dsm 705

DSM705 is a pyrrole-based inhibitor of Dihydroorotate Dehydrogenase (DHODH). It demonstrates high potency in the nanomolar range against Plasmodium DHODH and Plasmodium parasites, while not interfering with mammalian DHODHs. DSM705 shows significant efficacy as an antimalarial compound.

DSM705 hydrochloride 是一种有效的抗疟化合物，是一种基于吡咯的二氢乳清酸脱氢酶 (DHODH) 抑制剂。DSM705 hydrochloride 对 PlasmodiumDHODH 和 Plasmodium 寄生虫显示出纳摩尔级作用，不抑制哺乳动物 DHODH。