p136

KP136 (AL136) 是一种具有口服活性的抗过敏化合物，抑制组胺释放，可用于研究哮喘和过敏性水肿。

TOP1362 is a Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders. TOP1362 strongly inhibited the kinase targets p38α, Syk, Src, and Lck, blocked the rise in p38α expression in hyperosmolar Chang cells, and potently reduced inflammatory cytokine release in cellular models of innate and adaptive immunities. In the EIU model, TOP1362 dose-dependently attenuated the LPS-induced rise in inflammatory cell infiltration and ocular cytokine levels with efficacy comparable to that of dexamethasone.

Human PTHrP-(1-36) 为PTHrP的分泌形式，具抗尿酸效应，并能促进β细胞功能与增殖。该化合物可应用于研究恶性肿瘤体液性高钙血症（HHM）及甲状旁腺功能亢进症。

JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly. JAS239 attenuated choline phosphorylation and viability in a panel of human breast cancer cell lines. Antibody blockade prevented cellular retention of JAS239 indicating direct interaction with ChoKα independent of the choline transporters and catabolic choline pathways. In mice bearing orthotopic MCF7 breast xenografts, optical imaging with JAS239 distinguished tumors overexpressing ChoKα from their empty vector counterparts and delineated tumor margins.

Anticancer agent 218 (P136) 是一种属于喜树碱类的化合物，具有显著的抗癌活性。