snap

NO donor

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) 是一种稳定的血小板聚集抑制剂，是一氧化氮的供体。

SNAP 398299 是一种甘丙肽受体 3 型 （Gal3）拮抗剂，具有抗焦虑和抗抑郁样作用，可用于研究情绪障碍。

(S)-SNAP5114 是一种选择性的 GABA 转运抑制剂，对 hGAT-3 的 IC50 为 5 μM，对 rGAT-2 的 IC50 为 21 μM。 (S)-SNAP5114 具有抗惊厥性质。

SNAP 94847 hydrochloride 是一种选择性黑色素浓缩激素受体1 拮抗剂，Ki 为 2.2 nM，具有抗抑郁样活性。它是 MCH 诱发的肌醇磷酸形成的高亲和力拮抗剂 ，pA2为 7.81。

SNAP-7941 is a selective antagonist of the melanin concentrating hormone receptor MCH1 with promising anxiolytic, antidepressant and anorectic effects in initial animal studies.

SNAP-8719 is a selective antagonist of α1D-AR. SNAP-8719 showed better selectivity for α1D-AR and lower binding affinity for the 5-HT1A receptor.

SNAP8 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-Nh2) 是 SNAP-25 N 末端的模拟物，它与 SNAP-25 竞争 SNARE 复合物中的位置，从而调节其形成。

SNAP8 Acetate(868844-74-0,free base) 减少皱纹出现。

SNAP-5089 is a highly selective alpha1A-adrenoceptor antagonist.

Alkyne-PEG5-SNAP 是一种点击化学试剂,具备炔基团.该化合物能与苄基鸟嘌呤(BG)发生炔基共轭反应.BG能与SNAP-标签(一种多肽蛋白标记技术)特异性地快速反应,赋予SNAP融合蛋白以不可逆和共价的性质,并提供额外的炔基功能以便进一步的偶联反应.此外,Alkyne-PEG5-SNAP 可通过与含Azide基团的分子进行铜催化的叠氮-炔环加成反应(CuAAc) 进行反应.

Alkyne-SNAP (compound 3) 为一炔烃偶联型苄基鸟嘌呤.其苄基鸟嘌呤结构能与SNAP-标签进行反应,用于对SNAP融合蛋白进行不可逆共价标记,而炔烃部分则可用于后续的点击化学反应.

This amino acids187 to 203 fragment is derived from the C-terminal helix of synaptosomal-associated protein of 25 kDa (SNAP-25). This peptide is able to rescue exocytosis from botulinum neurotoxin E (BoNT E)-treated cells, albeit at higher concentrations

α1A-adrenoceptor antagonist

SNAP 94847 (SNAP-94847) 是一种选择性黑色素浓缩激素受体1 拮抗剂，Ki 为 2.2 nM。它具有抗焦虑和抗抑郁活性，可减少小鼠的食物摄入。

L-771688（SNAP 6383） 是一种新型有效和选择性的 α1A-肾上腺素受体拮抗剂， Ki 值为 0.43±0.02 nM。L-771688 KE 用于治疗良性前列腺增生。

HT-2157 (SNAP-37889) 是一种高亲和力、选择性和竞争性的甘丙肽 3 受体 (Gal3) 拮抗剂。

N-Acetyl-DL-penicillamine is a chelating agent.1,2,3It inhibits the binding of methyl mercury to isolated human erythrocytes by 50% and removes 50% of methyl mercury ions from methyl mercury-loaded blood cells when used at a concentration of 1 mM.1,2N-Acetyl-DL-penicillamine (3 mmol kg per day, p.o.) reduces the biological half-life of mercury and decreases liver, kidney, brain, and blood mercury levels, as well as increases urinary excretion of mercury in a concentration-dependent manner, in mice when administered following injection of methyl mercuric chloride. It decreases mercuric chloride-induced mortality in mice when administered orally at a dose of 1.6 mmol kg.3N-Acetyl-DL-penicillamine is also an analog of SNAP that does not generate nitric oxide and has been used as a negative control in experiments using SNAP.4,5

BGN3 is a good substrate for the SNAP- tag and H 5 enzymes. The activities of SNAP- tag and H 5 enzymes on BGN3 are reasonable (IC 50 = 15.6 and 23.5 μM, respectively).

HaXS8 is a dimerizer that facilitates the covalent and irreversible intracellular dimerization of proteins of interest labeled with HaloTag and SNAP-tag. Furthermore, HaXS8 does not exhibit any interference with PI3K mTOR signaling.

T4 UvsX Recombinase 促进双链DNA模板上DNA复制的启动，通过催化模板DNA与同源单链DNA引物间的突触形成。此酶显著增强了T4 DNA聚合酶全酶在线性单链DNA模板上进行的回跳（发夹引物）DNA合成反应。

Dienochlor (Decachlor) 作为一种杀螨剂,可有效阻止墨西哥豆甲虫 (Epilachna varivestis Mulsant) 在花豆上的产卵行为.

Entagenic acid，一种从菜豆种子提取的糖苷配体，常应用于抗糖尿病研究。