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PIC1 PA是一种含有15个氨基酸的肽，是一种有效的PIC1类似物，能够抑制经典途径介导的补体激活。它在功能上干扰C1s-C1r-C1r-C1s MASPs与C1q MBL胶原样区(CLR)的交互作用。PIC1 PA可以特异性结合C1q的CLR，与纯化的C1q结合时的平均平衡解离常数(KD)为33.3 nM。

A1AR antagonist 5 (化合物 20) 是A1 腺苷受体(A1AR)的有效选择性拮抗剂，其pKi 值为 6.11，pIC50值为 5.83。

Tyrosinase-IN-17 (Compound 5b), characterized as a lipophilic, skin-permeable, and non-cytotoxic tyrosinase inhibitor (pIC 50 = 4.99), is suited for research into melanin-related diseases, including melanoma and melanogenesis [1].

NBI 35965 hydrochloride 是一种选择性、口服活性、能穿过血脑屏障的促肾上腺皮质激素释放因子受体 1 (CRF1) 拮抗剂，Ki 值为 4 nM，pKi 值为 8.5，并且不抑制 CRF2。NBI 35965 hydrochloride 可减少体内 CRF 或应激诱导的促肾上腺皮质激素 (ACTH) 生成，pIC50 值分别为 7.1 和 6.9，具有抗焦虑作用。

A1AR antagonist 6 (化合物 15) 是 A1 腺苷受体(A1AR)的有效的选择性拮抗剂，其pKi 值为 7.13，pIC50值为 6.38。

PDE12-IN-1 is a powerful and specific inhibitor of PDE12, exhibiting a pIC 50 value of 9.1 for enzyme inhibition. It effectively enhances levels of 2′,5′-linked adenylate polymers (2-5A), with a pEC 50 value of 7.7. Additionally, PDE12-IN-1 demonstrates antiviral activity.

IL-17A modulator-1 is an effective inhibitor of IL-17A activity, exhibiting a pIC 50 value of 8.2. This compound holds great promise for studying diseases and disorders that involve the modulation of IL-17A, such as immune-related diseases, autoimmune pathologies, cancer, and neurodegenerative disorders.