suppressive

Wilforlide A (3-Epiabruslactone A) 是一种具有生物活性的三萜，从雷公藤中分离得到，具有抗炎和免疫抑制活性。

Peldesine (BCX 34) 是一种有效的、竞争性的、可逆的和口服活性的嘌呤核苷磷酸化酶抑制剂。 Peldesine 抑制 T 细胞增殖，IC50 为 800 nM。 Peldesine 可用于皮肤 T 细胞淋巴瘤、牛皮癣和 HIV 感染的研究。

Mizoribine (NSC-289637) 是一种免疫抑制剂，抑制HCVRNA 复制，有抗 HCV 活性，IC50约为 100 μM。它抑制SARS-CoV 复制，对 SARS-CoV Frankfurt-1 和 SARS-CoV HKU39849 的 IC50分别为 3.5 μg mL 和 16 μg mL。

Betamethasone (NSC-39470) 是一种合成糖皮质激素，具有免疫抑制和抗炎活性。它可加速胎儿肺成熟并诱导基因表达和细胞凋亡。

Sodium lauryl sulfoacetate (Sodium houttuyfonate) 是一种植物来源的固体阴离子表面活性剂，也是一种具有抗免疫抑制作用的免疫佐剂。

MP07-66 是 FTY720 的一种类似物，没有免疫抑制作用。MP07-66通过破坏 SET-PP2A 复合物导致PP2A 重新激活。MP07-66在慢性淋巴细胞白血病中显示出良好的抗肿瘤作用。

Trilostane (Win 24540) 是一种3 β-羟化类固醇脱氢酶抑制剂，能够作用于库兴氏综合征。

OTS514 (OTS514 Hydrochloride) 是一种高效的 TOPK 抑制剂，IC50为 2.6 nM。它强效抑制 TOPK 阳性的肿瘤细胞生长，还可诱导细胞周期停滞和凋亡。

αVβ8-IN-1 作为一种针对αVβ8整合素的抑制剂，展现了对诸如EMT6、CT26、KPC、TKCC-10等多种肿瘤细胞线的生长抑制作用。此化合物可应用于特发性肺纤维化 (IPF)、非特异性间质性肺炎 (NSIP) 和肿瘤相关的研究领域。

Betamethasone 17-Propionate 在实验中主要是探讨其对大鼠内毒素诱导的葡萄膜炎的治疗潜力。通过滴眼和全身给药的方式，该化合物能在一定剂量（全身给药时为 1 mg kg）下抑制细胞在房水中的渗入，尽管其效果相比其他化合物较弱。在体外实验中，Betamethasone 17-Propionate 对大鼠腹膜渗出细胞中的白细胞介素-8（IL-8）的抑制作用也不如倍他米松。研究还发现，当与倍他米松二丙酸酯共同使用时，两者的联合效应可能减弱对细胞浸润和IL-1β基因表达的抑制。

CP-31398 在具有p53突变或野生型的癌症细胞中通过稳定p53的活性构象，并且促进p53活性。它还能上调p53的目标基因，包括p21WAF1 Cip1和KILLER DR5，从而发挥抑制肿瘤生长的功能。

Cofpropamine 作为一种源自咖啡因的衍生物，能抑制多聚腺苷酸化。在大鼠的佐剂性关节炎和小鼠的胶原性关节炎模型中，它能增强Cyclophosphamide的抑制效果。

CG500354 plays a tumor suppressive role through the cAMP CREB signaling pathway and is a novel inducer of neural differentiation and growth arrest in primary HUMAN GBM derived cells.

β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities. It is produced via piomelanocortin cleavage in the pituitary gland, hypothalamus, and in lymphocytes, then migrates to its sites of action which include plasma, gut, skin, placenta, cerebrospinal fluid, and cardiac tissues. β-EP induces concentration-dependent decreases in electrically stimulated contraction of the mouse vas deferens that can be reversed by the μ-opioid antagonist CTP and δ-opioid antagonist ICI 174,864. In vivo, β-EP (5 μg, i.c.v.) slows gastrointestinal transit in mice. β-EP (0.5 or 5 μg, i.c.v.) stimulates food intake in rats for 4 to 6 hours, however, this effect is not prolonged with continuous infusion. It antagonizes the appetite-suppressive effects of α-melanocyte-stimulating hormone (α-MSH) for the first three days post administration. β-EP also reduces paralytic demyelination induced by the murine coronavirus MHV-JHM in immunocompetent, but not irradiated or immune-incompetent, mice and rats.

Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities.1,2,3 It inhibits secretion of hepatitis B virus surface antigen (HBsAg) by Hep3B cells expressing hepatitis B virus (HBV) DNA (IC50 = 1.3 μM).1 Destruxin B2 is toxic to Sf9 insect cells in an electric cell-substrate impedance sensing (ECIS) test with a 50% inhibitory concentration (ECIS50) value of 92 μM.4 It is also phytotoxic to B. napus leaves.3 |1. Yeh, S.F., Pan, W., Ong, G.-T., et al. Study of structure-activity correlation in destruxins, a class of cyclodepsipeptides possessing suppressive effect on the generation of hepatitis B virus surface antigen in human hepatoma cells. Biochem. Biophys. Res. Commun. 229(1), 65-72 (1996).|2. Male, K.B., Tzeng, Y.-M., Montes, J., et al. Probing inhibitory effects of destruxins from Metarhizium anisopliae using insect cell based impedance spectroscopy: Inhibition vs chemical structure. Analyst 134(7), 1447-1452 (2009).|3. Buchwaldt, L., and Green, H. Phytotoxicity of destruxin B and its possible role in the pathogenesis of Alternaria brassicae. Plant Pathol. 41(1), 55-63 (1992).

TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2]. TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3[1]. TEI-9648 has consistently weaker suppressive effect than TEI-9647[1]. TEI-9648 can not induce cell differentiation even after treatment at 1 μM in HL-60 cell[1]. TEI-9648 alone can not induce activation of NBT-reducing activity or α-NB esterase activity. In contrast, TEI-9648 markedly suppresses the up-regulation induced by 1α,25(OH)2D3 (0.1 nM) in HL-60 cells[1]. [1]. Miura D, et al. Antagonistic action of novel 1α,25-dihydroxyvitamin D3-26, 23-lactone analogs on differentiation of human leukemia cells (HL-60) induced by 1α,25-dihydroxyvitamin D3. J Biol Chem. 1999 Jun 4;274(23):16392-9. [2]. Kazuya Takenouchi, et al. Synthesis and structure-activity relationships of TEI-9647 derivatives as Vitamin D3 antagonists. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):31-4.

4-Maleimidosalicylic acid is a polar maleimide compound that does not exhibit suppressive effects on IL-2 production in JURKAT T cells.

D-(+)-Sorbose，一种 D-Sorbose 的活性对映异构体，可抑制双糖酶活性并对大鼠餐后血糖和胰岛素水平有抑制作用。D-Sorbose 作为甜味剂有助于预防相关疾病，如 2 型糖尿病。

FLDP-5 为一种可透过血脑屏障的姜黄素类似物，能够诱导活性氧（ROS）产生、DNA损伤及细胞周期S期阻滞。此外，FLDP-5 在抑制LN-18细胞增殖和迁移方面表现出显著的抗肿瘤活性。

(Rac)-Mono(3,5,5-trimethylhexyl) phthalate 为常见邻苯二甲酸酯增塑剂的关键代谢物，具备免疫抑制功能。

Tregalizumab为人源化抗CD4单克隆抗体（IgG1型），体外能选择性激活调节性T细胞（Tregs）功能。适用于研究自身免疫性疾病（因Treg功能不足）及过敏反应。

Topsalysin为PSA激活的前体蛋白质，同时是与人前列腺特异性抗原融合的孔隙形成蛋白（合成原气溶素）。研究显示Topsalysin能够抑制小鼠模型中的肿瘤生长。

Pancreastatin (33-49), porcine，一种来自猪胰腺的肽片段，体外显示出抑制胰岛素的活性，并增强葡萄糖启动作用。

Laxiflorin B-4为改性Laxiflorin B，其对ERK1 2的亲和力更高，具备更强的抗肿瘤活性。