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27
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11428 |
Glyco-Obeticholic acid
|
FXR | Metabolism |
Glyco-obeticholic acid 是一种牛磺酸的特性代谢物。Obeticholic Acid 是口服具有活性的法尼样 X 受体激动剂。 | |||
T3424 |
Ezutromid
BMN 195,VOX-C1100,依珠曲米,SMT C1100 |
Others | Others |
Ezutromid (BMN 195) 是一种具有口服活性的、首创的苯并恶唑 utrophin 调节剂,EC50=0.91 μM。它抑制人肝微粒体 CYP1A2 酶活性,IC50=5.4 μM。它可用于 Duchenne 型肌营养不良症 (DMD) 的研究。 | |||
T20366 |
beta-Nicotyrine
bata-碱二烯,Nicotyrine,alpha-Nicotyrine |
Others | Others |
beta-Nicotyrine 是一种 Nicotine 的代谢物。它是一种微量的烟草生物碱,提取自普通烟草植物的叶子和香烟烟雾冷凝物。 | |||
T37683 |
3-Hydroxykynurenine
3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine |
Others | Others |
3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) 是色氨酸的活性代谢物,可抑制酵母和大鼠肝脏醛脱氢酶 97% 和 69%。 | |||
T1645 |
Ramipril
HOE-498,Tritace,雷米普利,Altace,Carasel |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Ramipril (Altace) 是一种ACE 抑制剂,IC50为5 nM。 | |||
T0255 |
Clomipramine hydrochloride
Clomipramine HCl,Anafranil,盐酸氯米帕明 |
Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine; GST | GPCR/G Protein; Neuroscience; oxidation-reduction |
Clomipramine hydrochloride (Anafranil) 是一种5-羟色胺转运体(Ki:0.14 nM)、去甲肾上腺素转运体(Ki:54 nM)和多巴胺转运体(Ki:3 nM)阻断剂。 | |||
T0109 |
Molsidomine
Morsydomine,SIN-10,吗多明,Corvaton |
NOD | Immunology/Inflammation; NF-κB |
Molsidomine (Corvaton) 是一种长效的、口服活性的血管扩张药,在肝脏中代谢可被为活性代谢物Linsidomine。 其中Linsidomine 是一种不稳定的化合物,能够产生NO,可用作血管舒张剂。 | |||
T0816 |
Acetohexamide
Acetohexamid,醋磺环已脲,Dymelor,醋磺己脲,Gamadiabet |
Potassium Channel; NADPH | Membrane transporter/Ion channel; Metabolism |
Acetohexamide (Acetohexamid) 是磺脲类试剂,可刺激胰腺分泌胰岛素,能够用于 2 型糖尿病的相关研究。 | |||
T37149 |
Carbamazepine 10,11-epoxide
|
Others | Others |
Carbamazepine 10,11-epoxide 是抗惊厥药卡马西平 (carbamazepine) 的活性代谢物。它由卡马西平通过微粒体中的细胞色素 P450 (CYP) 同种型 CYP3A4 和 CYP2C8 形成,微粒体分别由表达 CYP3A4 或 CYP2C8 的 HepG2 细胞制备。它对小鼠电击诱发的癫痫发作具有抗惊厥活性。 | |||
T12280 |
O-Desmethyl Midostaurin
CGP62221,O-Desmethyl PKC412 |
Others | Others |
O-Desmethyl Midostaurin is the active Midostaurin metabolite via cytochrome P450 liver enzyme metabolism. | |||
T36666 |
Dehydro Warfarin
|
||
Dehydro warfarin is a metabolite of (±)-warfarin .1It is formed from (±)-warfarin by rat liver microsomes. 1.Kaminsky, L.S., Fasco, M.J., and Guengerich, F.P.Comparison of different forms of liver, kidney, and lung microsomal cytochrome P-450 by immunological inhibition of regio- and stereoselective metabolism of warfarinJ. Biol. Chem.254(19)9657-9662(1979) | |||
T40397 |
3,4,6-Trichlorocatechol
|
||
3,4,6-Trichlorocatechol (TCC) is a metabolite generated by the post-mitochondrial liver fraction in Aroclor-1254 induced rats, resulting from exposure to industrial pollutants. | |||
T35543 |
Methyl Diethyldithiocarbamate
|
||
Methyl diethyldithiocarbamate is an active metabolite of the aldehyde dehydrogenase inhibitor disulfiram .1It is produced by methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes.2Methyl diethyldithiocarbamate inhibits liver low Kmaldehyde dehydrogenase (ALDH) in rats (ID50= 15.5 mg/kg).1It decreases mean arterial pressure (MAP) and increases heart rate during ethanol challenge in rats when administered at a dose of 20.6 mg/kg. 1.Hart, B.W., Yourick, J.J., and... | |||
T41015 |
Larsucosterol
DUR-928 |
||
Larsucosterol is a cholesterol metabolite from the nuclei of normal human liver tissues, epigenetically regulates the transcription of proteins and enzymes involved in lipid synthesis, inflammation, and apoptosis. | |||
T37430 |
Mirtazapine N-oxide
|
||
Mirtazapine N-oxide is a metabolite of mirtazapine.1It is formed from mirtazapine by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4 in human liver microsomes. | |||
T38556 |
Larsucosterol sodium
DUR-928 sodium |
||
Larsucosterol sodium is a cholesterol metabolite from the nuclei of normal human liver tissues, epigenetically regulates the transcription of proteins and enzymes involved in lipid synthesis, inflammation, and apoptosis. | |||
T35715 |
N-desmethyl Eletriptan
|
||
N-desmethyl Eletriptan is a metabolite of eletriptan .1It is formed from eletriptan primarily by the cytochrome P450 (CYP) isoform CYP3A4 in human liver microsomes. 1.Evans, D.C., O’Connor, D., Lake, B.G., et al.Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoproteinDrug Metab. Dispos.31(7)861-869(2003) | |||
T37307 |
Nordoxepin hydrochloride
|
||
Doxepin is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver. The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety of factors, including age, genetics, and drug-drug interactions. | |||
T36237 |
5-hydroxy Propranolol
|
||
5-hydroxy Propranolol is a metabolite of propranolol , a β-adrenergic receptor antagonist. Propranolol is primarily metabolized in the liver, with cytochrome P450 isoform 2D6 directing ring hydroxylation and the generation of 5-hydroxy propranolol and related metabolites. | |||
T35641 |
trans-hydroxy Glimepiride
|
||
trans-hydroxy Glimepiride is an active metabolite of the sulfonylurea glimepiride .1It is formed from glimepiride primarily in the liver by the cytochrome P450 (CYP) isoform CYP2C9. 1.Langtry, H.D., and Balfour, J.A.Glimepiride. A review of its use in the management of type 2 diabetes mellitusDrugs55(4)563-584(1998) | |||
T36507 |
Tetrachlorohydroquinone
|
||
Tetrachlorohydroquinone (TCHQ) is a metabolite of the organochlorine biocide pentachlorophenol. It is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of the mitochondrial membrane potential and necrosis in splenocytes. In vivo, TCHQ induces glutathione (GSH) depletion in mouse liver. | |||
T73777 |
Coproporphyrin I
|
||
Coproporphyrin I 是存在于血液和尿中的内源代谢物,可用于研究肝病和卟啉症。 | |||
T19360 |
Hydroxy bosentan
Ro 48-5033 |
Others | Others |
Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Hydroxy bosentan assists BOS pharmacologically, retaining 10%-20% activities. | |||
T35620 |
Ethoxyquin Dimer
|
||
Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin .1 It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induces microvesicular steatosis and hepatocyte necrosis, as well as increases liver levels of oxidized glutathione and total lipids in mice.2 | |||
T83421 |
1-Palmitoyl-sn-glycerol 3-phosphate
1-P-GPA |
||
1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA) 是内源性代谢物,常用于非酒精性脂肪性肝病的研究。 | |||
T35431 |
(±)-Clopidogrel (hydrochloride)
|
||
Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active metabolite via CYP2C19 in the liver enables its anti-aggregating activity. Marketed under the name Plavix , clopidogrel in combination with aspirin has been shown to be beneficial in the prevention of vascu... | |||
T36112 |
Clopidogrel Carboxylic Acid (hydrochloride)
|
||
Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active thiol metabolite via CYP2C19 in the liver enables its anti-aggregating activity. An estimated 15% of administered clopidogrel is metabolized by CYP2C19 to the thiol metabolite. Clopidogrel carboxylic acid i... | |||
T68919 |
Nabumetone Alcohol
|
||
Nabumetone alcohol is the alcohol form of nabumetone, a non-steroidal anti-inflammatory drug (NSAID) that is rapidly metabolized in the liver to a major active metabolite, 6-methoxy-2-naphthyl acetic acid, which inhibits the cyclooxygenase enzyme and preferentially blocks COX-2 activity (which is indirectly responsible for the production of inflammation and pain during arthritis). | |||
T78547 |
2-Phenyl-2-(2-pyridyl)acetonitrile
α-Phenyl-2-pyridineacetonitrile |
Drug Metabolite | Metabolism |
2-Phenyl-2-(2-pyridyl)acetonitrile 是 SC 15396 在大鼠肝脏匀浆上清中的主要代谢产物,后者为一种胃分泌抑制剂,作用于抗胃泌素受体。 | |||
T37584 | Tryptoquivaline D | ||
Tryptoquivaline D is a fungal metabolite that has been found inNeosartorya siamensisand has anticancer activity.1,2It induces nuclear chromatin condensation, a marker of apoptosis, in HCT116 colon and HepG2 liver cancer cells when used at a concentration of 150 μM.1Tryptoquivaline D (1-100 μM), alone or in combination with doxorubicin , reduces the viability of A549 lung cancer cells.2 | |||
T36920 |
16α-hydroxy Dehydroepiandrosterone
|
||
16α-hydroxy Dehydroepiandrosterone is a metabolite of the endogenous steroid hormone dehydroepiandrosterone .116α-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosteronevia16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as well as by fetal recombinant CYP3A7. It is a precursor to fetal estrogens, including estriol .2 1.Miller, K.K.M., Cai, J., Ripp, S.L., et al.Stereo- and regioselectivity account for the diversity of dehydro... | |||
T36415 |
N-Nitroso-N-methyl-4-Aminobutyric Acid
|
||
N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a tobacco-specific nitrosamine carcinogen.1It is oxidized to the reactive metabolite methyl-2-oxopropylnitrosamine (MOPN) in isolated rat liver mitochondria.2NMBA induces bladder transitional cell carcinomas in rats when administered in the drinking water at a concentration of 300 mg/L per day.3 | |||
T37854 |
Cholic Acid 7-sulfate
|
||
Cholic acid 7-sulfate is a metabolite of the primary bile acid cholic acid.[1],[2] It is produced by conjugation of a sulfate group with the hydroxy group at position 7 of cholic acid in the liver and gut. Fecal levels of cholic acid 7-sulfate are increased in male, but not female, mice fed a diet supplemented with cholic acid or chenodeoxycholic acid.[2] | |||
T37005 |
Estriol 3-β-D-Glucuronide (sodium salt)
|
||
Estriol 3-β-D-glucuronide is a metabolite of estriol . It is formed from estriol by the UDP-glucuronosyltransferase (UGT) isoform UGT1A10. Estriol 3-β-D-glucuronide binds to basolateral and canalicular liver plasma membranes with Kd values of 85 and 164 μM, respectively. It competitively inhibits the hydrolysis of 4-methylumbelliferyl-β-D-glucuronide and is a substrate for hydrolysis by Klotho-human IgG1 Fc protein (KLFc). | |||
T37229 |
(±)8,9-DiHETE
|
||
(±)8,9-DiHETE is a major metabolite of the 20:5 ω-3 fatty acid eicosapentaenoic acid .[1] It is produced in rat liver microsomes, but not renal microsomes, by the generation of the unstable intermediate 8,9-epoxy eicosatetraenoic acid from EPA by cytochrome P450 monooxygenases. Dietary EPA supplementation in humans results in substantial urinary excretion of vicinal diols, including 8,9, 11,12, and 14,15 forms.[2] | |||
T73762 |
11,12-DiHETrE
|
||
11,12-DiHETrE,一种细胞色素P450 (P450) 类二十烷素内源性代谢产物,用于早产研究,并可作为区分NAFL(非酒精性脂肪肝)与NASH(非酒精性脂肪性肝炎)的生物标志物。 | |||
T36794 |
Dolutegravir O-β-D-Glucuronide
|
||
Dolutegravir O-β-D-glucuronide is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed from dolutegravir primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1in vivobut is also metabolized by UGT1A9 in human liver and kidney microsomes and UGT1A3 in human intestinal microsomes.2,1 1.Liu, S.N., Lu, J.B., Watson, C.J.W., et al.Mechanistic assessment of extrahepatic contributions to glucuronidation of integrase strand transfer inhibitorsDrug Metab. Dispos.47(5)535-544... | |||
T74147 | Larsucosterol (trimethylamine) | ||
Larsucosterol (DUR-928) trimethylamine,一种胆固醇代谢物,有效的肝 X 受体 (LXR) 拮抗剂,同时作为内源性脂肪生成的调节剂。该化合物通过下调 mRNA 水平和抑制 SREBP-1 的激活,有效抑制胆固醇的生物合成。 | |||
T36397 |
TAN 420E
|
||
TAN 420E is a bacterial metabolite originally isolated from Streptomyces. It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 1.3 μM) and reduces thiobarbituric acid reactive substances (TBARS) in rat liver microsomes by 72% when used at a concentration of 100 μg/ml. TAN 420E is active against B. brevis, B. cereus, M. flavus, and S. aureus (MICs = 50-100 μg/ml). It is cytotoxic to P388 and KB lymphocytic leukemia cells (EC50s = 0.022 and 0.3 μg/ml, respectively). | |||
T83767 |
4-Hydroxyphenylglyoxylic Acid
UK 22486 |
||
4-Hydroxyphenylglyoxylic acid 是一种抑制剂,针对 carnitine palmitoyltransferase 1 (CPT1),同时也是前药 oxfenicine 的活性代谢物。在 200 至 1,000 µM 的浓度范围内,该化合物能够抑制离体大鼠肝线粒体中的 CPT1,并能够抑制离体大鼠肝细胞中的油酸氧化。 | |||
T36681 |
Sorafenib N-oxide
|
||
Sorafenib N-oxide is an active metabolite of sorafenib , an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD; Kd = 70 nM) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD (IC50 = 25.8 nM). It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3 (IC50s = 3.9-13.3 μM). Sorafenib N-oxide is also a linear-mixed inhibi... | |||
T37330 |
Pyridindolol
|
||
Pyrindolol is a bacterial metabolite that has been found inS. alboverticillatus.1It inhibits neutral β-galactosidase by 50% under acidic, but not neutral, conditions when used at a concentration of 2 μg/ml. It is selective for β-galactosidase isolated from bovine liver over β-galactosidases isolated from human, bovine, pig, and rat tissues and sialidases isolated fromC. perfringens,Streptomyces, and the H3N2 strain of influenza virus (IC50s = >250 μg/ml for all).1,2 1.Aoyagi, T., Kumagai, M., Ha... | |||
T37484 |
1-Salicylate Glucuronide
|
||
1-Salicylate glucuronide is a metabolite of salicylic acid and aspirin .1It is formed from salicylic acid primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A9 but also by a variety of other UGT isoforms and from aspirinviasalicylic acid as an intermediate. 1.Kuehl, G.E., Bigler, J., Potter, J.D., et al.Glucuronidation of the aspirin metabolite salicylic acid by expressed UDP-glucuronosyltransferases and human liver microsomesDrug Metab. Dispos.34(2)199-202(2006) | |||
T83858 |
Tauro-Obeticholic Acid sodium
Tauro-6-Ethylchenodeoxycholic Acid,Tauro-6-Ethyl-CDCA,Obeticholic Acid Taurine Conjugate,Tauro-OCA,T-ECDCA |
||
陶氏奥贝胆酸是奥贝胆酸的活性代谢物,属于法尼索德X受体(FXR)激动剂并且是熊脱氧胆酸的半合成衍生物。陶氏奥贝胆酸通过在肝脏中与牛磺酸结合形成,但可以通过肠道微生物被再次转换回奥贝胆酸。 | |||
T75141 | Aflatoxin Q1 | ||
Aflatoxin Q1是Aflatoxin B1 (AFB1)的羟基化代谢产物,后者由黄曲霉 (A. flavus) 产生的一种霉菌毒素。在人肝微粒体中,不论底物浓度高低,Aflatoxin B1的8,9-氧化物及Aflatoxin Q1均为其主要氧化产物。将Aflatoxin B1 3α-羟基化生成Aflatoxin Q1被视为一条重要的解毒途径。 | |||
T36807 |
Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)
|
||
Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.1It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km= 75 μM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.1,2In addition to binding to the MRP2 transport site, E217G has been shown to bind to an allosteric site that through positive cooperativity activates its own transportviaMRP2 and the transport of other MRP2 ... | |||
T74717 | 12-Hydroxynevirapine | ||
12-Hydroxyvirapine (12-hydroxy-NVP; 12-OH-NVP) 是奈韦拉平 的主要氧化代谢产物。奈韦拉平是一种非核苷类逆转录酶抑制剂,适用于 HIV-1感染,会引起特异性肝毒性和轻度至重度皮疹。12-Hydroxynevirapine 是一种非反应性代谢物,可被肝脏和皮肤中的磺基转移酶 (SULT) 生物激活,产生活性物质 12-Sulphoxy-nevirapine。 | |||
T35721 |
4’-hydroxy Trazodone
|
||
4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 μM) and is selective for OAT3 over OAT1 (Ki= >200 μM).2 1.Yamato, C., Takahashi, T., Fujita, T., et al.Studies on metabolism of trazodone, II. Metabolic fate after intravenous administration and effects on liver microsomal drug-metabolizing enzymes in ratsXenobiotica4(12)765-777(1974) 2.Zou, L., Matsson, P., Stecula, A., et al.Drug metabolites poten... | |||
T35708 | N-acetyl-5-Aminosalicylic Acid | ||
N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid and its prodrug form, sulfasalazine . It is formed in the liver, intestinal lumen, and colonic epithelial cells via N-acetyltransferases. It reduces IFN-γ binding to colonic epithelial cells by 24% when used at a concentration of 10 mM. N-acetyl-5-Aminosalicylic acid (100 μM) scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay and inhibits base hydroxylation in DNA stimulated by ... | |||
T37845 |
Taurocholic Acid 3-sulfate (sodium salt)
|
||
Taurocholic acid 3-sulfate (TCA3S) is a metabolite of the conjugated bile acid taurocholic acid .1Plasma levels of TCA3S are elevated in wild-type andSortilin 1(Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated inSort1knockout mice at 24 hours post-BDL.2 1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Li, J., Woolbright, B.L., Zhao, W., et al.Sortilin 1 loss-o... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13092 |
Tauro-Obeticholic acid
|
FXR | Metabolism |
Tauro-Obeticholic acid 是一种牛磺酸的特性代谢物。Obeticholic Acid 是口服具有活性的法尼样 X 受体激动剂。 | |||
TQ0274 |
27-Hydroxycholesterol
27-羟基胆固醇,5,25R-胆甾烯-3BETA,26-二醇,25(R)-27-hydroxy Cholesterol |
Estrogen/progestogen Receptor; Liver X Receptor | Endocrinology/Hormones; Metabolism |
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) 是一种有效的、选择性的雌激素受体调节剂和肝X 受体激动剂。 | |||
T7475 |
S-Adenosyl-L-methionine
AdoMet,Ademetionine,SAMe,S-Adenosyl methionine,S-腺苷-L-蛋氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
S-Adenosyl-L-methionine (Ademetionine) 是一种具有有效的抗抑郁和减轻疼痛作用的膳食补充剂,是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的,是一种重要的口服具有活力的甲基供体,能够用于肝病和骨关节炎的研究。 | |||
T5873 |
2,6-Dihydroxybenzoic acid
|
Endogenous Metabolite | Metabolism |
2,6-Dihydroxybenzoic acid 是一直水杨酸的次级代谢产物,在 I 期代谢过程中被肝酶水解。 | |||
T5233 |
N-Methylnicotinamide
N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide,N-甲基烟酰胺 |
Others; Endogenous Metabolite | Metabolism; Others |
N-Methylnicotinamide (Nicotinic Acid Methylamide) 是内源性代谢产物的一种。 | |||
T0738 |
Urea
尿素,Ureophil,Carbamide,E-Cardamoni,Carbonyldiamide |
Others; DHFR; Wnt/beta-catenin; Arginase; Endogenous Metabolite; Carbonic Anhydrase | Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Others; Stem Cells |
Urea (Carbonyldiamide) 在肝脏中由氨基酸脱氨产生的氨形成。它是蛋白质分解代谢的主要终代谢产物。 | |||
T0617 |
Nicotinamide N-oxide
Nicotinamide-N-oxide,Nicotinamide 1-oxide,N-氧代烟酰胺,烟酰胺-N-氧化物,1-oxynicotinamide |
c-Myc; Endogenous Metabolite; CXCR; Drug Metabolite | Autophagy; Cell Cycle/Checkpoint; GPCR/G Protein; Immunology/Inflammation; Metabolism |
Nicotinamide N-oxide (Nicotinamide 1-oxide) 是生物体内烟酰胺分解代谢物,是高效选择性CXCR2受体拮抗剂。 | |||
T3779 |
Crocin II
Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B |
Caspase; COX; NO Synthase | Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome |
Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物,具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达,还抑制NO 产生,IC50值为 31.1 μM。 | |||
T4876 |
2-(1H-Indol-3-yl)ethan-1-ol
Tryptophol,3-(2-Hydroxyethyl)indole,Indole-3-ethanol,色醇 |
Others; Endogenous Metabolite | Metabolism; Others |
2-(1H-Indol-3-yl)ethan-1-ol (3-(2-Hydroxyethyl)indole) 是在双硫仑治疗后在肝脏中形成的代谢物,可诱导人类睡眠。它也是酒精发酵的二次产物。 | |||
T1705 |
5-Amino-3H-imidazole-4-Carboxamide
4-Amino-5-imidazolecarboxamide,AICA,4-氨基-5-咪唑甲酰胺,5-Aminoimidazole-4-carboxamide |
Endogenous Metabolite | Metabolism |
5-Amino-3H-imidazole-4-Carboxamide (AICA) 是一种合成嘌呤(尤其是核碱基腺嘌呤和鸟嘌呤)的重要前体。 | |||
T13979 |
(S)-3-Hydroxybutanoic acid
L-β-Hydroxybutyric acid,(S)-β-Hydroxybutanoic acid,L-(+)-3-Hydroxybutyric acid,(S)-3-羟基丁酸 |
Endogenous Metabolite | Metabolism |
(S)-3-Hydroxybutanoic acid (L-(+)-3-Hydroxybutyric acid) 是一种正常的人体代谢产物,在患有抑郁症的老年患者中升高。它在人类的肝脏中由乙酰-CoA 合成,当血糖低时能够被脑用作能量来源。 | |||
T37067 |
9-hydroxy Stearic Acid
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HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
9-hydroxy Stearic Acid 是一种羟基脂肪酸,是9-PAHSA 的活性代谢物。9-hydroxy Stearic Acid 是由9-PAHSA 通过肝脏和胰腺的羧基酯脂肪酶形成的。9-hydroxy Stearic Acid (5 μM)抑制HT-29结肠癌细胞裂解物中组蛋白去乙酰化酶1 (HDAC1)的表达。3 .当浓度为100 μM.1时,可抑制HT-29细胞的增殖,并诱导细胞周期阻滞于G0/ g1期。 | |||
T5306 |
H-Abu-OH
L-2-氨基丁酸,L-Aminobutyric Acid,L-α-amino-n-Butyric acid,L(+)-2-Aminobutyric acid |
Others; Endogenous Metabolite | Metabolism; Others |
H-Abu-OH (L-α-amino-n-Butyric acid) 是氨基丁酸的三个同分异构体之一,它在患有雷氏综合征,同型血尿症,酪氨酸血症,非酮糖症以及鸟氨酸转氨酶症等代谢病儿童的血浆中的含量会明显升高。 | |||
T4938 |
Potassium 1H-indol-3-yl sulfate
硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate |
AhR; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) 是人芳烃受体(AhR)的激动剂。芳烃受体(AhR)最近被发现是免疫炎症条件的病理生理调节剂,Potassium 1H-indol-3-yl sulfate 已被证明是AhR的配体。Potassium 1H-indol-3-yl sulfate 也是膳食蛋白质中色氨酸的代谢物。色氨酸被肠道细菌代谢为吲哚,吲哚被吸收到血液中,然后在肝脏中进一步代谢为硫酸吲哚,通常通过尿液排出体外。在肾功能受损的慢性肾病患者中,Potassium 1H-indol-3-yl sulfate 可作为尿毒症毒素在血清中积累,诱导氧化应激并加速疾病进展。250 μM Potassium 1H-indol-3-yl sulfate 可诱导NF-Κb活化,促进大鼠近端小管细胞TGF-β1和Smad3的表达,与促纤维化活性相关。 | |||
T40796 |
5β-Dihydrocortisone
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5β-Dihydrocortisone is a sterol metabolite of cortisone by 5β-reductase (AKR1D1) in liver. | |||
T10805 | Cholesterol glucuronide | Others | Others |
Cholesterol glucuronide is an endogenous metabolite of lipid generated by UDP glucuonyltransferase in the liver. | |||
T38054 | Avenaciolide | ||
Avenaciolide is a water-insoluble fungal metabolite originally isolated from A. avenaceus. It inhibits glutamate transport in isolated rat liver mitochondria (Ki = 8 μM). | |||
T36776 |
Terpendole C
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Terpendole C is an indole diterpene alkaloid fungal metabolite originally isolated from A. yamanashiensis and an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 2.1 μM in rat liver microsomes). It also inhibits ACAT in J774 macrophages (IC50 = 0.46 μM) without affecting cell growth. | |||
T75454 | Penicitide A | ||
Penicitide A 是一种海洋次生代谢产物。Penicitide A 对病原体 A.brassicae 和人肝细胞肝癌 (HepG2) 细胞系显示中度细胞毒性。 | |||
T83264 |
6-Hydroxy-TSU-68
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6-Hydroxy-TSU-68为TSU-68的衍生物,此化合物为TSU-68在人肝微粒体生物转化路径中的代谢产物,其含量反映TSU-68的自诱导羟基化程度。 | |||
T83241 |
7-Hydroxy-TSU-68
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7-Hydroxy-TSU-68为TSU-68的衍生物,该化合物为TSU-68在人类肝微粒体内经生物转化途径形成的代谢产物,其含量标识了TSU-68自身诱导的羟基化程度。 | |||
T37774 |
Thielavin A
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Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H2 and the conversion of PGH2 to PGE2 . Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 μM; Ki = 27.8 μM). | |||
T37714 |
Fuscin
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Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities. It inhibits binding of the ADP/ATP translocase inhibitor atractyloside to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 μM in a radioligand binding assay. Fuscin (20 μM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-... | |||
T37690 |
Phenylpyropene A
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Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3 |1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of ... | |||
T83416 |
2-(Methylamino)benzoic acid
N-Methylanthranilic acid |
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2-(Methylamino)benzoic acid 为 methyl-N-methylanthranilates (MMA) 的主要代谢物,系通过酯基转化形成。此化合物可从柑橘中提取,并具备潜在的镇痛功能。2-(Methylamino)benzoic acid 亦应用于监测大鼠肝脏中 MMA 的代谢情况。 | |||
T37997 |
Murideoxycholic Acid
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Murideoxycholic acid (MDCA) is a secondary bile acid produced from α-muricholic acid and β-muricholic acid.[1] It is also a metabolite of lithocholic acid in liver S9 fractions from humans and other species.[2] MDCA prevents gallstone formation in hamsters fed a lithogenic diet but does not resolve gallstones in prairie dogs fed a high cholesterol diet.[3],[4] Gallstones formed during MDCA administration after a high cholesterol diet are comprised of an insoluble calcium salt of murideoxycholyl ... | |||
T36000 |
3-Hydroxyterphenyllin
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3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi... |