Adenylyl cyclase

Adenylyl cyclase (also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells. It is the most polyphyletic known enzyme: six distinct classes have been described, all catalyzing the same reaction but representing unrelated gene families with no known sequence or structural homology. The best known class of adenylyl cyclases is class III or AC-III (Roman numerals are used for classes). AC-III occurs widely in eukaryotes and has important roles in many human tissues. All classes of adenylyl cyclase catalyse the conversion of adenosine triphosphate (ATP) to 3',5'-cyclic AMP (cAMP) and pyrophosphate. Magnesium ions are generally required and appear to be closely involved in the enzymatic mechanism. The cAMP produced by AC then serves as a regulatory signal via specific cAMP-binding proteins, either transcription factors, enzymes (e.g., cAMP-dependent kinases), or ion transporters.

Cat. No.	Product Name	CAS No.	Purity
T77502	Wnt pathway inhibitor 3 Wnt通路抑制剂3	663213-98-7	99.69%
T77502	Wnt pathway inhibitor 3 是一种有效的 AC1 抑制剂，IC50 值为 45 nM。Wnt pathway inhibitor 3 具有抗增殖活性，可用于研究改善实验性骨关节炎小鼠模型中的骨关节炎。
T2939	Forskolin 毛喉素	66575-29-9	98.83%
T2939	Forskolin (Coleonol) 属于天然产物，是一种腺苷酸环化酶激活剂 (EC50=0.5 μM)。Forskolin 可以增加 cAMP 水平，可以激活 PXR 和 FXR，也可以诱导细胞自噬。Forskolin 对心脏产生正性肌力作用，具有血小板抗凝集和降压作用。
T10066	2',5'-Dideoxyadenosine 化合物2',5'-Dideoxyadenosine	6698-26-6	98.66%
T10066	2',5'-Dideoxyadenosine 是一种非竞争性腺苷酸环化酶抑制剂，通过结合 P 位点，IC50为 3 µM。它是核苷类似物，在心脏中发挥强大的抗肾上腺素作用。
T16275	NB001 化合物NB001	686301-48-4	98.43%
T16275	NB001 (HTS 09836) 是腺苷酸环化酶 1 的抑制剂，对神经和非神经疼痛有作用。
T15787	LRE1 化合物LRE1	1252362-53-0	100%
T15787	LRE1是可溶性腺苷酸环化酶的特异性和变构抑制剂。
T16333	NKY80 化合物NKY80	299442-43-6	100%
T16333	NKY80 调节心脏和肺组织中的腺苷酸环化酶催化活性。 NKY80 是腺苷酸环化酶 V 型亚型的非竞争性抑制剂（IC50 值：V、III 和 II 型分别为 8.3 µM、132 µM 和 1.7 mM）。
T60003	AC1-IN-1 化合物 AC1-IN-1	2762422-55-7	100%
T60003	AC1-IN-1 是 1 型腺苷酸环化酶的选择性抑制剂（AC1，IC50 = 0.54 µM）。
T7813	α-MSH 美拉诺坦	581-05-5	100%
T7813	α-MSH (MSH, amide) 是一种内源性神经肽，是一种内源性黑皮质素受体 4 (MC4R) 激动剂，具有抗炎和解热活性。
T16938	ST034307 化合物ST034307	133406-29-8	98%
T16938	ST034307 是一种选择性 adenylyl cyclase 1抑制剂，IC50值为 2.3 μM。