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抑制剂&激动剂
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TargetMol产品目录中 "b16-f10"的结果
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  • 抑制剂&激动剂
    41
    TargetMol | Inhibitors_Agonists
  • 多肽产品
    1
    TargetMol | Peptide_Products
  • 天然产物
    10
    TargetMol | Natural_Products
  • 疾病造模
    3
    TargetMol | Disease_Modeling_Products
  • 分子与细胞研究
    1
    TargetMol | Inhibitors_Agonists
  • fak-in-7
    T997319948-85-7
    FAK-IN-7 有潜在的抗增殖活性,是一种 FAK 抑制剂。
    • ¥ 131
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • Cabozantinib
    卡博替尼, XL184, BMS-907351
    T2586849217-68-1
    Cabozantinib (XL184) 是一种多靶点酪氨酸激酶受体抑制剂,可以抑制 VEGFR2、c-Met、Kit、Axl 和 Flt3 (IC50=0.035 1.3 4.6 7 11.3 nM)。Cabozantinib 具有抗肿瘤和抗血管生成活性。
    • ¥ 276
    In stock
    规格
    数量
  • Cabozantinib hydrochloride
    盐酸卡博替尼, XL184, Cabozantinib hydrochloride (849217-68-1(free base)), BMS-907351
    T51641817759-42-4
    Cabozantinib hydrochloride (XL184) 是一种有效的泛酪氨酸激酶抑制剂,可抑制 VEGFR2、c-Met、Kit、Axl 和 Flt4(IC50:0.035、1.3、4.6、7 和 6 nM)。
    • ¥ 248
    In stock
    规格
    数量
  • Methyl myristate
    肉豆蔻酸甲酯, methyl tetradecanoate
    TN6901124-10-7
    Methyl myristate (methyl tetradecanoate) 是一种肉豆蔻酸经酯化反应得到的饱和脂肪酸甲酯。对 B16F10 黑色素瘤具有显著的诱导作用。
    • ¥ 129
    In stock
    规格
    数量
  • Capsaicin
    天然辣椒素, Zostrix, Qutenza, 8-Methyl-N-vanillyl-trans-6-nonenamide, (E)-Capsaicin
    T1062404-86-4
    Capsaicin ((E)-Capsaicin) 属于天然产物,提取自辣椒,是一种 TRPV1 激动剂 (EC50=0.29 μM)。Capsaicin 具有抗肿瘤、抗炎、抗氧化、神经保护等活性。
    • ¥ 328
    In stock
    规格
    数量
    TargetMol | Inhibitor Hot
  • Dexamethasone
    地塞米松, Prednisolone F, NSC 34521, MK 125, Hexadecadrol
    T107650-02-2
    Dexamethasone (Hexadecadrol) 是一种糖皮质激素受体激动剂和一种 IL 受体调节剂。Dexamethasone 具有抗炎和免疫抑制活性,可诱导自噬。Dexamethasone 抑制 LPS 诱导的巨噬细胞炎症反应。
    • ¥ 198
    In stock
    规格
    数量
    TargetMol | Inhibitor Hot
  • Temozolomide
    替莫唑胺, TZM, TMZ, NSC 362856, CCRG 81045
    T117885622-93-1
    Temozolomide (TMZ) 是一种 DNA 烷基化剂,具有血脑屏障渗透性和口服活性。Temozolomide 具有抗肿瘤活性和抗血管生成活性,还可以诱导细胞凋亡和自噬。 Temozolomide 在酸性条件下稳定,在中性或微碱性条件下会发生水解。
    • ¥ 293
    In stock
    规格
    数量
    TargetMol | Inhibitor Hot
  • Vorinostat
    伏立诺他, suberoylanilide hydroxamic acid, SAHA, MK0683
    T1583149647-78-9
    Vorinostat (SAHA) 是一种泛的组蛋白脱乙酰酶 (HDAC) 抑制剂 (IC50=10 nM),对 HDAC1 2 3 6 7 11 均有抑制活性。 Vorinostat 具有抗肿瘤活性,可以诱导细胞分化,阻滞细胞周期,诱导细胞凋亡。
    • ¥ 326
    In stock
    规格
    数量
    TargetMol | Inhibitor Hot
  • Tamoxifen
    他莫昔芬, Z-Tamoxifen, trans-Tamoxifen, ICI47699
    T690610540-29-1
    Tamoxifen (ICI47699) 是一种雌激素受体调节剂 (SERM),具有选择性和口服有效性。Tamoxifen 对雌激素具有抑制活性 (如乳腺细胞) 和激活活性 (如骨、肝和子宫细胞)。
    • ¥ 108
    In stock
    规格
    数量
    TargetMol | Inhibitor Hot
  • Ursolic acid
    熊果酸, Urson, Prunol, NSC-4060, NSC 167406, Malol
    T072277-52-1
    Ursolic acid (Prunol) 属于天然产物,是一种五环三萜羧酸,提取自毛喉杜鹃。Ursolic acid 具有抗肿瘤、抗炎、抗菌、降血糖等活性。
    • ¥ 140
    In stock
    规格
    数量
  • Ribociclib
    瑞博西尼, LEE011
    T61991211441-98-3
    Ribociclib (LEE011) 是一种细胞周期蛋白依赖性激酶 CDK4 6 抑制剂 (IC50=10 39 nM),具有特异性和口服活性。Ribociclib 具有抗肿瘤活性,可以阻滞细胞周期,抑制肿瘤细胞增殖。
    • ¥ 233
    In stock
    规格
    数量
  • Calcitriol
    骨化三醇, Topitriol, Rocaltrol, RO215535, Calcijex, 1,25-Dihydroxyvitamin D3
    T631632222-06-3
    Calcitriol (1,25-Dihydroxyvitamin D3) 是一种维他命 D 的代谢物,一种维他命 D 受体 (VDR) 的激动剂 (IC50=0.4 nM)。Calcitriol 增加肠道对钙和磷的吸收,并与甲状旁腺激素一起增加了骨吸收。
    • ¥ 625
    In stock
    规格
    数量
  • L-Kynurenine
    L-犬尿氨酸, (S)-Kynurenine
    T49282922-83-0
    L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
    • ¥ 186
    In stock
    规格
    数量
    TargetMol | Inhibitor Sale
  • FR-167356
    FR167356, FR 167356
    T27371174185-16-1In house
    FR-167356 是 a3 异构体液泡型 H+-ATPase 的特异性抑制剂,对破骨细胞质膜、肾刷状缘膜和巨噬细胞微粒体的 IC50 分别为 170 nM、370 nM 和 220 nM。 FR-167356 减少 B16-F10 细胞的骨转移。
    • ¥ 828
    In stock
    规格
    数量
  • Antitumor agent-184
    T2002503040164-45-9
    Antitumor agent-184 (compound 12aa) 通过诱导细胞凋亡 (apoptosis) 显示出显著的抗肿瘤活性,其在 B16-F10 细胞、4T1 细胞和 CT26 细胞中的IC50值分别达到 2.35 μM、7.32 μM 和 10.31 μM。
    • ¥ 10600
    2-4周
    规格
    数量
  • IDO1/TDO-IN-7
    T200785
    IDO1 TDO-IN-7 (Compound 43b) 作为一种双重IDO1 TDO抑制剂的异喹啉衍生物,其IC50值分别为0.31 μM和0.08 μM。在B16-F10肿瘤模型中,该化合物展示了良好的药代动力学属性及显著的抗肿瘤效果,并具有较低的毒性。
    • 待询
    规格
    数量
  • D5B
    T203184
    D5B 是一种有效且选择性的PD-L1抑制剂,并经过DBCO修饰。其在4T1和B16-F10肿瘤细胞中对PD-L1的降解EC50分别为5.4 μM和6.2 μM。D5B 阻断PD-L1 PD-1相互作用,展现抗肿瘤活性。
    • 待询
    规格
    数量
  • Microtubule inhibitor 12
    T203573
    Microtubule inhibitor 12 (Compound 2k) 是一种抑制微管聚合 (microtubule polymerization) 的化合物,其IC50为 22.23 μM。它能够在G2 M期阻滞B16-F10细胞周期,诱导细胞凋亡 (apoptosis),并抑制细胞迁移。Microtubule inhibitor 12 抑制B16-F10、A549、HepG2和MCF-7癌细胞的增殖,IC50分别为0.098、0.135、0.109和0.259 μM。此外,Microtubule inhibitor 12 在小鼠模型中展现了抗肿瘤活性。
    • 待询
    规格
    数量
  • PD-L1/HDAC6-IN-1
    T2054032834094-36-7
    PD-L1 HDAC6-IN-1 (Compound HP29) 是一种同时抑制PD-L1和HDAC6的化合物,具有抑制PD-L1 PD-1相互作用和HDAC6活性的能力,IC50分别为26.8 nM和69 nM。该化合物增强了Jurkat T细胞对HepG2细胞的杀伤效能,IC50为3.4 μM。在大鼠体内,PD-L1 HDAC6-IN-1展示了良好的药代动力学特征,药物暴露度为871.62 ng·h mL,并且在小鼠B16-F10异种移植模型中表现出抗肿瘤活性。
    • 待询
    10-14周
    规格
    数量
  • BMP-22
    T361381306684-90-1
    BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM). It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine in vitro in a concentration-dependent manner. It inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 (0.5 mg/kg per day) decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis.
    • 待估
    35日内发货
    规格
    数量
  • Quinaldopeptin
    喹哪朵肽
    T36181130743-07-6
    Quinaldopeptin is a quinomycin antibiotic. It is active against a variety of bacteria, including S. pyogenes, S. aureus, C. perfringens, S. faecalis, E. coli, and K. pneumoniae (MICs = 0.2, 0.4, 0.8, 1.6, 3.1 and 6.3 μg ml, respectively). It is cytotoxic to B16 F10 and Moser cells (IC50s = 0.0008 and 0.04 μg ml, respectively) and increases survival in a P388 leukemia mouse model. Quinaldopeptin is a bis-intercalator depsipeptide (NPBID) that binds to and intercalates into DNA (Kd = 32 nM).
    • ¥ 6870
    35日内发货
    规格
    数量
  • CAY10736
    CAY10736
    T364602251753-61-2
    CAY10736 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal transition (EMT) of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10736 (5 mg/kg) reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model.References1. Liu, X., Li, B., Zhang, Z., et al. Synthesis and discovery novel anti-cancer stem cells compounds derived from the natural triterpenoic acids. J. Med. Chem. 61(23), 10814-10833 (2018). CAY10736 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal transition (EMT) of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10736 (5 mg/kg) reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model. References1. Liu, X., Li, B., Zhang, Z., et al. Synthesis and discovery novel anti-cancer stem cells compounds derived from the natural triterpenoic acids. J. Med. Chem. 61(23), 10814-10833 (2018).
    • 待估
    35日内发货
    规格
    数量
  • CAY10735
    CAY10735
    T364972251753-58-7
    CAY10735 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16 F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16 F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10735 (5 mg kg) reduces tumor growth in B16 F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model.References1. Liu, X., Li, B., Zhang, Z., et al. Synthesis and discovery novel anti-cancer stem cells compounds derived from the natural triterpenoic acids. J. Med. Chem. 61(23), 10814-10833 (2018). CAY10735 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16 F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16 F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10735 (5 mg kg) reduces tumor growth in B16 F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model. References1. Liu, X., Li, B., Zhang, Z., et al. Synthesis and discovery novel anti-cancer stem cells compounds derived from the natural triterpenoic acids. J. Med. Chem. 61(23), 10814-10833 (2018).
    • 待估
    35日内发货
    规格
    数量
  • CAY10763
    CAY10763
    T366452364458-49-9
    CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM, respectively). It reduces tumor growth in B16 F10 mouse melanoma and HepG2 mouse xenograft models when administered at doses of 100 and 10 mg kg, respectively. 1.Huang, R., Jing, X., Huang, X., et al.Bifunctional naphthoquinone aromatic amide-oxime derivatives exert combined immunotherapeutic and antitumor effects through simultaneous targeting of indoleamine-2,3-dioxygenase and signal transducer and activator of transcription 3J. Med. Chem.63(4)1544-1563(2020)
    • 待估
    35日内发货
    规格
    数量