2A receptor. Labeled with the isotope fluorine-18 it is used as a radioligand in positron emission tomography (PET) studies of the brain.

Altanserin tartrate is a compound that binds to the 5-HT2A receptor. Labeled with the isotope fluorine-18 it is used as a radioligand in positron emission tomography (PET) studies of the brain.

Fet F-18 is an amino acid analog radiolabeled with fluorine F-18, a positron-emitting isotope, can be used as a tracer in positron emission tomography (PET).

MK-9470 is a selective, high-affinity reverse agonist and is also a fluorine 18 labeled positron emission tomography (PET) radiotracer [(18) F]. The MK-9470 has been used to image cannabinoid receptor type 1 in healthy and ill human brains.