osteoclastic

Clodronic acid disodium salt (Lodronate) 是一种口服具有活力的破骨细胞骨吸收 (osteoclastic bone resorption) 的抑制剂，是一代双磷酸盐。它可用于高骨转换状态、Paget’s 病和溶骨性骨转移中。

Cyt-PTPε Inhibitor-1 (A Inhibitor-1) 是胞质蛋白酪氨酸磷酸酶 ε 的抑制剂。 Cyt-PTPε Inhibitor-1 阻断 c-Src 的去磷酸化并表现出抗破骨活性。

3-(3-Hydroxyphenyl)propionic Acid (m-Hydroxyphenylpropionic acid) 是一种黄酮类代谢产物，由人体微生物区系形成，具有舒张血管的特性。

ABD-295 is an antiresorptive agent, osteoclast inhibitor, and biphenylsulfide derivative. ABD-295 has potent inhibitory effects on osteoclastic bone resorption in vitro. ABD-295 prevents ovariectomy-induced bone loss in vivo.

Deoxypyridinoline is one of two pyridinium cross-links that provide structural stiffness to type I collagen found in bones. It is excreted unmetabolized in urine and is a specific marker of bone resorption and osteoclastic activity.

PKC fragment (530-558) 是蛋白激酶C (PKC) 的肽片段，是一种有效的 PKC 激活剂。Protein Kinase C (530-558) 可显著抑制破骨细胞骨吸收。

Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) 是一种巴戟天中的蒽醌类化合物，能够抑制 NF-κB p65 的磷酸化和 IκBα 的降解以及减少 p65 的核转位，阻碍破骨细胞的骨吸收。

NFATc1-IN-1（亦称为compound A04）是通过抑制RANKL诱导的成骨细胞形成的高效抑制剂，其IC50为1.57 μM。它通过减少RANKL诱导的NFATc1核内转移来发挥抗成骨细胞生成效应。由于其显著的特性，NFATc1-IN-1对于推进与骨质疏松症相关研究具有重要潜力[1]。

NS-3736 is a chloride channel inhibitor that has been shown to prevent osteoclastic acidification and resorption.

Osteoprotegerin is a soluble secreted member of the tumor necrosis factor receptor superfamily, inhibiting osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, leading to excess accumulation of bone and cartilage.

Osteostatin为甲状旁腺激素相关蛋白(PTHrP) 107-111片段，该化合物在动物模型中促进骨缺损修复，预防炎症性关节炎引起的骨侵蚀，并抑制骨胶原诱导的关节炎及破骨细胞的吸收作用。Osteostatin主要应用于免疫炎症的研究领域。

Curculigoside B shows antioxidative and antiosteoporotic activities, it can decrease area of bone resorption pit, osteoclastic formation and TRAP activity.

Matairesinol 是一种植物木脂素，存在于多种食品中，如种子、蔬菜和水果。Matairesinol具有多种生物学功能，包括抗血管生成、抗癌和抗真菌活性；Matairesinol 的抗骨质疏松活性可能来自其通过 p38 ERK-NFATc1 信号传导的抗破骨潜力，而不是通过抗吸收作用。

3',4',7-Trihydroxyflavone 是分离自蚕豆荚的黄酮苷元化合物。

Dalbergiphenol shows antiosteoporotic activity, dalbergiphenol treatment can effectively prevent OVX-induced increase in bone loss and decrease in bone strength possibly by increasing osteoblastic activities and by decreasing osteoclastic activities.

Calcitonin, porcine 抑制1,25 (OH)2D3-刺激的猪破骨细胞分化。Calcitonin, porcine是一种多肽激素，通过减少肾脏对钙的重吸收和抑制破骨细胞的骨吸收来降低血清钙。Calcitonin, porcine可用于高钙血症的研究。