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DAPK

DAPK (Death-associated protein kinase) is the founding member of a newly classified family of Ser/Thr kinases, whose members not only possess significant homology in their catalytic domains, but also share cell death-associated functions. The realization that DAPk is a tumor suppressor gene, whose expression is lost in multiple tumor types, has spurred a flurry of interest in the kinase family and produced an impressive body of literature concerning its function, regulation, and connection to disease. The DAPk family has been linked to several cell death-related signaling pathways, and functions other than cell death have also been proposed.

Cat. No.	Product Name	CAS No.	Purity
T14779	BRD7389 化合物BRD7389	376382-11-5	98%
T14779	BRD7389 是一种 RSK 家族激酶抑制剂，对 RSK1、RSK2 和 RSK3 的 IC50 分别为 1.5 μM、2.4 μM 和 1.2 μM。
T17004	TC-DAPK 6 化合物TC-DAPK 6	315694-89-4	98%
T17004	TC-DAPK 6 是死亡相关蛋白激酶 (DAPK) 的 ATP 竞争性抑制剂，对 DAPK1 和 DAPK3 的 IC50 分别为 69 和 225 nM。
T27554	HS38 化合物HS38	1030203-81-6	98%
T27554	HS38 是一种特异性的 ATP 竞争性 DAPK 抑制剂，对 DAPK1、PIM3 和 ZIPK 的 Kds 分别为 300 nM、200 nM 和 280 nM。 HS38 可用于平滑肌相关疾病的研究。
TP2205L	DAPK Substrate Peptide acetate 化合物DAPK Substrate Peptide acetate		98%
TP2205L	DAPK Substrate Peptide acetate 是一种死亡相关蛋白激酶 (DAPK, Km = 9 μM) 肽底物。