eliciting

THIQ 是一种选择性黑皮质素 4 受体 (MC4R) 激动剂，对 hMC4R 和 rMC4R 的 IC50 分别为 1.2 和 0.6 nM。

4-Nonylphenol polyethoxylate (Nonoxinol-9) 是一种表面活性剂，普遍用作避孕药中的杀精剂。

Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素，是TRPV1的选择性激动剂，同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。

RMC-6291 是一种可口服且具有高效性的 KRASG12C(ON) 抑制剂，具有抗癌抗肿瘤活性，通过空间阻断 RAS 效应子结合来发挥作用。RMC-6291 阻断 ERK 信号传导，促使 KRASG12C 突变 H358 细胞凋亡。

3M-011, a potent dual toll-like receptor TLR7 8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibits H3N2 influenza viral replication in the nasal cavity and exhibits strong antitumor activity[1][2][3].

HQ-415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting an EC50 for HQ-415 is 15 μM.

Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-mediated rolesin vivo, as it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock.2,2NMU-25 is the active form of NMU in humans. It binds with high affinity to receptors on human left ventricle and coronary artery (KDs = 0.26 and 0.11 nM, respectively), eliciting endothelium-independent vasoconstriction.3NMU-25 also suppresses glucose-stimulated insulin secretion in human islets, and this effect is lost in NMU R165W mutants, resulting in early-onset obesity.4 1.Mitchell, J.D., Maguire, J.J., and Davenport, A.P.Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin SBritish Journal of Pharmacology15887-103(2009) 2.Greenwood, H.C., Bloom, S.R., and Murphy, K.G.Peptides and their potential role in the treatment of diabetes and obesityRev.Diabet.Stud.8(3)355-368(2011) 3.Mitchell, J.D., Maguire, J.J., Kuc, R.E., et al.Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular systemCardiovascular Research81353-361(2009) 4.Alfa, R.W., Park, S., Skelly, K.R., et al.Suppression of insulin production and secretion by a decretin hormoneCell Metabolism21(2)323-333(2015)

6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response. 6α-PGI1 exhibits an IC50 of 350 ng ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng ml).

LTB3 is the LTA hydrolase metabolite of LTA3 in the leukotriene biosynthetic pathway. LTB3 and LTB4 are equipotent in their pro-inflammatory effects. However, LTB3 is five times less potent than LTB4 in eliciting chemotaxis of human neutrophils.

Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Capsaicin signals are transduced by a heat-activated ion channel, the vanilloid receptor 1 (VR1), or transient receptor potential vanilloid 1 (TRPV1). CAY10448 is an iodinated nonivamide, a potent capsaicin receptor antagonist with an IC50 value of approximately 10 nM.

TET 830 modified T-helper epitope from tetanus toxoid is a T-cell stimulating peptide derived from tetanus toxoid. It acts as a helper peptide in vaccinations, eliciting T-cell responses.

PF4840154 是有效的大鼠和人TrpA1通道选择性激动剂，EC50分别为 97 和 23 nM。PF-4840154 可以诱导 TrpA1 介导的小鼠伤害行为。

OVA Peptide (323-339)是一种来自鸡卵清蛋白（OVA）的免疫优势表位肽，是主要的MHC II类限制性T细胞表位，能够特异性结合H2-IAd分子；同时也是一个B细胞表位，可被IgE抗体识别。常用于研究鸡蛋过敏。在小鼠中能够诱导强烈的Th2型免疫反应和IgE抗体的产生。

ProlactinReleasing Peptide (1-31), human (acetate) 是一款针对 GPR10 的高亲和力配体，并具备诱导催乳素释放的功能。该肽段与人类和大鼠的 GPR10 结合力极强，Ki 值分别为 1.03 nM 和 0.33 nM，适用于针对下丘脑-垂体轴进行的生物医学研究。

NDNA4（compound 17）作为Hsp90α选择性抑制剂，具有0.34 μM的IC50值。作为永久带电的类似物，该化合物显示出低膜渗透性，并在Ovcar-8和MCF-10A细胞中表现出较低的细胞毒性（IC50>100 μM）。NDNA4能够保护hERG通道免遭破坏，同时不触发热休克反应或引起对Hsp90α依赖的客户蛋白进行降解。

NDNA3 (compound 14)，一种选择性Hsp90α抑制剂，IC50为0.51 μM。该永久带电类似物具低膜渗透性，并对Ovcar-8细胞（IC50为12.66 μM）和MCF-10A细胞（IC50为11.72 μM）展现较低细胞毒性。NDNA3能够防止hERG通道成熟受损，不引发热休克反应或导致对Hsp90α依赖的客户蛋白降解。

PL-3994作为NPR-A的激动剂，展现了对中性肽酶的耐药特性，具有支气管扩张效应。对预收缩豚鼠气管，PL-3994表现出浓度依赖性的弛豫作用，其IC50值为42.7 nM。

Pezadeftide为一种抗真菌肽，能够穿透真菌细胞并迅速诱发线粒体反应，进而引起线粒体膜超极化。

Gly-Gly-Arg为一种三肽，其功能为孵化卵中的“泵信息素”。该化合物能诱导腹足泵活动，具有10 nM的阈值浓度，并展现出58.3%的最大百分比响应。在潮下甲壳类动物中，Gly-Gly-Arg作为信息素发挥作用，控制幼虫的释放。

2,3-Diphospho-D-glyceric acid pentasodium salt 是一种聚磷化合物，具有明显的阴离子性质。它在红细胞的凹中心起作用，通过结合血红蛋白降低氧亲和力。作为血管钙化 (VC) 的内源性选择性抑制剂，2,3-Diphospho-D-glyceric acid 能显著推迟结晶钙蛋白颗粒 (CPP) 的生成，并在小鼠血管平滑肌细胞系 (MOVAS) 中抑制钙化作用，同时不引起细胞毒性。

Platycodin D2 是分离自桔梗的皂苷类物质，显示除抗癌活性。

RGD Trifluoroacetate is a tripeptide that binds to integrins, effectively triggering cell adhesion, targeting specific cell lines, and eliciting particular cell responses. It is the most effective and frequently employed peptide for these purposes [RGD Trifluoroacetate].