A-7 hydrochloride

A-7 hydrochloride 是一种钙调蛋白拮抗剂，会引起 MDA-MB-231细胞中 CD44+CD24-亚群的改变。

PKRA83 hydrochloride hydrate是一种高效的促动力拮抗剂，与PK2及其受体PKR1和PKR2进行竞争性结合。该化合物在抑制PK2受体方面表现出色，其对PKR1和PKR2的IC50值分别为5.0 nM和8.2 nM。此外，PKRA83 hydrochloride hydrate还具备抗癌、抗关节炎以及抗血管生成的活性，并能够穿透血脑屏障。

CRA-026440 hydrochloride 是有效的、广谱的 HDAC 抑制剂。CRA-026440 hydrochloride 作用于 HDAC1，HDAC2，HDAC3，HDAC6，HDAC8 和 HDAC10， Ki 值分别为 4 nM，14 nM，11 nM，15 nM，7 nM 和 20 nM。CRA-026440 hydrochloride 具有抗血管生成和抗肿瘤活性。

TG 100572 Hydrochloride 是一种多靶点激酶抑制剂，能够抑制受体酪氨酸激酶和Src 激酶。

KAPA hydrochloride (7-keto-8-Aminopelargomic Acid HCl) 是一种生物素合成中间体。

Irinotecan Hydrochloride (CPT-11 hydrochloride) 是喜树碱半合成衍生物的盐酸盐，是一种拓扑异构酶 I 抑制剂，可研究结肠癌和直肠癌。

Demeclocycline hydrochloride (Declomycin) 是四环素类抗生素，可治疗粉刺，莱姆病和支气管炎。

Regorafenib Hydrochloride (BAY73-4506 hydrochloride) 是一种新型口服多激酶抑制剂，可抑制血管生成、基质和致癌受体酪氨酸激酶，具有强大的临床前抗肿瘤活性。它靶向作用于 VEGFR1 2 3、PDGFRβ、Kit、RET 和 Raf-1，IC50值分别为 13 4.2 46、22、7、1.5 和 2.5 nM。

ML-7 hydrochloride (ML-7 HCl) 是一种可渗透细胞的、可逆的、有效的、ATP 竞争性的肌球蛋白轻链激酶(MLCK) 特异性抑制剂，IC50为300 nM。它还抑制平滑肌肌球蛋白轻链激酶、PKA 和 PKC。

SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.IC50 value: 9.0(pKi) [1]Target: 5-HT2C antagonistin vitro: SB 242084 had over 100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors. In studies of 5-HT-stimulated phosphatidylinositol hydrolysis using SH-SY5Y cells stably expressing the cloned human 5-HT2C receptor, SB 242084 acted as an antagonist with a pKb of 9.3, which closely resembled its corresponding receptor binding affinity [1].in vivo: SB 242084 potently inhibited m-chlorophenylpiperazine (mCPP, 7 mgkg i.p. 20 min pre-test)-induced hypolocomotion in rats, a model of in vivo central 5-HT2C receptor function, with an ID50 of 0.11 mg kg i.p., and 2.0 mg kg p.o. SB 242084 (0.1-1 mg kg i.p.) exhibited an anxiolytic-like profile in the rat social interaction test, increasing time spent in social interaction, but having no effect on locomotion. SB 242084 (0.1-1 mg kg i.p.) also markedly increased punished responding in a rat Geller-Seifter conflict test of anxiety, but had no consistent effect on unpunished responding [1].

Idarubicin hydrochloride (Zavedos) 是一种蒽环类抗白血病药物，能抑制细菌和酵母菌生长，还抑制拓扑异构酶 II，干扰 DNA 复制和 RNA 转录。

HCV-IN-7 hydrochloride is an orally active and potent pan-genotypic HCV NS5A inhibitor (IC50s: 3-47 pM). It shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake.

Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).

JMV 2959 hydrochloride (925238-89-7 free base) 是一种生长激素促分泌素受体 1a 型 (GHS-R1a) 拮抗剂，在 LLC-PK1 细胞中的 IC50 为 32±3 nM。

MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAM

TG 100801 Hydrochloride is a prodrug to treat age-related macular degeneration. TG 100572 is a inhibitor of multi-targeted kinase(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src,

CMP-5 hydrochloride is a potent and selective PRMT5 inhibitor, while displays no activity against PRMT1 4 7 enzymes. It selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations.

Tesmilifene hydrochloride 是一种兼具抗组胺和化学增敏作用的化合物。该化合物通过靶向细胞色素P450 (cytochrome P450)，在MCF-7细胞中引发DNA合成的激素效应，并促进小鼠和大鼠模型中的肿瘤生长。此外，Tesmilifene hydrochloride 能够克服多药耐药性。

W-7 hydrochloride (W-7 HCl) 是一种选择性的钙调蛋白拮抗剂。它抑制Ca2+-钙调蛋白依赖性磷酸二酯酶和肌球蛋白轻链激酶，IC50值分别为 28 μM 和 51 μM。它可诱导细胞凋亡，具有抗癌活性。

Imiquimod hydrochloride (R 837 hydrochloride) 是一种选择性的 toll 样受体 7 (TLR7) 激动剂和免疫反应调节剂，具有抗病毒和抗肿瘤活性。Imiquimod hydrochloride 可用于研究天疱疮叶状疱疮、皮肤癌和银屑病。

Facinicline hydrochloride (RG3487) 是一种口服有效的烟碱α7 receptor 部分激动剂，对人 nAChR 的 Ki 值为 6 nM。它可改善啮齿类动物的认知和感觉运动门控。它与5-HT3受体结合的 Ki 为 1.2 nM。

Theophylline, 7-(2-(diethylamino)ethyl)-6-thio-, hydrochloride is a bioactive chemical.

Theophylline, 7-(2-oxo-4-piperidinobutyl)-6-thio-, hydrochloride is a bioactive chemical.

GRKs-IN-1 hydrochloride, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=130 nM) and GRK5 (IC50=7.1 μM).GRKs-IN-1 hydrochloride is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine[1]. [1]. Waldschmidt HV, et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13;60(7):3052-3069.