ccn 3

Expression system: E. coli
Length: 28-357, Full Length of Mature Protein
Activity: Cell Activity

Expression system: Baculovirus Insect Cells
Length: 1-357, Full Length
Activity: Cell Activity

Expression system: HEK293 Cells
Length: 26-354, Partial
Activity: Not Tested

NOV CCN3 Protein, Rhesus, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 37.2 kDa and the accession number is A0A8J8Y4E9.

NOV CCN3 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.9 kDa and the accession number is A0A8C0RCV6.

Expression system: E. coli
Length: 24-354, Full Length of Mature Protein
Activity: Not Tested

PPP3CA, also known as protein phosphatase 2B, is a member of the PPP phosphatase family, PP-2B subfamily. It is the alpha catalytic subunit of protein phosphatase 2B (PP2B). PP2B is a holoenzyme that is comprised of a catalytic subunit associated with regulatory subunits. It is a calcium regulated enzyme that is activated by calmodulin and participates in the signaling cascades involved in development of the nervous, cardiovascular, and musculoskeletal systems. PPP3CA activates the T cells of the immune system and can be blocked by drugs. It also activates NFATc (a transcription factor) by dephosphorylating it. The activated NFATc is subsequently translocated into the nucleus, where it upregulates the expression of interleukin 2. PPP3CA interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. It also interacts with DNM1L. The interaction dephosphorylates DNM1L and regulates its translocation to mitochondria.