indoxyl

Indican (Indoxyl-β-D-glucoside) 是吲哚酚的一种糖苷，染料靛蓝和靛玉红的前体。它的主要代谢物是硫酸吲哚酚 (IS)。其中 IS 是尿毒症毒素，是有机阴离子转运蛋白1 (OAT 1)、OAT 3 和多药耐药相关蛋白4 (MRP 4) 的底物 抑制剂。

Indoxyl sulfate is a metabolite of tryptophan, showing adverse effects on bones and the central nervous system, having been most frequently implicated as a contributor to renal disease progression and vascular disease

3-Indoxyl caprylate 是用于检测细菌活性的化学发光底物,它可与特定酶反应配合使用.

3-Indoxyl butyrate 是 CES（羧酸酯酶）的显色底物，水解后会形成蓝色沉淀。

6-Chloro-3-indoxyl caprylate 是一种显色底物，用于检测具 C8 活性的酯酶。

3-Indoxyl phosphate (bis(2-amino-2-methyl-1,3-propanediol)) 一种在生化反应中使用的试剂。

Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40 6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). It also inhibits the organic anion transporter (OAT) isoforms OAT1 and OAT3 (Kis = 34.2 and 74.4 µM, respectively for the rat transporters) in S2 proximal tubule cells. Indoxyl sulfate (0.2 and 1 mM) increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells. It increases serum creatinine and blood urea nitrogen (BUN) levels in the 5 6 nephrectomized rat model of chronic renal failure when administered at a dose of 50 mg kg.

Indoxyl β-D-galactopyranoside 一种在生化反应中使用的试剂。

6-Chloro-3-indoxyl butyrate 一种在生化反应中使用的试剂。

5-Bromo-4-chloro-3-indoxyl palmitate 一种在生化反应中使用的试剂。

6-Chloro-3-indoxyl-β-D-cellobioside 是一种在生化反应中使用的试剂。

6-Chloro-3-indoxyl-N-acetyl-β-D-galactosaminide 一种在生化反应中使用的试剂。

6-Chloro-3-indoxyl phosphate (p-toluidine) 一种在生化反应中使用的试剂。

3-Indoxyl phosphate (p-toluidine) 一种在生化反应中使用的试剂。

AZ1366 is a potent tankyrase inhibitor that enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance. Combination AZ1366 and irinotecan achieved greater anti-tumor effects compared to monotherapy. Activity was limited to CRC explants that displayed irinotecan resistance and increased protein levels of tankyrase and NuMA.

Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) 是人芳烃受体(AhR)的激动剂。芳烃受体(AhR)最近被发现是免疫炎症条件的病理生理调节剂，Potassium 1H-indol-3-yl sulfate 已被证明是AhR的配体。Potassium 1H-indol-3-yl sulfate 也是膳食蛋白质中色氨酸的代谢物。色氨酸被肠道细菌代谢为吲哚，吲哚被吸收到血液中，然后在肝脏中进一步代谢为硫酸吲哚，通常通过尿液排出体外。在肾功能受损的慢性肾病患者中，Potassium 1H-indol-3-yl sulfate 可作为尿毒症毒素在血清中积累，诱导氧化应激并加速疾病进展。250 μM Potassium 1H-indol-3-yl sulfate 可诱导NF-Κb活化，促进大鼠近端小管细胞TGF-β1和Smad3的表达，与促纤维化活性相关。

5-Bromo-3-indoxylacetate 是一种GSK-3抑制剂，pIC50为3.39。

Simvastatin acid (Tenivastatin) calcium hydrate 是一种具有口服具有活力的 HMG-CoA 还原酶 (HMGCR) 抑制剂。Simvastatin acid calcium hydrate 能够调节心肌细胞和转染 OATP3A1 基因的 HEK293 细胞的 OATP3A1 表达。Simvastatin acid calcium hydrate 也能够抑制吲哚酚硫酸盐 (indoxyl sulfate) 介导的活性氧 (ROS) 产生。