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1,8-Diazafluoren-9-one

1,8-Diazafluoren-9-one

产品编号 T18971   CAS 54078-29-4
别名: 9H-1,8-Diazafluoren-9-one, 1,8-二氮杂-9-芴酮, DFO

DFO 是一种用于使在多孔表面上,能够发现指纹的化学物质。

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1,8-Diazafluoren-9-one, CAS 54078-29-4
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产品目录号及名称: 1,8-Diazafluoren-9-one (T18971)
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纯度: 99.91%
纯度: 99.91%
纯度: 98.81%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 DFO (9H-1,8-Diazafluoren-9-one) is used to find fingerprints on porous surfaces.
体外活性 1,8-diazafluoren-9-one (DFO) is used in the forensic field to enhance latent fingerprints deposited on porous surfaces due to the formation of fluorescent products by reacting with the amino acids present in the papillary exudate. DFO has been the most used because of its excellent enhancing properties.
别名 9H-1,8-Diazafluoren-9-one, 1,8-二氮杂-9-芴酮, DFO
分子量 182.18
分子式 C11H6N2O
CAS No. 54078-29-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

溶解度

DMSO: 20 mg/mL (109.78 mM), Need ultrasonic

( < 1 mg/mL refers to the product slightly soluble or insoluble )

参考文献

1. D'Elia V, et al. Evaluation and comparison of 1,2-indanedione and 1,8-diazafluoren-9-one solutions for the enhancement of latent fingerprints on porous surfaces. Forensic Sci Int. 2015 Sep;254:205-14. 2. Huang L, Liu Z, Liu H, et al. Iron Overload Impairs Bone Marrow Mesenchymal Stromal Cells from Higher-Risk MDS Patients by Regulating the ROS-Related Wnt/β-Catenin Pathway[J]. Stem cells international. 2020, 2020. 3. Huang S, Cao B, Zhang J, et al. Induction of ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B: molecular mechanism and therapeutic potential[J]. Cell Death & Disease . 2021, 12(3): 1-13. 4. Bebber C M, Thomas E S, Chen Z, et al. Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes[J]. Nature Communications. 2021

文献引用

1. Peng H, Zhang X, Yang P, et al. Defect self-assembly of metal-organic framework triggers ferroptosis to overcome resistance. Bioactive Materials. 2021 2. Bebber C M, Thomas E S, Chen Z, et al. Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nature Communications. 2021 Apr 6;12(1):2048. doi: 10.1038/s41467-021-22336-4. 3. Chen G, Fan X, Li Y, et al. Promoter aberrant methylation status of ADRA1A is associated with hepatocellular carcinoma. Epigenetics. 2020, 15(6-7): 684-701 4. Luo Y, Gao X, Zou L, et al. Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells. Oxidative Medicine and Cellular Longevity. 2021 5. Jiang H, Wang C, Zhang A, et al. ATF4 protects against sorafenib-induced cardiotoxicity by suppressing ferroptosis. Biomedicine & Pharmacotherapy. 2022, 153: 113280 6. Huang S, Cao B, Zhang J, et al. Induction of ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B: molecular mechanism and therapeutic potential. Cell Death & Disease. 2021, 12(3): 1-13. 7. Tan Q, Fang Y, Peng X, et al. A new ferroptosis inhibitor, isolated from Ajuga nipponensis, protects neuronal cells via activating NRF2-antioxidant response elements (AREs) pathway. Bioorganic Chemistry. 2021: 105177. 8. Peng X, Tan Q, Wu L, et al. Ferroptosis Inhibitory Aromatic Abietane Diterpenoids from Ajuga decumbens and Structural Revision of Two 3, 4-Epoxy Group-Containing Abietanes. Journal of Natural Products. 2022 9. Huang L, Liu Z, Liu H, et al Iron Overload Impairs Bone Marrow Mesenchymal Stromal Cells from Higher-Risk MDS Patients by Regulating the ROS-Related Wnt/β-Catenin Pathway. Stem Cells International. 2020 10. Jiang X, Teng X, Shi H, et al.Discovery and optimization of olanzapine derivatives as new ferroptosis inhibitors.Bioorganic Chemistry.2023: 106393.

相关化合物库

该产品包含在如下化合物库中:
共价抑制剂库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
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计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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X
X
X
=
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输入分子式,点击计算,可计算出产品的分子量。

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技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

1,8-Diazafluoren-9-one 54078-29-4 Others Inhibitor 9H-1,8-Diazafluoren-9-one inhibit 1,8 Diazafluoren 9 one 1,8-二氮杂-9-芴酮 1,8Diazafluoren9one DFO inhibitor

 

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