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30
Cat. No. | Product Name | Target | Signaling Pathways |
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T0778 |
Phenacetin
非那西丁,Acetophenetidin |
COX | Immunology/Inflammation; Neuroscience |
Phenacetin (Acetophenetidin) 是一种非阿片类解热化合物,可用于缓解疼痛的研究。它是一种选择性的COX-3抑制剂,能作为人肝微粒体和大鼠体内 CYP1A2 的探针。 | |||
T9042 |
Teriflunomide impurity 3
4-Amino-N-(4-trifluoromethylphenyl)benzamide |
COX | Immunology/Inflammation; Neuroscience |
Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) 是一种选择性COX-1抑制剂,IC50为 30 µM。 | |||
T22398 |
Phenidone
菲尼酮,1-phenyl-3-pyrazolidinone |
Lipoxygenase; COX | Immunology/Inflammation; Metabolism; Neuroscience |
Phenidone (1-phenyl-3-pyrazolidinone) 是可口服发环氧化酶和脂氧合酶双重抑制剂,可改善实验性自身免疫性脑脊髓炎大鼠的瘫痪,降低自发性高血压大鼠的血压,可用作照片显像剂。 | |||
T23333 |
SC-58125
SC 58125,1-[(4-甲基磺酰基)苯基]-3-三氟甲基-5-(4-氟苯基)吡唑 |
COX | Immunology/Inflammation; Neuroscience |
SC-58125 是一种选择性的环氧合酶2 (COX-2)的抑制剂,IC50值为 0.04 μM。它在体内外均表现出抗肿瘤活性,还可抑制炎症部位的水肿并具有缓解疼痛作用。 | |||
T16328 |
Nitroaspirin
2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016 |
Apoptosis; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Nitroaspirin (NCX 4016) 是一氧化氮供体和阿司匹林的硝基衍生物,与 Aspirin 结合可抑制环氧合酶=,可作为 COX-1 的直接和不可逆抑制剂。 它通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白,显着诱导顺铂耐药人卵巢癌细胞的细胞周期停滞和凋亡,具有抗血栓和抗血小板特性。 | |||
T8656 |
CAY10404
3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T |
Apoptosis; Akt; COX | Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience; PI3K/Akt/mTOR signaling |
CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) 是一种有效且高度选择性的 COX-2 和 COX-1 抑制剂。 它还是 PKB/Akt 和 MAPK 信号通路的有效抑制剂,可诱导 NSC-LC 细胞凋亡,具有镇痛、抗炎和抗癌活性。 | |||
T8505 |
SC-236
4-(5-(4-氯苯基)-3-(三氟甲基)-1H-,Sc 236 |
Apoptosis; COX; PPAR | Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience |
SC-236 (Sc 236) 是一种具有口服活性的COX-2特异性抑制剂和PPARγ激动剂。它可通过 c-Jun 氨基端抑制激活蛋白-1活性,在小鼠模型中通过抑制 ERK 的磷酸化发挥抗炎作用。 | |||
T60992 |
COX-1/2-IN-3
|
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COX-1/2-IN-3 (Compound 7a) 是COX-1和COX-2 的双重抑制剂。COX-2-IN-3 具有低毒性的抗炎活性。 | |||
T61352 |
COX-2/5-LOX-IN-3
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COX-2/5-LOX-IN-3 (compound 5b) is a powerful and dual inhibitor of COX-2 and 5-LOX, with IC50 values of 45.73 μM, 5.45 μM, and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. This compound, COX-2/5-LOX-IN-3, shows promise for the investigation of inflammatory diseases [1]. | |||
T79361 |
COX-2/15-LOX-IN-3
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Lipoxygenase | Metabolism |
COX-2/15-LOX-IN-3 (compound 5k) 为COX-2/15-LOX的一种双重抑制剂,具有分别为0.075 μM和1.97 μM的IC50值。该化合物能显著抑制LPS诱导的细胞产生促炎细胞因子(IL-6, ROS和NO),表明其具备显著的抗炎活性。 | |||
T16950 |
Sudoxicam
舒多昔康,4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
COX | Immunology/Inflammation; Neuroscience |
Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) 是一种可逆的 COX 拮抗剂,具有抗炎、抗水肿和解热特性。 | |||
T1191L |
Metamizole sodium
安乃近,Analgin,安乃近钠盐(诺瓦经),Dipyron |
COX | Immunology/Inflammation; Neuroscience |
Metamizole sodium (Analgin) 是一种环氧合酶-3 (COX-3) 抑制剂,具有良好的解热作用,可用于缓解疼痛的研究。 | |||
T35610 |
2,5-dimethyl Celecoxib
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Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor | Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells |
2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂,mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。 | |||
T1421 |
Aceclofenac
醋氯芬酸,Preservex,Airtal |
COX | Immunology/Inflammation; Neuroscience |
Aceclofenac (Preservex) 是一种可口服的非甾体抗炎药,可用于缓解疼痛、骨关节炎、强直性脊柱炎、类风湿性关节炎的研究。 | |||
T0890 |
Mefenamic acid
CN-35355,CI 473,甲芬那酸,甲灭酸 |
COX | Immunology/Inflammation; Neuroscience |
Mefenamic acid (CN-35355) 是一种非甾体抗炎剂,可竞争性抑制hCOX-1和hCOX-2,IC50值分别为 40 nM 和 3 μM。 | |||
T6574 |
Lumiracoxib
Prexige,罗美昔布,COX-189 |
COX | Immunology/Inflammation; Neuroscience |
Lumiracoxib (Prexige) 是强选择性有口服活性的 COX-2抑制剂,Ki 值为 0.06 μM。它是非选择性非甾体抗炎试剂,具有抗炎和解热活性,可用于骨关节炎和骨癌研究。 | |||
T61760 | COX-2-IN-18 | ||
COX-2-IN-18 (Compound 3) is a highly effective COX-2 inhibitor with strong inhibitory activity against COX-2 (IC 50 = 0.775 μM). Its potency is comparable to the reference drug Celecoxib (IC 50 = 0.153 μM). This compound, COX-2-IN-18, shows promise in the field of cancer research [1]. | |||
T36457 |
CAY10416
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Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1. COX-2/5-LO inhibitors such as CAY10416 are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416 ... | |||
T60704 |
Loxoprofen sodium (dihydrate)
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Loxoprofen sodium dihydrate 是一种非甾体类口服抗炎药,具有镇痛和解热作用。Loxoprofen sodium dihydrate 显示出抗肿瘤活性,并且可减少动脉粥样硬化。Loxoprofen sodium dihydrate 是COX 的非选择性抑制剂,对 COX-1 和 COX-2 的IC50值分别为 6.5 和 13.5 μM。 | |||
T61606 |
Indomethacin sodium
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Indomethacin sodium, a powerful and orally active inhibitor of COX1/2, exhibits IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Apart from its potent anti-inflammatory effects, this compound possesses notable anticancer and anti-infective activities. Since it has such versatile attributes, it finds useful applicability in cancer, inflammation, and viral infection research [1] [2] [3]. | |||
T19574 |
TBHBA
2,4,6-Tribromo-3-hydroxybenzoic acid |
Others | Others |
TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid)是一种溴代芳香族化合物。它被发现可以抑制环氧合酶-2(COX-2)、脂氧合酶(LOX)、5-脂氧合酶类(5-LOX)、5-α还原酶和酪氨酸酶等,具有多种抗炎作用和抗氧化作用。 | |||
T71303 |
Flufenamic Acid-d4
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Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear... | |||
T36187 |
Celecoxib Carboxylic Acid
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Celecoxib carboxylic acid is an inactive metabolite of the COX-2 inhibitor celecoxib .1,2It is formed from celecoxib primarily by the cytochrome P450 (CYP) isoform CYP2C9. 1.Liu, H., Huang, X., Shen, J., et al.Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: Molecular docking and 3D QSAR analysesJ. Med. Chem.45(22)4816-4827(2002) 2.Kim, S.-H., Kim, D.-H., Byeon, J.-Y., et al.Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of celecox... | |||
T36418 |
O-Desmethyl-N-deschlorobenzoyl Indomethacin
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O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase.2It has also been used in the synthesis of prostaglandin D2receptor antagonists.3 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism ... | |||
T37919 |
Prostaglandin F1α
PGF1α,Prostaglandin F1α |
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Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10-11 M. [1] PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. [2] It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro. [3] | |||
T83773 |
Prostaglandin E2 Inhibitor 3
PGE2 Inhibitor 3 |
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Prostaglandin E2抑制剂3是一种microsomal prostaglandin E合酶-1 (mPGES-1; IC50 = 0.2 µM)的抑制剂,相较于COX-1、COX-2、5-lipoxygenase (5-LO)和soluble epoxide hydrolase (sEH),在10 µM的无细胞试验中表现出对mPGES-1的选择性。在10 µM和1 µM的浓度下,该抑制剂能抑制A549细胞中IL-1β诱导的PGE2生成以及在J774A.1巨噬细胞中,LPS诱导的IL-6和PGE2生成。同时,它还能抑制由钙离子载体A23187单独或结合花生四烯酸和A23187诱导的5-LO产物形成,包括白三烯B4 (LTB4) 和5-H(p)ETE(IC50s分别为4.9和5.2 µM)。在体内,10 mg/kg剂量的Prostaglandin E2抑制剂3能防止在zymosan诱导的小鼠腹膜炎模型中白细胞渗入腹腔液中。 | |||
T37634 |
17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
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Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM). | |||
T36070 |
(±)5(6)-EET
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5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhib... | |||
T36152 |
14S(15R)-EET
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14S(15R)-EET is an oxylipin and a cytochrome P450 metabolite of arachidonic acid .114S(15R)-EET binds to isolated guinea pig monocytes with a Kivalue of 612.5 nM in a competitive binding assay using [3H]14(15)-EET.2It induces dilation of precontracted isolated canine epicardial arterioles (EC50= 4 pM) and denuded porcine subepicardial arterioles (EC50= 3 pM).3Unlike 14R(15S)-EET, 14S(15R)-EET does not inhibit COX in enzyme assays or isolated platelets.4 1.Daikh, B.E., Lasker, J.M., Raucy, J.L., ... | |||
T37234 |
(±)14(15)-EpETE
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EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoi... | |||
T37235 |
(±)16(17)-EpDPA
(±)16,17-EpDPE,(±)16,17 EDP,(±)16,17-epoxy Docosapentaenoic Acid,(±)16,17-epoxy DPA,(±)16(17)-EpDPA |
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EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.[1],[2]Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET which are prime candidates for the actual active mediator.[3] However, the CYP450 metabolites of eicosapentaenoic acid and docosahex... | |||
T37238 |
(±)19(20)-EpDPA
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EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic... | |||
T36221 |
2-chloro Palmitic Acid
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2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endot... | |||
T35881 |
Resolvin E2
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Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m... | |||
T35791 | Palmitic acid-13C | ||
Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ... | |||
T35789 | Palmitic acid-1-13C | ||
Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 |1. Santos, M.J., López-Jurado, M., Llopis, J., et a... | |||
T36176 |
AMK (hydrochloride)
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AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7... | |||
T35597 |
Neuromedin U-23 (rat) (trifluoroacetate salt)
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Neuromedin U-23 (NMU-23) is a neuropeptide involved in diverse biological processes, including smooth muscle contraction, energy homeostasis, and nociception.1It is an agonist of neuromedin-U receptor 1 (NMUR1; EC50= 0.17 nM for the human receptor in a calcium mobilization assay using HEK293 cells) and NMUR2 (EC50= ~1.4-2 nM for arachidonic acid release in CHO cells expressing the human receptor).2,3NMU-23 (1 μM) induces contractions in isolated rat colon smooth muscle strips.4It decreases body ... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T3682 |
(-)-Catechin gallate
(-)-Catechin 3-O-gallate,儿茶素没食子酸酯,几茶素没食子酸酯,(-)-Catechin 3-gallate |
Others; COX | Immunology/Inflammation; Neuroscience; Others |
(-)-Catechin gallate ((-)-Catechin 3-O-gallate) 是绿茶儿茶素中的微量组分,可抑制COX-1和COX-2活性。它抑制人 Beta-secretase,对氯喹敏感的恶性疟原虫 NF54 和耐氯喹的恶性疟原虫 K1 具有抗疟原虫活性。 | |||
T2732 |
(-)-Epicatechin gallate
表儿茶素没食子酸酯,(−)-Epicatechin 3-gallate,Epicatechin gallate,(-)-Epicatechin 3-gallate,(-)-Epicatechin 3-O-gallate,ECG |
Virus Protease; COX; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
(-)-Epicatechin gallate ((-)-Epicatechin 3-O-gallate) 抑制环加氧酶-1 的IC50值为 7.5 μM。 | |||
TN2330 |
Phenethyl ferulate
Caffeic Acid 3-Methyl Phenethyl Ester,阿魏酸苯乙酯,阿魏酸苯乙醇酯 |
Lipoxygenase; COX | Immunology/Inflammation; Metabolism; Neuroscience |
Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) 对化学诱导的结肠癌具有化学预防特性,可增强偶氮甲烷诱导的结肠肿瘤的细胞凋亡。 它抑制环氧合酶(COX) 和 5-脂氧合酶 (5-LOX) ,IC50 值分别为 4.35 和 5.75 μM。 | |||
T3918 |
Ginsenoside Rb3
人参皂苷 Rb3,Gypenoside IV,人参皂苷Rb3 |
NF-κB; COX; NO Synthase | Immunology/Inflammation; Neuroscience; NF-κB |
Ginsenoside Rb3 (Gypenoside IV) 是从三七中提取的一种天然产物。它在 293T 细胞系中抑制 TNFα 诱导的NF-κB 转录活性,IC50为 8.2 μM。它还抑制COX-2和iNOSmRNA 的诱导。 | |||
TN1291 |
7,3',4'-Tri-O-methylluteolin
5-Hydroxy-3',4',7-trimethoxyflavone,木犀草素-7,3',4'-三甲醚 |
TNF; COX; Interleukin | Apoptosis; Immunology/Inflammation; Neuroscience |
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) 是来自草药马鞭草科的一种类黄酮,具有抗炎,解热,镇咳,抗糖尿病、抗癌和抗黑素生成特性。它以浓度依赖方式明显抑制促炎细胞因子,可显著降低在转录水平的诱导型一氧化氮合酶和环加氧酶-2 的 mRNA 表达。 | |||
T2S0618 |
β-Elemonic Acid
3-oxo Tirucallic Acid,β-岚香酮酸,Beta-Elemonic acid,3-Oxotirucallenoic Acid,β-榄香酮酸,Elemadienonic Acid |
Apoptosis; Reactive Oxygen Species; COX | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB |
β-Elemonic Acid (3-Oxotirucallenoic Acid) 是从乳香树中分离得到的一种三萜,具有抗癌和抗炎作用。它抑制脯氨酰内肽酶,诱导细胞凋亡,活性氧和COX-2表达。 | |||
T3342 |
Xanthohumol
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Apoptosis; Others; Influenza Virus; COX; Acyltransferase; HSV | Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; Others |
Xanthohumol 是从啤酒花中分离到的黄酮类化合物,可抑制 COX-1 和 COX-2 活性,具有抗肿瘤,抗血管生成的作用,还具有抗多种病毒的活性。 | |||
T10109 |
3-Carene
Delta-3-Carene |
COX; Antifungal | Immunology/Inflammation; Microbiology/Virology; Neuroscience |
3-Carene(Delta-3-Carene) 是西部落叶松和花旗松中提取的双环单萜烯,可做为植物杀菌剂。3-Carene 对痛觉刺激引起的炎症浸润和 COX-2 过表达有抑制作用。3-Carene 具有抗伤害作用,能促进成骨细胞分化的早期标志物碱性磷酸酶的活性和表达。 | |||
TC0036 |
Compound Lup-20(29)-en-3-yl acetate
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IL Receptor; VEGFR; Others; TNF; COX | Angiogenesis; Apoptosis; Immunology/Inflammation; Neuroscience; Others; Tyrosine Kinase/Adaptors |
Lup-20(29)-en-3-yl acetate 是 Lupeol 的衍生物,通过下调 TNF-α、IL-1β、MCP-1、COX-2、VEGF 和颗粒酶 B 来抑制类风湿性关节炎的进展。 | |||
T6S2023 |
Harpagoside
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Others; COX; NO Synthase | Immunology/Inflammation; Neuroscience; Others |
Harpagoside 是从爪钩草中分离出来的一种天然产物,可抑制COX-1和COX-2活性,并抑制 NO 的产生。 | |||
T4S0590 |
Columbin
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Phospholipase; COX; Parasite | Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience |
Columbin 是有口服活性的二萜呋喃内酯,选择性抑制COX-1和COX-2,EC50值为 327 μM 和 53.1 μM,具有抗炎和抗锥虫体作用。 | |||
T3399 |
Psoralidin
|
Others; Estrogen/progestogen Receptor; Reactive Oxygen Species; Lipoxygenase; Gamma-secretase; Akt; COX; Antibacterial | Cytoskeletal Signaling; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
Psoralidin 是COX-2和5-LOX 的抑制剂,有抗癌,抗菌和抗炎作用。它显著下调NOTCH1信号传导,还极大地诱导活化氧产生。 | |||
T5S1981 |
alpha-Cyperone
(+)-α-Cyperone,α-香附酮,α-Cyperone |
Others; Endogenous Metabolite | Metabolism; Others |
alpha-Cyperone (α-Cyperone) 与 IL-6, Cox-2, Cdc42, Nck-2, Rac1 的表达下调相关,从而能够抑制炎症反应。 | |||
T5S0045 |
Isofraxidin
6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶 |
MMP; ERK; p38 MAPK; TLR; COX | Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome |
Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分,抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞,抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达,还抑制TLR4/髓样分化蛋白 2 复合物的形成。 | |||
T3S0645 |
N-trans-Feruloyltyramine
Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺 |
Others; COX | Immunology/Inflammation; Neuroscience; Others |
N-trans-Feruloyltyramine (Feruloyltyramine) 是从大麻中分离得到的一种生物碱,是COX1和COX2的抑制剂,具有抗氧化和抗炎活性。 | |||
T4S2126 |
Ginkgetin
银杏双黄酮,银杏素 |
Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells |
Ginkgetin 是从银杏叶中分离得到的一种双黄酮,具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂,IC50值为 5.92 μM。 | |||
T6S1579 |
Monotropein
水晶兰苷,Monotropeine |
Others | Others |
Monotropein (Monotropeine) 是从Morinda officinalis 中获得,能够抑制硫酸葡聚糖硫酸钠诱导的结肠炎小鼠模型中炎性因子的表达。 | |||
T3417 |
Amentoflavone
Didemethyl-ginkgetin,穗花杉双黄酮,Amenthoflavone,3',8''-Biapigenin |
Apoptosis; P450; Phospholipase; Reactive Oxygen Species; Opioid Receptor; COX; Antibacterial; RSV; Antifungal | Apoptosis; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB |
Amentoflavone (3',8''-Biapigenin) 是一种具有很多生物活性的双黄酮类天然产物,有抗炎、抗氧化和神经保护等作用。 | |||
T3S1553 |
trans-Cinnamaldehyde
Cinnamaldehyde,Cinnamic aldehyde,桂皮醛,反式肉桂醛,Cinnamal,Phenylacrolein |
COX; Endogenous Metabolite | Immunology/Inflammation; Metabolism; Neuroscience |
trans-Cinnamaldehyde (Phenylacrolein) 是一种能够用于合成反式肉桂醛-β-环糊精复合物,一种能够食用的抗菌涂层,能够延长鲜切水果的保质期。它是一种能够通过烷基异氰化物与乙炔二羧酸二烷基酯的反应来合成高度多官能的呋喃环。 | |||
T4S2326 |
Cornuside
7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside |
ERK; p38 MAPK; NF-κB; JNK | MAPK; NF-κB |
Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷,可用于炎症疾病的研究和促进血液循环。 它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应,用于炎性过敏性疾病中的潜能。 | |||
T6S1917 |
Schisandrol B
Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B |
P450; Reactive Oxygen Species; Autophagy | Autophagy; Immunology/Inflammation; Metabolism; NF-κB |
Schisandrol B (Besigomsin) 是华中五味子的主要活性成分,具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生,也抑制 P-糖蛋白和CYP3A 的活性。 | |||
T7030 |
anemarsaponin B
知母皂苷B,知母皂苷 B |
p38 MAPK; NF-κB; MEK; COX; NO Synthase | Immunology/Inflammation; MAPK; Neuroscience; NF-κB |
Anemarsaponin B 是一种甾体皂苷,可降低iNOS 和COX-2的蛋白和 mRNA 水平,减少促炎细胞因子的表达和产生。它通过阻断 IκBα 的磷酸化来抑制NF-κB 的 p65 亚基的核转位,还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 的磷酸化。 | |||
T6S1684 |
8-Gingerol
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Antioxidant; Antibacterial; TRP/TRPV Channel | Membrane transporter/Ion channel; Microbiology/Virology; oxidation-reduction |
8-Gingerol 分离自姜的根状茎,是口服有效的 TRPV1激活剂,EC50值为5.0 µM。8-Gingerol 抑制 COX-2,还能抑制体外 H. pylori 的生长。 | |||
T6S1572 |
Sauchinone
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ERK; p38 MAPK; NF-κB | MAPK; NF-κB |
Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS,TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。 | |||
T6S1487 |
Ginsenoside Rg5
人参皂苷Rg5,人参皂甙 Rg5 |
NF-κB; COX; IGF-1R | Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors |
Ginsenoside Rg5 是红参的主要成分,可阻断IGF-1与其受体的结合,IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压,具有抗炎和治疗阿尔茨海默病的潜力。 | |||
T3779 |
Crocin II
Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B |
Caspase; COX; NO Synthase | Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome |
Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物,具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达,还抑制NO 产生,IC50值为 31.1 μM。 | |||
TN1606 |
(-)-Epiafzelechin
(-)-表阿夫儿茶精,表阿夫儿茶精 |
COX | Immunology/Inflammation; Neuroscience |
(-)-Epiafzelechin exhibits significant anti-inflammatory activity on carrageenin-induced mouse paw edema, it exhibits a dose-dependent inhibition on the COX activity with an IC50 value of 15 microM, it exhibits about 3-fold weaker inhibitory potency on th | |||
TMA0291 | Dehydroglyasperin D | GSK-3; p38 MAPK; ROS; Akt; COX; PI3K; DNA/RNA Synthesis; Prostaglandin Receptor; JNK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells |
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction with phosphatidylinositol 3-kinase; it also mediates suppression of both COX-2 expression and the MLK3 signalling pathway through direct binding and inhibition of MLK3. Dehydroglyasperin D shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet o... | |||
T38330 |
Collinin
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Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a... | |||
T35741 |
Gliovirin
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Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease... |