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IL-4 Protein, Canine, Recombinant

产品编号 TMPY-02790

别名: 白介素, interleukin 4, 白细胞介素

IL-4 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13 kDa and the accession number is O77762.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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IL-4 Protein, Canine, Recombinant

规格	价格/CNY		货期	数量
20 μg	￥ 2,270		5日内发货
100 μg	￥ 4,420		5日内发货

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参考文献

生物活性	Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 5-30 ng/ml.
产品描述	IL-4 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13 kDa and the accession number is O77762.

种属	Canine
表达系统	E. coli
标签	Tag Free
蛋白编号	O77762
别名	白介素, interleukin 4, 白细胞介素
蛋白构建	The canine IL4 (O77762) (His 25-His 132) was expressed, with an initial Met at the N-terminus.
蛋白纯度	> 96 % as determined by SDS-PAGE
分子量	13 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin-4, also known as IL4, is a secreted protein that belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It enhances both secretion and cell surface expression of IgE and IgG1. Interleukin-4 / IL4 also regulates the expression of the low-affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Interleukin-4 is essential for the switching of B cells to IgE antibody production and the maturation of T helper (Th) cells toward the Th2 phenotype. It participates in at least several B-cell activation processes as well as other cell types. However, studies show that double mutant (Q116D, Y119D) of the murine IL4 protein (QY), both glutamine 116 and tyrosine 119, which binds to the IL4 receptor alpha, completely inhibits in a dose-dependent manner the IL4-induced proliferation of lipopolysaccharide-stimulated murine splenic B-cells, of the murine T cell line CTLL-2, and the murine pre-B-cell line BA/F3. QY also inhibited the IL4-stimulated up-regulation of CD23 expression by lipopolysaccharide-stimulated murine splenic B-cells and abolished tyrosine phosphorylation of the transcription factor Stat6 and the tyrosine kinase Jak3 in IL4-stimulated BA/F3 cells.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Grunewald SM. et al., 1998, J Immunol. 160 (8): 4004-9. 2. Susanne M. et al, 1997, THE JOURNAL OF BIOLOGICAL CHEMISTRY. 272 (3): 1480-3. 3. Nishikubo K. et al., 2003, Gene Ther. 10 (26): 2119-25.

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Keywords

IL-4 Protein, Canine, Recombinant 白介素 interleukin 4 白细胞介素 recombinant recombinant-proteins proteins protein

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