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| Cat. No. | Product Name | Target | Signaling Pathways |
|---|---|---|---|
| T22538 | A-7 hydrochloride | CaMK | Neuroscience |
| A-7 hydrochloride 是一种钙调蛋白拮抗剂，会引起 MDA-MB-231细胞中 CD44+CD24-亚群的改变。 | |||
| T20792 |
W-7 hydrochloride
N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐,W-7 HCl,W 7 HCl,W7 HCl |
CaMK; Apoptosis; Myosin; PDE | Apoptosis; Cytoskeletal Signaling; Metabolism; Neuroscience |
| W-7 hydrochloride 是一种选择性的钙调蛋白拮抗剂。它抑制Ca2+-钙调蛋白依赖性磷酸二酯酶和肌球蛋白轻链激酶，IC50值分别为 28 μM 和 51 μM。它可诱导细胞凋亡，具有抗癌活性。 | |||
| T28531 |
Facinicline hydrochloride
RG3487 |
AChR; 5-HT Receptor | GPCR/G Protein; Neuroscience |
| Facinicline hydrochloride 是一种口服有效的烟碱α7 receptor 部分激动剂，对人 nAChR 的 Ki 值为 6 nM。它可改善啮齿类动物的认知和感觉运动门控。它与5-HT3受体结合的 Ki 为 1.2 nM。 | |||
| T10883L |
CRA-026440 hydrochloride
CRA-026440 hydrochloride（847460-34-8 Free base） |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
| CRA-026440 hydrochloride 是有效的、广谱的 HDAC 抑制剂。CRA-026440 hydrochloride 作用于 HDAC1，HDAC2，HDAC3，HDAC6，HDAC8 和 HDAC10， Ki 值分别为 4 nM，14 nM，11 nM，15 nM，7 nM 和 20 nM。CRA-026440 hydrochloride 具有抗血管生成和抗肿瘤活性。 | |||
| T1400 |
Demeclocycline hydrochloride
Detravis,Clortetrin,地美环素,盐酸地美环素,Demeclocycline HCl,Declomycin |
Antibiotic; ribosome; Antibacterial | Microbiology/Virology |
| Demeclocycline hydrochloride 是四环素类抗生素，可治疗粉刺，莱姆病和支气管炎。 | |||
| T6010 |
Idarubicin hydrochloride
盐酸伊达比星,伊达比星盐酸盐,Zavedos,Idarubicin HCl,4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl,Idamycin,4-Demethoxydaunorubicin hydrochloride |
Autophagy; Antibacterial; Topoisomerase; Antifungal | Autophagy; DNA Damage/DNA Repair; Microbiology/Virology |
| Idarubicin HCl 是一种蒽环类抗白血病药物，能抑制细菌和酵母菌生长，还抑制拓扑异构酶 II，干扰 DNA 复制和 RNA 转录。 | |||
| T0486L |
Irinotecan Hydrochloride
盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride |
Topoisomerase; Autophagy | Autophagy; DNA Damage/DNA Repair |
| Irinotecan Hydrochloride 是喜树碱半合成衍生物的盐酸盐，是一种拓扑异构酶 I 抑制剂，可研究结肠癌和直肠癌。 | |||
| T4261 | BPR1J-097 hydrochloride (1327167-19-0(free base)) | FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
| BPR1J-097 hydrochloride (1327167-19-0(free base)) 是一种新型小分子 FLT-3抑制剂(IC50=11±7 nM)，具有很好的体内抗肿瘤活性。 | |||
| T5164 |
Cabozantinib hydrochloride
Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351,XL184,盐酸卡博替尼 |
c-Met/HGFR; TAM Receptor; ROR; VEGFR; FLT; c-Kit | Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors |
| Cabozantinib hydrochloride 是一种有效的泛酪氨酸激酶抑制剂，可抑制 VEGFR2、c-Met、Kit、Axl 和 Flt4（IC50：0.035、1.3、4.6、7 和 6 nM）。 | |||
| T11719 |
JMV 2959 hydrochloride (925238-89-7 free base)
JMV 2959 hydrochloride |
GHSR | GPCR/G Protein |
| JMV 2959 hydrochloride (925238-89-7 free base) 是一种生长激素促分泌素受体 1a 型 (GHS-R1a) 拮抗剂，在 LLC-PK1 细胞中的 IC50 为 32±3 nM。 | |||
| T8402 |
Regorafenib Hydrochloride
瑞戈非尼盐酸盐,BAY73-4506 hydrochloride |
c-RET; PDGFR; VEGFR; Autophagy; Raf | Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors |
| Regorafenib Hydrochloride 是一种新型口服多激酶抑制剂，可抑制血管生成、基质和致癌受体酪氨酸激酶，具有强大的临床前抗肿瘤活性。它靶向作用于 VEGFR1/2/3、PDGFRβ、Kit、RET 和 Raf-1，IC50值分别为 13/4.2/46、22、7、1.5 和 2.5 nM。 | |||
| T3050 |
ML-7 hydrochloride
ML-7盐酸盐,ML-7 HCl |
PKC; Serine/threonin kinase; PKA; YAP; Myosin | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors |
| ML-7 hydrochloride 是一种可渗透细胞的、可逆的、有效的、ATP 竞争性的肌球蛋白轻链激酶 (MLCK) 特异性抑制剂，IC50为300 nM。它还抑制平滑肌肌球蛋白轻链激酶、PKA 和 PKC。 | |||
| T4690 |
Betrixaban hydrochloride(330942-05-7(free base))
PRT054021 hydrochloride,盐酸贝曲西班 |
Factor Xa | Metabolism |
| Betrixaban hydrochloride(330942-05-7(free base)) 是一种有效的、选择性的、口服有效的 Xa 因子 (fXa) 抑制剂 (IC50: 1.5 nM)。 | |||
| T11638 |
Ilorasertib hydrochloride
ABT-348 hydrochloride |
Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
| Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 n | |||
| T12025 | MFZ 10-7 hydrochloride | GluR | Neuroscience |
| MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAM | |||
| T34836 | Theophylline, 7-(2-(diethylamino)ethyl)-6-thio-, hydrochloride | ||
| Theophylline, 7-(2-(diethylamino)ethyl)-6-thio-, hydrochloride is a bioactive chemical. | |||
| T63095 | GNE 220 hydrochloride | ||
| GNE 220 (hydrochloride) 是一种有效的、选择性的 MAP4K4 抑制剂 (IC50: 7 nM)。 | |||
| T34838 | Theophylline, 7-(2-oxo-4-piperidinobutyl)-6-thio-, hydrochloride | ||
| Theophylline, 7-(2-oxo-4-piperidinobutyl)-6-thio-, hydrochloride is a bioactive chemical. | |||
| T61724 | SB 258741 hydrochloride | ||
| SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1]. | |||
| T62102 | Elimusertib hydrochloride | ||
| Elimusertib (BAY 1895344) hydrochloride 是一种有效的、选择性的、口服具有活力的 ATR 抑制剂 (IC50: 7 nM)，表现出抗肿瘤作用。Elimusertib hydrochloride 能够用于研究实体瘤和淋巴瘤。 | |||
| T39641 |
SHP2-IN-6 hydrochloride
SHP2-IN-6 hydrochloride |
||
| SHP2-IN-6 hydrochloride, derived from compound 7 of patent WO2017211303A1, is a highly potent inhibitor of SHP2 with an IC50 of 25.8 nM. | |||
| T63622 | RF9 hydrochloride | ||
| RF9 hydrochloride 是有效的、选择性的神经肽 FF 受体 (Neuropeptide FF receptor) 拮抗剂，能够作用于 hNPFF1R (Ki: 58 nM) 和 hNPFF2R (Ki: 7 nM)。 | |||
| T11548L | HCV-IN-7 hydrochloride | Others | Others |
| HCV-IN-7 hydrochloride is an orally active and potent pan-genotypic HCV NS5A inhibitor (IC50s: 3-47 pM). It shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake. | |||
| T19243 | CMP-5 hydrochloride | Others | Others |
| CMP-5 hydrochloride is a potent and selective PRMT5 inhibitor, while displays no activity against PRMT1/4/7 enzymes. It selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. | |||
| T22091 | Imiquimod hydrochloride | ||
| Imiquimod hydrochloride (R 837 hydrochloride)是一种免疫反应调节剂，是一种选择性的 toll 样受体 7 (TLR7) 激动剂。Imiquimod hydrochloride 在体内表现出抗病毒和抗肿瘤作用。Imiquimod hydrochloride 可用于外生殖器、肛周疣、癌症和 COVID-19 的研究。 | |||
| T11443L |
GNE 220 Hydrochloride (1199590-75-4 free base)
GNE 220 Hydrochloride |
Others | Others |
| GNE 220 Hydrochloride is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM). | |||
| T13157L | TG 100801 Hydrochloride | VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
| TG 100801 Hydrochloride is a prodrug to treat age-related macular degeneration. TG 100572 is a inhibitor of multi-targeted kinase(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, | |||
| T71764 | YM 298198 Hydrochloride | ||
| YM 298198 Hydrochloride is a non-competitive antagonist with high affinity and selectivity for mGlu1 receptors (Ki = 19 nM). YM 298198 Hydrochloride is inactive at other mGlu receptor subtypes (mGlu2-7), ionotropic receptors and glutamate transporters (IC50 > 10 μM). It inhibits glutamate-induced IP production more potently than CPCCOEt (IC50 values are 16 nM and 6.3 μM respectively). | |||
| T36231 | Rac-7-hydroxy Propranolol (hydrochloride) | ||
| rac-7-hydroxy Propranolol (hydrochloride) is a ring-hydroxylated isomer and metabolite of propranolol that is an antagonist at β-adrenergic receptors (0.95 potency relative to propranolol). It also demonstrates potent vasodilator activity (0.20 potency relative to propranolol; pA2 = 7.58). | |||
| T13156L | TG 100572 Hydrochloride | VEGFR; FGFR; PDGFR; Src | Angiogenesis; Tyrosine Kinase/Adaptors |
| TG 100572 Hydrochloride 是一种多靶点激酶抑制剂，能够抑制受体酪氨酸激酶和Src 激酶。 | |||
| T68262 | AEG40826 | ||
| AEG40826 (HGS1029) is the hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with potential antineoplastic activity. IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhib... | |||
| T70235 | Cemadotin hydrochloride | ||
| Cemadotin hydrochloride is the salt from of Cemadotin (free base), also known as, LU103793, a mitosis inhibitor potentially for the treatment of solid tumours. Cemadotin is also a synthetic derivative of Dolastatin 15, an antiproliferative compound which was isolated from the mollusk Dolabella auricularia. Like Dolastatin 15, LU103793 is highly cytotoxic in vitro (IC50 = 0.1 nM). LU103793 inhibits microtubule polymerization in a concentration-dependent manner (IC50 = 7 microM). Treatment with ... | |||
| T35875 | CCG258208 hydrochloride | ||
| GRKs-IN-1 hydrochloride, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=130 nM) and GRK5 (IC50=7.1 μM).GRKs-IN-1 hydrochloride is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine[1]. [1]. Waldschmidt HV, et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13;60(7):305... | |||
| T37114 | SB 242084 dihydrochloride | ||
| SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.IC50 value: 9.0(pKi) [1]Target: 5-HT2C antagonistin vitro: SB 242084 had over 100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors. In studies of 5-HT-stimulated phosphatidylinositol hydrolysis using SH-SY5Y cells stably expressing the cloned human 5-HT2C receptor, SB 242084 acted as an antagonist with a pKb of 9.... | |||
| Cat. No. | Product Name | Target | Signaling Pathways |
|---|---|---|---|
| T1400 |
Demeclocycline hydrochloride
Detravis,Clortetrin,地美环素,盐酸地美环素,Demeclocycline HCl,Declomycin |
Antibiotic; ribosome; Antibacterial | Microbiology/Virology |
| Demeclocycline hydrochloride 是四环素类抗生素，可治疗粉刺，莱姆病和支气管炎。 | |||
| T0486L |
Irinotecan Hydrochloride
盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride |
Topoisomerase; Autophagy | Autophagy; DNA Damage/DNA Repair |
| Irinotecan Hydrochloride 是喜树碱半合成衍生物的盐酸盐，是一种拓扑异构酶 I 抑制剂，可研究结肠癌和直肠癌。 | |||
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